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Comparative Study of Antibiofilm Activity of Copper Oxide and Iron Oxide Nanoparticles Against Multidrug Resistant Biofilm Forming Uropathogens

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Abstract

The effectiveness of the metal oxide nanoparticles viz. CuO and Fe2O3 as antibacterial agents against multidrug resistant biofilm forming bacteria was evaluated. CuO nanoparticles were also experimented for antibiofilm and time kill assay. The CuO displayed maximum antibacterial activity with zone of inhibition of (22 ± 1) mm against methicillin resistant Staphylococcus aureus (MRSA) followed by Escherichia coli (18 ± 1) mm. The Fe2O3 showed the zone of inhibition against MRSA of (14 ± 1) mm followed by E. coli (12 ± 1) mm. CuO proved to be more toxic than Fe2O3 nanoparticles showing significantly high antibacterial activity and found to possess dose dependent antibiofilm properties.

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Acknowledgments

M. Agarwala thanks Rup Agarwala Foundation for financial support. Financial support from DBT, India is gratefully acknowledged. Authors also thank IASST, Guwahati for XRD and SEM analyses.

Ethical Standards

The present study was approved by the Ethics Committee of Dibrugarh University, Assam, India.

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Authors and Affiliations

  1. Centre for Studies in Biotechnology, Dibrugarh University, Dibrugarh, 786004, Assam, India

    Munin Agarwala & R. N. S. Yadav

  2. Guwahati Biotech Park, Technology Complex, IIT-Guwahati, Guwahati, 781039, Assam, India

    Bula Choudhury

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  1. Munin Agarwala
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  2. Bula Choudhury
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  3. R. N. S. Yadav
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Correspondence to Bula Choudhury.

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Agarwala, M., Choudhury, B. & Yadav, R.N.S. Comparative Study of Antibiofilm Activity of Copper Oxide and Iron Oxide Nanoparticles Against Multidrug Resistant Biofilm Forming Uropathogens. Indian J Microbiol 54, 365–368 (2014). https://doi.org/10.1007/s12088-014-0462-z

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  • DOI: https://doi.org/10.1007/s12088-014-0462-z

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