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Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies

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  • Molecular Targets in Oncology
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Abstract

Chemotherapy-induced peripheral neuropathy (CIN) is a common toxicity of anticancer treatment and its incidence is growing. It significantly affects quality of life and is a dose-limiting factor that interferes with treatment. Its diagnosis can be established in clinical terms but some complementary tests can help when the diagnosis is difficult. There is still no proven method to prevent it that has become a standard of care in spite of the huge amount of investigation carried out in recent years. There are promising strategies that could help reduce the burden of this complication. This review will suggest an approach to the diagnosis of these disorders and provide an update on new therapies.

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Authors and Affiliations

  1. Neurology Department, Infanta Sofía Hospital, San Sebastián de los Reyes, Madrid, Spain

    Gerardo Gutiérrez-Gutiérrez & Ambrosio Miralles

  2. Medical Oncology Department, Infanta Sofía Hospital, Paseo de Europa, 34, ES-28702, San Sebastián de los Reyes, Madrid, Spain

    María Sereno & Enrique Casado-Sáenz

  3. Neuromuscular Unit Neurology Department, Hospital Universitario 12 de Octubre, Madrid, Spain

    Eduardo Gutiérrez-Rivas

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  1. Gerardo Gutiérrez-Gutiérrez
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  2. María Sereno
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  3. Ambrosio Miralles
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  4. Enrique Casado-Sáenz
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  5. Eduardo Gutiérrez-Rivas
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Correspondence to María Sereno.

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Gutiérrez-Gutiérrez, G., Sereno, M., Miralles, A. et al. Chemotherapy-induced peripheral neuropathy: clinical features, diagnosis, prevention and treatment strategies. Clin Transl Oncol 12, 81–91 (2010). https://doi.org/10.1007/S12094-010-0474-z

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