Skip to main content

Advertisement

SpringerLink
Log in

Neuroblastoma: A Review of Management and Outcome

  • Symposium on Pediatric Oncology : Malignant Solid Tumors
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Solid tumors in children are a major cause of death in the developed countries and now even in the developing countries. Of these tumors, neuroblastoma, the most common tumor in children, despite extensive and on-going research and clinical trials still remains an enigma. About 50 % of children with neuroblastoma overall succumb to the disease. This tumor generates lot of curiosity in developing newer therapies for management, but creates equal amount of frustration albeit a risk-stratification system, patients with the same clinical-pathologic parameters and being treated with the same protocols may have markedly different clinical courses and outcomes. Most of the neuroblastomas are sporadic but some are familial. This article aims at understanding the different protocols existing for the risk stratification and management of neuroblastomas. Further, it also aims to study the outcomes of the several different stages of the tumor all across the country as well as in India.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chu CM, Rasalkar DD, Hu YJ, Cheng FWT, Li CK, Chu WCW. Clinical presentations and imaging findings of neuroblastoma beyond abdominal mass and a review of imaging algorithm. Br J Radiol. 2011;84:81–91.

    Article  PubMed  CAS  Google Scholar 

  2. Laverdière C, Liu Q, Yasui Y, et al. Long-term outcomes in survivors of neuroblastoma: a report from the childhood cancer survivor study. J Natl Cancer Inst. 2009;101:1131–40.

    Article  PubMed  Google Scholar 

  3. en.wikipedia.org/wiki/Neuroblastoma. Accessed on 12/1/12.

  4. Beckwith B, Perrin EV. In situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol. 1963;43:1089–104.

    PubMed  CAS  Google Scholar 

  5. Pritchard J, Cotterill SJ, Germond SM, Imeson J, de Kraker J, Jones DR. High dose melphalan in the treatment of advanced neuroblastoma: results of a randomized trial (ENSG-1) by the European Neuroblastoma Study Group. Pediatr Blood Cancer. 2005;44:348–57.

    Article  PubMed  Google Scholar 

  6. Pearson AD, Pinkerton CR, Lewis IJ, et al. High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomized trial. Lancet Oncol. 2008;9:247–56.

    Article  PubMed  CAS  Google Scholar 

  7. Matthay KK, Villablanca JG, Seeger RC, et al. Treatment of high risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation and 13-cis-retinoic acid. Children’s Cancer Group. N Engl J Med. 1999;341:1165–73.

    Article  PubMed  CAS  Google Scholar 

  8. Berthold F, Boos J, Burdach S, et al. Myeloablative megatherapy with autologous stem cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high risk neuroblastoma: a randomized controlled trial. Lancet Oncol. 2005;6:649–58.

    Article  PubMed  CAS  Google Scholar 

  9. Clinical Trials PDQ- National Cancer Institute. Retrieved 2011-27-12.

  10. Observation, combination chemotherapy, radiation therapy, and/or autologous stem cell transplant in treating young patients with neuroblastoma – Full text view-Clinical Trials gov.

  11. George RE, Li S, Medeiros-Nancarrow C, et al. High risk neuroblastoma treated with tandem autologous peripheral blood stem cell-supported transplantation:long term-survival update. J Clin Oncol. 2006;24:2891–6.

    Article  PubMed  Google Scholar 

  12. Cohn SL, Pearson ADJ, London WB, et al. The international neuroblastoma risk group (INRG) classification system: an INRG task force report. J Clin Oncol. 2009;27:289–97.

    Article  PubMed  Google Scholar 

  13. Cohn SL, London WB, Monclair T, Matthay KK, Ambros PF, Pearson AD, for the INRG Working Group. Update on the development of the international neuroblastoma risk group (INRG) classification schema. J Clin Oncol. 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition).2007;25:9503.

  14. Monclair T. The new international neuroblastoma risk group staging system-implications for surgeons. SIOP Education Book 2920, pp. 64–6.

  15. Bosworth T. New neuroblastoma classification could facilitate trials. Clinical Oncology News Solid Tumors. 2007;02:09.

    Google Scholar 

  16. www.cncfhope.org/High_Risk_Neuroblastoma_Treatment. Accessed on 02/1/12

  17. Defachelles AS, Cougnenc O, Carpentier P. Radio iodised metaiodobenzylguanidine (MIBG) in the treatment of neuroblastoma: modalities and indications. Bull Cancer. 2011;98:559–69.

    PubMed  Google Scholar 

  18. Park JR, Eggert A, Caron H. Neuroblastoma: biology, prognosis and treatment. Pediatr Clin North Am. 2008;55:97–120.

    Article  PubMed  Google Scholar 

  19. Modak S, Cheung NK. Neuroblastoma: therapeutic strategies for a clinical enigma. Cancer Treat Rev. 2010;36:307–17.

    Article  PubMed  CAS  Google Scholar 

  20. Kushner BH, Cohn SL, Matthay KK, et al. Risk status and surgical intervention. In: Cheung I, Cohn SL, eds. Neuroblastoma. Heidelberg: Springer; 2005. pp. 155.

    Google Scholar 

  21. Kaneko M. Past and future role of surgery in neuroblastoma. Nihon Geka Gakkai Zasshi. 2005;106:418–21.

    PubMed  Google Scholar 

  22. Salim A, Mullassery D, Pizer B, McDowell HP, Losty PD. Neuroblastoma: a 20-year experience in a UK regional centre. Pediatr Blood Cancer. 2011;57:1254–60.

    Article  PubMed  Google Scholar 

  23. Holgerson LO, Subramaniam S, Kirpekar M, Mootabar H, Marcus JR. Spontaneous resolution of antenatally diagnosed adrenal masses. J Pediatr Surg. 1996;31:153–5.

    Article  Google Scholar 

  24. Grandó A, Monteggía V, Gandar C, Ruano R, Bunduki V, Zugaib M. Prenatal sonographic diagnosis of adrenal neuroblastoma. J Clin Ultrasound. 2001;29:250–3.

    Article  PubMed  Google Scholar 

  25. Kostyrka B, Li J, Soundappan SV, et al. Features and outcomes of neonatal neuroblastoma. Pediatr Surg Int. 2011;27:937–41.

    Article  PubMed  CAS  Google Scholar 

  26. Granata C, Fagnani AM, Gambini C, et al. Features and outcome of neuroblastoma detected before birth. J Pediatr Surg. 2000;35:88–91.

    Article  PubMed  CAS  Google Scholar 

  27. Michalowski MB, Rubie H, Michon J, et al. Neonatal localized neuroblastoma: 52 cases treated from 1990 to 1999. Arch Pediatr. 2004;11:782–8.

    Article  PubMed  CAS  Google Scholar 

  28. Acharya S, Jayabose S, Kogan SJ, et al. Prenatally diagnosed neuroblastoma. Cancer. 1997;80:304–10.

    Article  PubMed  CAS  Google Scholar 

  29. Jennings RW, LaQuaglia MP, Leong K, Hendren WH, Adzick NS. Fetal neuroblastoma: prenatal diagnosis and natural history. J Pediatr Surg. 1993;28:1168–74.

    Article  PubMed  CAS  Google Scholar 

  30. Ho PT, Estroff JA, Kozakewich H, et al. Prenatal detection of neuroblastoma: a ten-year experience from the Dana-Farber Cancer Institute and Children's Hospital. Pediatrics. 1993;92:358–64.

    PubMed  CAS  Google Scholar 

  31. Auber F, Larroquet M, Bonnard A, et al. Prenatal ultrasound diagnosis of neuroblastoma. Gynecol Obstet Fertil. 2005;33:228–31.

    Article  PubMed  CAS  Google Scholar 

  32. Moon SB, Shin HB, Seo JM, Lee SK. Clinical features and surgical outcome of a suprarenal mass detected before birth. Pediatr Surg Int. 2010;26:241–6.

    Article  PubMed  Google Scholar 

  33. Davidoff AM. Neuroblastoma. Semin Pediatr Surg. 2012;21:2–14.

    Article  PubMed  Google Scholar 

  34. Verissimo CS, Molenaar JJ, Fitzsimons CP, Vreugdenhil E. Neuroblastoma therapy: what is in the pipeline? Endocr Relat Cancer. 2011;18:R213–31.

    Article  PubMed  CAS  Google Scholar 

  35. El-Sayed MI, Ali AM, Sayed HA, Zaky EM. Treatment results and prognostic factors of pediatric neuroblastoma: a retrospective study. Int Arch Med. 2010;3:37.

    Article  PubMed  Google Scholar 

  36. Dong K-R, Li K, Gao J-C, Lu Z-B, Xiao X-M. Treatment results of neuroblastoma with a standardization protocol. Chinese J Pediatr Surg. 2008;29.

  37. Matthay KK, Perez C, Seeger RC, et al. Successful treatment of stage III neuroblastoma based on prospective biologic staging: a Children's Cancer Group study. J Clin Oncol. 1998;16:1256–64.

    PubMed  CAS  Google Scholar 

  38. Balwierz W, Wieczorek A, Klekawka T, et al. Treatment results of children with neuroblastoma: report of Polish Pediatric Solid Tumor Group. Przegl Lek. 2010;67:387–92.

    PubMed  Google Scholar 

  39. Bansal D, Marwaha RK, Trehan A, Rao KL, Gupta V. Profile and outcome of neuroblastoma with conventional chemotherapy in children older than one year: a 15-years experience. Indian Pediatr. 2008;45:135–9.

    PubMed  Google Scholar 

  40. Kusumakumary P, Ajithkumar TV, Ratheesan K, Chellam VG, Nair MK. Pattern and outcome of neuroblastoma. A 10 year study. Indian Pediatr. 1998;35:223–9.

    PubMed  CAS  Google Scholar 

  41. Rao SR, Iyer RS, Nair CN, Kurkure PA, Pai SK, Advani SH. Infantile neuroblastoma: 10 year TMH experience. Indian J Cancer. 1993;30:85–7.

    PubMed  CAS  Google Scholar 

Download references

Conflict of Interest

None.

Role of Funding Source

None.

Author information

Authors and Affiliations

  1. Department of Pediatric Surgery, B.J. Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai, Maharashtra, 400 012, India

    Sushmita Nitin Bhatnagar

  2. Department of Pediatric Surgery, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, India

    Yogesh Kumar Sarin

Authors
  1. Sushmita Nitin Bhatnagar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yogesh Kumar Sarin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sushmita Nitin Bhatnagar.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhatnagar, S.N., Sarin, Y.K. Neuroblastoma: A Review of Management and Outcome. Indian J Pediatr 79, 787–792 (2012). https://doi.org/10.1007/s12098-012-0748-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12098-012-0748-2

Keywords

Search

Navigation