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90Y bremsstrahlung emission computed tomography using gamma cameras

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Abstract

Objective

This study demonstrates images obtained by 90Y bremsstrahlung emission computed tomography (BECT), and characterizes the system performance of gamma cameras.

Methods

90Y BECT images of phantoms were acquired using a gamma camera equipped with a medium energy general purpose parallel-hole collimator. Three energy window widths of 50% (57–94 keV) centered at 75 keV, 30% (102–138 keV) at 120 keV, and 50% (139–232 keV) at 185 keV were set on a 90Y bremsstrahlung spectrum. The images obtained with three energy windows were reconstructed using filtered back projection (FBP) and ordered subsets expectation maximization (OSEM) methods. The images of the sum window were obtained by fusing the images of the 75, 120, and 185 keV windows.

Results

The OSEM method improved the full width at half maximum by 20% and the standard deviation by 9% compared with the FBP method. BECT displayed 90Y biodistribution and quantified 90Y activity. BECT images obtained with OSEM method using the 120 keV window showed the highest resolution and lowest uncertainty. The sum window showed the highest sensitivity, while its resolution was 10% inferior to that of the 120 keV window. One whole-body image can be taken over 100 min using the sum window. An absorber to cover the body surface reduced background by 30%.

Conclusions

90Y BECT imaging can be used for patient assessment without modifying current treatment procedures.

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Authors and Affiliations

  1. Radioisotope Research Center, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8602, Japan

    Shigeki Ito & Kunihide Nishizawa

  2. Research Department, Fuji Film RI Pharma Co. Ltd, Sammu, Chiba, Japan

    Hiroyuki Kurosawa, Hiroyuki Kasahara, Satomi Teraoka & Takao Minamizawa

  3. Diagnostic Imaging Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan

    Eiji Ariga

  4. Department of Radiological Technology, Kobe Co-Medical College, Kobe, Japan

    Shizuhiko Deji

  5. Department of Nuclear Engineering and Management, The University of Tokyo, Tokyo, Japan

    Masahiro Hirota

  6. Radioisotope Research Center, Tokushima University, Tokushima, Japan

    Takuya Saze

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  1. Shigeki Ito
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  2. Hiroyuki Kurosawa
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  3. Hiroyuki Kasahara
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  4. Satomi Teraoka
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Correspondence to Shigeki Ito.

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Ito, S., Kurosawa, H., Kasahara, H. et al. 90Y bremsstrahlung emission computed tomography using gamma cameras. Ann Nucl Med 23, 257–267 (2009). https://doi.org/10.1007/s12149-009-0233-9

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  • DOI: https://doi.org/10.1007/s12149-009-0233-9

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