Skip to main content
Log in

Cognitive, Neurobiological and Psychopathological Alterations Associated with Child Maltreatment: A Review of Systematic Reviews

  • Published:
Child Indicators Research Aims and scope Submit manuscript

Abstract

The impact of childhood maltreatment has been studied in the last decades in several countries. This study aims to provide a review of systematic reviews about the relationship between neurobiological and cognitive impairments, psychiatric disorders and child maltreatment. PsycInfo, Pubmed and Scielo databases were searched to include reviews published from 2004 to 2014. Fifteen reviews about the impact of child maltreatment were analysed. Four of them deal with the neurobiological effects, two with the cognitive damages, and nine of them with the development of psychiatric disorders throughout the victim’s lifetime. The association between childhood maltreatment and the development of psychiatric disorders is the one that has received the most attention in the last few decades. The impact of maltreatment in cognition, above all in childhood, has been the least studied area; few studies, presenting conflicting results, were found.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Butchart, A., Harvey, P. H., Mian, M., Furniss, T., & Jahane, T. (2006). Preventing Child Maltreatment: a guide to taking action and generating evidence (p. 102). World Health Organization.

  • Dannlowski, U., Kugel, H., Huber, F., Stuhrmann, A., Redlich, R., Grotegerd, D., … Suslow, T. (2013). Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala. Human brain mapping, 34(11), 2899–909. doi:10.1002/hbm.22112

  • Diamond, A. (2012). Activities and programs that improve children’s executive functions. Current Directions in Psychological Science, 21(5), 335–341.

    Article  Google Scholar 

  • Diseth, T. H. (2005). Dissociation in children and adolescents as reaction to trauma–an overview of conceptual issues and neurobiological factors. Nordic journal of psychiatry, 59(2), 79–91. doi:10.1080/08039480510022963.

    Article  Google Scholar 

  • Fry, D., McCoy, A., & Swales, D. (2012). The consequences of maltreatment on children’s lives: a systematic review of data from the East Asia and Pacific Region. Trauma, Violence & Abuse, 1–25. doi:1524838012455873.

  • Gelles, R. J., & Perlman, S. (2012). Healthy families mean healthy children. Healthy communities. A thriving economy and strong nation. Investments in prevention support healthy child development and lower the number of children affected by abuse and neglect, and the financial cost to our na. Child Abuse and Neglect.

  • Habigzang, L. F., Koller, S. H., Azevedo, G. A., & Machado, P. X. (2005). Abuso sexual infantil e dinâmica familiar: aspectos observados em processos jurídicos. Psicologia: teoria e pesquisa, 21(3), 341–348.

    Google Scholar 

  • Hart, H., & Rubia, K. (2012). Neuroimaging of child abuse: a critical review. Frontiers in human neuroscience, 6.

  • Hayes, J. P., LaBar, K. S., McCarthy, G., Selgrade, E., Nasser, J., Dolcos, F., & Morey, R. A. (2011). Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD. Journal of psychiatric research, 45(5), 660–669. doi:10.1016/j.jpsychires.2010.10.007.

    Article  Google Scholar 

  • Hillberg, T., Hamilton-Giachritsis, C., & Dixon, L. (2011). Review of meta-analyses on the association between child sexual abuse and adult mental health difficulties: a systematic approach. Trauma, violence & abuse, 12(1), 38–49. doi:10.1177/1524838010386812.

    Article  Google Scholar 

  • Huang, L.-T. (2014). Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms. Frontiers in molecular neuroscience, 7, 1–38. doi:10.3389/fnmol.2014.00008.

    Article  Google Scholar 

  • Irigaray, T. Q., Fonseca, R. P., Pacheco, J., Leite, José Carlos de Carvalho, Grassi-Oliveira, R., & Kristensen, C. H. (2013). Child Maltreatment and Later Cognitive Functioning: A Systematic Review. Psicologia: Reflexão e Crítica, 26(2), 376–387.

  • Krug, E. G., Dahlberg, L. L., Mercy, J. A., Zwi, A. B., & Lozano, R. (2002). World report on violence and health. World Health Organization (p. 360). Geneva: World Health Organization.

  • Lebel, C., & Beaulieu, C. (2011). Longitudinal development of human brain wiring continues from childhood into adulthood. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10937–10947. doi:10.1523/JNEUROSCI.5302-10.2011.

    Article  Google Scholar 

  • Lenroot, R. K., & Giedd, J. N. (2006). Brain development in children and adolescents: insights from anatomical magnetic resonance imaging. Neuroscience and biobehavioral reviews, 30(6), 718–729. doi:10.1016/j.neubiorev.2006.06.001.

    Article  Google Scholar 

  • MacQueen, G., & Frodl, T. (2011). The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? Molecular psychiatry, 16(3), 252–264. doi:10.1038/mp.2010.80.

    Article  Google Scholar 

  • Maniglio, R. (2010). Child sexual abuse in the etiology of depression: A systematic review of reviews. Depression and anxiety, 27(7), 631–642. doi:10.1002/da.20687.

    Article  Google Scholar 

  • Maniglio, R. (2011). The role of child sexual abuse in the etiology of substance-related disorders. Journal of addictive diseases, 30(3), 216–228. doi:10.1080/10550887.2011.581987.

    Article  Google Scholar 

  • Maniglio, R. (2013a). Child sexual abuse in the etiology of anxiety disorders: a systematic review of reviews. Trauma, violence & abuse, 14(2), 96–112. doi:10.1177/1524838012470032.

  • Maniglio, R. (2013b). Prevalence of child sexual abuse among adults and youths with bipolar disorder: a systematic review. Clinical psychology review, 33(4), 561–573. doi:10.1016/j.cpr.2013.03.002.

    Article  Google Scholar 

  • Martins, C. M. S., Tofoli, S. M. D. C., Baes, C. V. W., & Juruena, M. (2011). Analysis of the occurrence of early life stress in adult psychiatric patients: a systematic review. Psychology & Neuroscience, 4(2), 219–227. doi:10.3922/j.psns.2011.2.007.

    Article  Google Scholar 

  • Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012). The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS medicine, 9(11). doi:10.1371/journal.pmed.1001349

  • Organization, W. H. (2014). Child maltreatment. Retrieved April 01, 2014, from http://www.who.int/mediacentre/factsheets/fs150/en/

  • Parks, R. W., Stevens, R. J., & Spence, S. A. (2007). A systematic review of cognition in homeless children and adolescents. Journal of the Royal Society of Medicine, 100(1), 46–50. doi:10.1258/jrsm.100.1.46.

    Article  Google Scholar 

  • Pechtel, P., & Pizzagalli, D. A. (2011). Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology, 214(1), 55–70. doi:10.1007/s00213-010-2009-2.

    Article  Google Scholar 

  • Pereda, N., & Gallardo-Pujol, D. (2011). Neurobiological consequences of child sexual abuse: a systematic review. Gaceta sanitaria / S.E.S.P.A.S, 25(3), 233–239. doi:10.1016/j.gaceta.2010.12.004.

    Article  Google Scholar 

  • Von Werne Baes, C., de Carvalho Tofoli, S. M., Martins, C. M. S., & Juruena, M. F. (2012). Assessment of the hypothalamic-pituitary-adrenal axis activity: glucocorticoid receptor and mineralocorticoid receptor function in depression with early life stress - a systematic review. Acta Neuropsychiatrica, 24(1), 4–15. doi:10.1111/j.1601-5215.2011.00610.x.

    Article  Google Scholar 

  • Woon, F. L., & Hedges, D. W. (2008). Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis. Hippocampus, 18(8), 729–736. doi:10.1002/hipo.20437.

    Article  Google Scholar 

  • Yehuda, R., Halligan, S. L., & Grossman, R. (2001). Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Development and psychopathology, 13(3), 733–753. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/11523857.

    Article  Google Scholar 

Download references

Acknowledgments

This research was supported in part by grants from the National Center of Scientific and Technology Development (CNPq, Brazil).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Janaína C. N. Carvalho.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carvalho, J.C.N., Donat, J.C., Brunnet, A.E. et al. Cognitive, Neurobiological and Psychopathological Alterations Associated with Child Maltreatment: A Review of Systematic Reviews. Child Ind Res 9, 389–406 (2016). https://doi.org/10.1007/s12187-015-9314-6

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12187-015-9314-6

Keywords

Navigation