References
Schmidt S, Debant A (2014) Function and regulation of the Rho guanine nucleotide exchange factor Trio. Small GTPases 5:e29769
Lane J, Martin TA, Mansel RE, Jiang WG (2008) The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. Int Semin Surg Oncol 5:23
Molenaar JJ, Koster J, Zwijnenburg DA, van Sluis P, Valentijn LJ, van der Ploeg I, Hamdi M, van Nes J, Westerman BA, van Arkel J, Ebus ME, Haneveld F, Lakeman A, Schild L, Molenaar P, Stroeken P, van Noesel MM, Ora I, Santo EE, Caron HN, Westerhout EM, Versteeg R (2012) Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 483:589–593
Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L (2012) A landscape of driver mutations in melanoma. Cell 150:251–263
Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29:673–680
Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12:323–334
Jo YS, Choi MR, Song SY, Kim MS, Yoo NJ, Lee SH (2016) Frameshift mutations of HSPA4 and MED13 in gastric and colorectal cancers. Pathol Oncol Res 22:769–772
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This study was supported by a grant from Korea Research Foundation (2012R1A5A2047939).
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Eun Ji Choi and Min Sung Kim contributed equally to this work.
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Choi, E.J., Kim, M.S., Yoo, N.J. et al. TRIO Gene Encoding Trio Rho Guanine Nucleotide Exchange Factor Harbors Frameshift Mutations of in Gastric and Colorectal Cancers. Pathol. Oncol. Res. 24, 185–187 (2018). https://doi.org/10.1007/s12253-017-0211-9
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DOI: https://doi.org/10.1007/s12253-017-0211-9