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Trends in the Use of Cardiac Imaging for Women with Newly Diagnosed Breast Cancer

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Abstract

We investigated time trends and factors associated with the use of cardiac imaging among women with early-stage breast cancer prior to the initiation of treatment. Of 11,732 women ages 24–64, diagnosed with stage I–III breast cancer in 2006–2011, 2550 (22%) received anthracycline-based chemotherapy. Baseline cardiac imaging was used in 79% of patients receiving anthracyclines and increased over time. Of 2277 (20%) women who received non-anthracycline therapy, 16% received cardiac imaging. Women receiving cardiac imaging in non-anthracycline therapy group were more likely to have higher cardiovascular risk, as well as higher cancer stage and worse histological tumor grade suggesting that results of imaging might have influenced the choice of cancer therapy. Our findings indicate the need for cardio-oncology collaboration in identification and treatment of women at high risk for adverse oncology and cardiovascular outcomes.

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Acknowledgments

We thank the following persons for facilitating the linkage of cancer registry data for this project: Drs. Tom Tucker and Ms. Jaclyn Nee, Kentucky Cancer Registry; Ms. Lynn Giljahn, Ohio Department of Health; Dr. Maria J. Schymura and Ms. Amy Kahn, NY State Tumor Registry; Drs. A. Rana Bayakly, Georgia Comprehensive Cancer Registry, and Dr. Kevin Ward, Georgia Center for Cancer Statistics; Drs. Rosemary Cress and Arti Parikh-Patel, California Cancer Registry. We also thank Ms. Vasiliki Zotou, programmer analyst at Georgetown, for her assistance with preparing the dataset.

Funding

This work was supported by the National Cancer Institute (R01CA160671 and P30CA051008).

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Authors and Affiliations

  1. MedStar Heart and Vascular Institute, Georgetown University, 110 Irving Street, NW, Ste. 1218, Washington, DC, 20010, USA

    Ana Barac

  2. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA

    Claudine Isaacs, Filipa Lynce & Arnold L. Potosky

  3. Department of Biostatistics and Biomedical Informatics, MedStar Health Research Institute, Hyattsville, MD, USA

    Nawar M. Shara & Sameer Desale

  4. HealthCore, Inc., Wilmington, DE, USA

    Kevin Haynes

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  1. Ana Barac
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  2. Claudine Isaacs
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Correspondence to Ana Barac.

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Conflict of Interest

Dr. Haynes is an employee of HealthCore, Inc., and holds Anthem company stock as part of his employment. Other authors report no conflict of interest relevant to this manuscript.

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Barac, A., Isaacs, C., M. Shara, N. et al. Trends in the Use of Cardiac Imaging for Women with Newly Diagnosed Breast Cancer. J. of Cardiovasc. Trans. Res. 13, 478–489 (2020). https://doi.org/10.1007/s12265-020-10023-6

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  • DOI: https://doi.org/10.1007/s12265-020-10023-6

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