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Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives

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Abstract

New substituted aroylhydrazones (4a-f) were synthesized from the acid hydrazide (3) and the corresponding aldehyde or aldose. 5-Amino-4-cyano-1H-pyrazole derivatives (6a-f) were prepared by the reaction of the aroylhydrazones (4a-f) with malononitrile. The synthesized compounds were tested for antimicrobial activity against various bacteria and fungi and showed moderate to high inhibition activities. Compounds incorporating a sugar moiety as well as a pyrazolyl ring in their structure displayed the highest antimicrobial activity.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Menofeia University, Shebin-El-Koom, 12345, Egypt

    Mohamed T. Abdel-Aal & Abdel-Aleem H. Abdel-Aleem

  2. National Organization of Drug Control and Research, Cairo, 11978, Egypt

    Laila I. Ibahim & Ahmed L. Zein

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  1. Mohamed T. Abdel-Aal
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  2. Abdel-Aleem H. Abdel-Aleem
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  3. Laila I. Ibahim
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  4. Ahmed L. Zein
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Correspondence to Mohamed T. Abdel-Aal.

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Abdel-Aal, M.T., Abdel-Aleem, AA.H., Ibahim, L.I. et al. Synthesis and antimicrobial activity of novel 5-amino-4-cyano-1H-pyrazole and quinazolin-4(3H)-one derivatives. Arch. Pharm. Res. 33, 1891–1900 (2010). https://doi.org/10.1007/s12272-010-1202-5

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  • DOI: https://doi.org/10.1007/s12272-010-1202-5

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