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Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles

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Abstract

Magnetic nanoparticles have been used as drug delivery vehicles against a number of cancer cells. Most of these theranostic formulations have used solid iron oxide nanoparticles (SIONPs) loaded with chemotherapeutics as nano-carrier formulation for both magnetic resonance imaging (MRI) and cancer therapy. In this study, we applied the dopamine-plus-human serum albumin (HSA) method to modify hollow iron oxide nanoparticles (HIONPs) and encapsuated doxorubicin (DOX) within the hollow porous structure of the nano-carrier. The new delivery system can load more drug than solid iron oxide nanoparticles of the same core size using the same coating strategy. The HIONPs-DOX formulation also has a pH-dependent drug release behaviour. Compared with free DOX, the HIONPs-DOX were more effectively uptaken by the multidrug resistant OVCAR8-ADR cells and consequently more potent in killing drug resistant cancer cells. MRI phantom and cell studies also showed that the HIONPs-DOX can decrease the T 2 MRI signal intensity and can be used as a MRI contrast agent while acting as a drug delivery vehicle. For the first time, the dual application of chemo drug transport and MR imaging using the HIONPs-DOX formulation was achieved against both DOX-sensitive and DOX-resistant cancer cells.

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Authors and Affiliations

  1. Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA

    Ruijun Xing, Ashwinkumar A. Bhirde, Shouju Wang, Xiaolian Sun, Yanglong Hou & Xiaoyuan Chen

  2. Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing, 100871, China

    Ruijun Xing

  3. Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361005, China

    Gang Liu

Authors
  1. Ruijun Xing
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  2. Ashwinkumar A. Bhirde
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  3. Shouju Wang
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  4. Xiaolian Sun
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  5. Gang Liu
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  6. Yanglong Hou
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  7. Xiaoyuan Chen
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Correspondence to Xiaoyuan Chen.

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Xing, R., Bhirde, A.A., Wang, S. et al. Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles. Nano Res. 6, 1–9 (2013). https://doi.org/10.1007/s12274-012-0275-5

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  • DOI: https://doi.org/10.1007/s12274-012-0275-5

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