Abstract
Advanced additive manufacture (AM) techniques have been developed to generate three-dimensional (3D) tissue scaffolds with complex topography and controlled internal pore architecture. Among the various AM methods, projection stereolithography (PSL) can be used to fabricate intricate 3D tissue scaffolds that can be engineered to mimic the microarchitecture of tissues. PSL system offers the advantages of enhanced fabrication speed and accuracy compared with conventional stereolithography system. To design and fabricate a complex 3D scaffold, we propose a new projection image generation algorithm that automatically and robustly generates 2D projection image data. The method uses the volumetric distance field (VDF) and triply periodic minimal surface (TPMS) pore morphology. By the creative combination of VDF and TPMS-based pore architecture, we can easily and rapidly generate projection image data for PSL system without using complicated 3D scaffold models. An effective Boolean operation based on VDF was utilized to improve the efficiency of geometrical manipulations required in the scaffold projection image generation. The design results demonstrated that the proposed algorithm can completely alleviate all the limitations and problems of the previous approaches mostly based on time-consuming and error-prone slicing process.
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Yoo, DJ. Advanced projection image generation algorithm for fabrication of a tissue scaffold using volumetric distance field. Int. J. Precis. Eng. Manuf. 15, 2117–2126 (2014). https://doi.org/10.1007/s12541-014-0571-y
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DOI: https://doi.org/10.1007/s12541-014-0571-y