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Haemotoxic Effect of Lead: A Review

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Abstract

Lead exposure is one of the major environmental issues to alter the health and well being of man and animals. Blood being the easy target for lead intoxication shows prominent effects and alteration of several hematological parameters may be regarded as a bio indicator of lead intoxication. Blood lead levels above 10 μg/dL have been associated with numerous manifestations. Anaemia is reported after acute and chronic exposure of lead in both workers of lead factory and in laboratory animals, accomplished either through impairment of heme biosynthesis or by enhanced rate of blood cell destruction. This is confirmed by marked reductions in blood haemoglobin level and haematocrit value and echinocytic transformation of normal erythrocytes after lead exposure. The number of total leucocytes tends to increase with the increase in basophils, eosinophils and lymphocytes possibly due to direct toxic action of lead on leucopoiesis in lymphoid organs. High levels of lead inhibit aggregation of platelets both in human and rat blood. Lead induced changes in the red blood membrane include the changes in lipids and proteins profile of some membrane-associated enzymes or in ions transport mechanisms. The mechanism of lead toxicity may be due, in part, to disruption of calcium-mediated processes. The chronic exposure to lead can result in a drastic changes in the cholesterol and phospholipid content, hexose, hexosamine and sialic acid levels and membrane acetyl cholinesterase, NADH dehydrogenase and Na+–K+ ATPase levels. Moderate exercise, intake of methionine, glycine, curcumin, methionine, carotene and pectin enriched food and vitamin C could reduce the severity of lead toxicity.

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References

  • Ahyayauch, H., W. Sansar, A. Rendon-Ramǐreza, F.M. Goni, Md. Bennouna, and H. Gamrani. 2013. Effects of chronic and acute lead treatments on the biophysical properties of erythrocyte membranes, and a comparison with model membranes. FEBS Open Bio 3: 212–217.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Al-Ali, S.J.K., and A.F. Abdula. 2007. Effect of acute and chronic lead nitrate exposure on some physiological parameters in experimental mice. Basic Journal of Veterinary Research 6(2): 78–88.

    Google Scholar 

  • Albahary, C. 1972. Lead and hemopoiesis. The mechanism and consequences of the erythropathy of occupational lead poisoning. American Journal of Medicine 52: 367–378.

    Article  CAS  PubMed  Google Scholar 

  • Al-Temimi, F.A., P. George, and V. Ankarath. 2002. A case of recurrent abdominal pain. SQU Journal for Scientific Research: Medical Science 4(1): 49–53.

    Google Scholar 

  • Ambali, S.F., M. Angani, M. Shittu, and Md.U. Kawu. 2011. Hematological changes induced by subchronic co-administration of chlorpyrifos and lead in Wistar rats: Alleviating effect of vitamin C. Der Pharmacia Sinica 2(2): 276–284.

    CAS  Google Scholar 

  • ATSDR (Agency for Toxic Substances and Disease Registry). 2007. Case studies in environmental medicine (CSEM) lead toxicity course: WB 1105.

  • Avadheshkumar, R.S. Chauhan, and N.P. Singh. 1998. Immunopathological effect of lead on cell mediated immunity in chicken. Indian Journal of Veterinary Pathology 22(1): 22–25.

    Google Scholar 

  • Baranowska-Bosiacka, I., and A.J. Hlynczak. 2004. Effect of lead ions on rat erythrocyte purine content. Biological Trace Element Research 100: 1–15.

    Article  Google Scholar 

  • Baranowska-Bosiacka, I., A.J. Hlynczak, B. Wiszniewska, and M. Marchlewicz. 2004. Disorders of purine metabolism in human erythrocytes in the state of lead contamination. Polish Journal of Environmental Studies 13(5): 467–476.

    CAS  Google Scholar 

  • Barman, T., R. Kalahasthi, and H.R. Rajmohan. 2014. Effects of lead exposure on the status of platelet indices in workers involved in a lead-acid battery manufacturing plant. Journal of Exposure Science and Environmental Epidemiology 24(6): 629–633.

    Article  CAS  PubMed  Google Scholar 

  • Behrens, J., and J. Brooks. 2000. Wind in their wings: The condor recovery program. Endangered Species Bulletin 25: 8–9.

    Google Scholar 

  • Bellom-Ohvi, L., M. Annadata, G.W. Goldstein, and J.P. Bressler. 1996. Phosphorylation of membrane proteins in erythrocytes treated with lead. Biochemical Journal 315: 401–406.

    Article  Google Scholar 

  • Bijoor, A.R., and T. Venkatesh. 2007. Genetic susceptibility to lead poisoning—A case report. Indian Journal of Clinical Biochemistry 22(2): 162–163.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bressler, J., K.A. Kim, T. Chakraborti, and G. Goldstein. 1999. Molecular mechanisms of lead neurotoxicity. Neurochemistry Research 24: 595–600.

    Article  CAS  Google Scholar 

  • Burco, J., A.M. Myers, K. Schuler, and C. Gillin. 2012. Acute lead toxicosis via ingestion of spent ammunition in a free-ranging cougar (Puma concolor). Journal of Wildlife Diseases 48(1): 216–219.

    Article  PubMed  Google Scholar 

  • Burger, J., and M. Gochfeld. 2005. Effects of lead on learning in herring gulls: An avian wildlife model for neurobehavioral deficits. Neurotoxicology 26(4): 615–624.

    Article  CAS  PubMed  Google Scholar 

  • Calderon-Sahnas, J.V., M.A. Quintanar-Escorza, C.E. Hernandez-Luna, and M.T. Gonzales-Martmez. 1999. Effect of lead on the calcium transport in human erythrocyte. Human Experimental Toxicology 18: 146–153.

    Article  Google Scholar 

  • Campagna, D., G. Huel, F. Girard, J. Sahuquillo, and P. Blot. 1999. Environmental lead exposure and activity of δ-aminolevulinic acid dehydratase (ALA-D) in maternal and cord blood. Toxicology 134(2–3): 143–152.

    Article  CAS  PubMed  Google Scholar 

  • Camus, A.C., M. Mark, D. Mitchelaln, and J.E. Williams. 1998. Elevated lead levels in farmed american alligators Alligator mississippiensis consuming nutria Myocastor coypus meat contaminated by lead bullets. Journal of the World Aquaculture Society 29: 370–376.

    Article  Google Scholar 

  • Cheson, B.D., W.N. Rom, and R.C. Webber. 1984. Basophilic stippling of red blood cells: A non-specific finding of multiple etiology. American Journal of Industrial Medicine 5: 327.

    Article  CAS  PubMed  Google Scholar 

  • Chiu, Y.W., T.Y. Liu, and H.Y. Chuang. 2013. The effects of lead exposure on the activities of δ-amino levulinic acid dehydratase with the modification of the relative genotypes. In E3S Web of conferences, vol. 1, 26005.

  • Church, M.E., R. Gwiazda, R.W. Risebrough, K. Sorenson, C.P. Chamberlain, S. Farry, W. Heinrich, B.A. Rideout, and D.R. Smith. 2006. Ammunition is the principal source of lead accumulated by California condors re-introduced to the wild. Environmental Science and Technology 40: 6143–6615.

    Article  CAS  PubMed  Google Scholar 

  • Clark, A.J., and A.M. Scheuhammer. 2003. Lead poisoning in upland-foraging birds of prey in Canada. Ecotoxicology 12: 23–30.

    Article  CAS  PubMed  Google Scholar 

  • Craighead, D., and B. Bedrosian. 2008. Blood lead levels of common ravens with access to big-game offal. Journal of Wildlife Management 72(1): 240–245.

    Article  Google Scholar 

  • Cruz-Martinez, L., P.T. Redig, and J. Deen. 2012. Lead from spent ammunition: a source of exposure and poisoning in bald eagles. Human-Wildlife Interactions 6: 94–104.

    Google Scholar 

  • De Francisco, N., J.D. Ruiz Troya, and E.I. Agüera. 2003. Lead and lead toxicity in domestic and free living birds. Avian Pathology 32(1): 3–13.

    Article  PubMed  CAS  Google Scholar 

  • Dongre, N.N., N. Adinath, A. Suryakar, J. Patil, J.G. Ambekar, and D.B. Rathi. 2011. Biochemical effects of lead exposure on systolic and diastolic blood pressure, heme biosynthesis and hematological parameters in automobile workers of north Karnataka (India). Indian Journal of Clinical Biochemistry 26(4): 400–406.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Farhat, A.S., and G. Khademi. 2015. Blood lead level and seizure: a narrative review. Reviews in Clinical Medicine 2(2): 84–87.

    Google Scholar 

  • Fisher, I.J., D.J. Pain, and V.G. Thomas. 2006. A review of lead poisoning from ammunition sources in terrestrial birds. Biology of Conservation 131(3): 421–432.

    Article  Google Scholar 

  • Flora, G., D. Gupta, and A. Tiwari. 2012. Toxicity of lead: A review with recent updates. Interdisciplinary Toxicology 5(2): 47–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Franson, J.C. 1996. Interpretation of tissue lead residues in birds other than waterfowl. In Environmental contaminants in wildlife–Interpreting tissue concentrations, ed. W.N. Beyer, G.H. Heinz, and A.W. Redmon-Norwood, 265–279. Boca Raton, FL: CRC.

    Google Scholar 

  • Froom, P., E. Kristal-Boneh, J. Benbassat, R. Ashkanazi, and J. Ribak. 1999. Lead exposure in battery-factory workers is not associated with anemia. Journal of Occupational and Environmental Medicine 41: 120–123.

    Article  CAS  PubMed  Google Scholar 

  • Gangoso, L., P. Álvarez-Lloret, A.B. Alejandro, R. Navarro, R. Mateo, F. Hiraldo, and J.A. Donázar. 2009. Long-term effects of lead poisoning on bone mineralization in vultures exposed to ammunition sources. Environmental Pollution 157: 569–574.

    Article  CAS  PubMed  Google Scholar 

  • Golalipour, M.J., D. Roshandel, G. Roshandel, S. Ghafari, M. Kalavi, and K. Kalavi. 2007. Effect of lead intoxication and d-penicillamine treatment on hematological indices in rats. International Journal of Morphology 2S(4): 717–722.

    Google Scholar 

  • Goldstein, G.W. 1993. Evidence that lead acts as a calcium substitute in second messenger metabolism. Neurotoxicology 14: 97–102.

    CAS  PubMed  Google Scholar 

  • Grandjean, P., B.M. Jensen, S.H. Sando, P.J. Jørgensen, and S. Antonsen. 1989. Delayed blood regeneration in lead exposure: An effect on reserve capacity. American Journal of Public Health 79: 1385–1388.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gurer, H., H. Ozgunes, R. Neal, D.R. Spitz, and N. Ercal. 1998. Antioxidant effects of N acetylcysteine and succimer in red blood cells from lead exposed rats. Toxicology 128: 181–182.

    Article  CAS  PubMed  Google Scholar 

  • Hammond, P.B., R.L. Bornschein, and P.A. Succop. 1985. Dose–effect and dose–response relationships of blood lead to erythrocytic protoporphyrin in young children. Environmental Research 38: 187–196.

    Article  CAS  PubMed  Google Scholar 

  • Hernberg, S. 2000. Lead poisoning in a historical perspective. American Journal of Industrial Medicine 38: 244–254.

    Article  CAS  PubMed  Google Scholar 

  • Holem, R.R., W.A. Hopkins, and L.G. Talent. 2006. Effect of acute exposure to malathion and lead on sprint performance of the western fence lizard (Sceloporus occidentalis). Archives of Environment Contamination Toxicology 51(1): 111–116.

    Article  CAS  Google Scholar 

  • Honguchi, S., S. Matsumura, K. Fukumoto, I. Karai, G. Endo, K. Teramoto, K. Shmagawa, I. Kiyota, F. Wakitam, and S. Takise. 1991. Erythrocyte deformability in workers exposed to lead. Osaka City Medical Journal 37: 149–155.

    Google Scholar 

  • Hwang, K.Y., B.S. Schwartz, B.K. Lee, P.T. Strickland, A.C. Todd, and J.P. Bressler. 2001. Associations of lead exposure and dose measures with erythrocyte protein kinase C activity in 212 current Korean lead workers. Toxicological Sciences 62: 280–288.

    Article  CAS  PubMed  Google Scholar 

  • Jang, W.H., K.M. Lin, K. Kim, J.Y. Noh, S. Kang, Y.K. Chang, and J.H. Chung. 2011. Low level of lead can induce phosphatidylserine exposure and erythrophagocytosis. Toxicological Science 122: 177–184.

    Article  CAS  Google Scholar 

  • Janssen, D.L., J.E. Oosterhuis, J.L. Allen, M.P. Anderson, D.G. Kelts, and S.N. Wiemeyer. 1986. Lead poisoning in free ranging California Condors. Journal of the American Veterinary Medical Association 189: 1115–1117.

    CAS  PubMed  Google Scholar 

  • Janssens, E., T. Dauwe, E. Van Duyse, J. Beernaert, R. Pinxten, and M. Eens. 2003. Effects of heavy metal exposure on aggressive behavior in a small territorial songbird. Archives of Environmental Contamination and Toxicology 45: 121–127.

    Article  CAS  PubMed  Google Scholar 

  • Jehan, Z.S., and D.B. Motlag. 1995. Metal induced changes m the erythrocyte membrane of rats. Toxicological Letters 78: 127–133.

    Article  CAS  Google Scholar 

  • Karita, K., E. Yano, M. Dakeishi, T. Iwata, and K. Murata. 2005. Benchmark dose of lead inducing anemia at the workplace. Risk Analysis 25(4): 957–962.

    Article  PubMed  Google Scholar 

  • Kasperczyk, A., G. Machnik, M. Dobrakowski, D. Sypniewski, E. Birkner, and S. Kasperczyk. 2012. Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead. Toxicology 301(1–3): 79–84.

    Article  CAS  PubMed  Google Scholar 

  • Kelada, S.N., E. Shelton, R.B. Kaufmann, and M.J. Khoury. 2001. d-Aminolevulinic acid dehydratase genotype and lead toxicity. American Journal of Epidemiology 154(1): 1–13.

    Article  CAS  PubMed  Google Scholar 

  • Kelly, T.R., and C.K. Johnson. 2011. Lead exposure in free-flying turkey vultures is associated with big game hunting in California. PLoS ONE 6(4): e15350. doi:10.1371/journal.pone.0015350.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kempe, D.S., P.A. Lang, K. Eisele, B.A. Klarl, T. Wieder, S.M. Huber, C. Duranton, and F. Lang. 2005. Stimulation of erythrocyte phosphatidylserine exposure by lead ions. American Journal of Physiology and Cell Physiology 288: C396–C402.

    Article  CAS  PubMed  Google Scholar 

  • Kenntner, N., F. Tataruch, and O. Krone. 2001. Heavy metals in soft tissue of White tailed Eagles found dead or moribund in Germany and Austria from 1993 to 2000. Environmental Toxicology and Chemistry 20: 1831–1837.

    Article  CAS  PubMed  Google Scholar 

  • Klassen, C.D. 2001. Casarett and Doull’s toxicology: The basic science of poisons, 6th ed, 812–841. New York: McGraw-Hill.

    Google Scholar 

  • Lamola, A.A., S. Piomelli, M.B. Poh-Fitzpatric, T. Yamane, and L.C. Harbor. 1975. Erythropoietic protoporphyria and lead intoxication: The molecular basis for difference in cutaneous photosensitivity. II. Different binding of erythrocyte protoporphyrin to hemoglobin. Journal of Clinical Investigation 56: 1528–1535.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • LEAD Group Incorporated ABN. 2010. Fact sheet: Nutrients that reduce lead poisoning. 1–10. http://www.lead.org.au/fs/Fact_sheetNutrients_that_reduce_lead_poisoning_June_2010.pdf.

  • Li, W., S. Han, T.R. Gregg, F.W. Kemp, A.L. Davidow, D.B. Louria, A. Siegel, and J.D. Bogden. 2003. Lead exposure potentiates predatory attack behavior in the cat. Environmental Research 92: 197–206.

    Article  CAS  PubMed  Google Scholar 

  • López, J.P., A. de la Peña, and G. Baños de MacCarthy. 1992. Effect of lead and cadmium on platelet aggregation. Archivo del Instituto de cardiologica de Mexico 62(4): 317–324.

    Google Scholar 

  • Makino, S., Y. Shimizu, and T. Takata. 1997. A study on the relationship between blood lead levels and anemia indicators in workers exposed to low levels of lead. Industrial Health 35: 537–541.

    Article  CAS  PubMed  Google Scholar 

  • Marchetti, C. 2003. Molecular targets of lead in brain neurotoxicity. Neurotoxicity Research 5: 221–236.

    Article  PubMed  Google Scholar 

  • Mateo, R., R. Cadenas, M. Manez, and R. Guitart. 2001. Lead shot ingestion in two raptor species from Doñana, Spain. Ecotoxicology and Environmental Safety 48: 6–10.

    Article  CAS  PubMed  Google Scholar 

  • Meretsky, V.J., N.F.R. Snyder, S.R. Beissinger, D.A. Clendenen, and J.W. Wiley. 2000. Demography of the California Condor: Implications for re-establishment. Conservation Biology 14: 957–967.

    Article  Google Scholar 

  • Mohammadi M., R. Ghaznavi, R. Keyhanmanesh, H. R. Sadeghipour, R. Naderi and H. Mohammadi. 2013. Exercise prevents lead-induced elevation of oxidative stress and inflammation markers in male rat blood. The Scientific World Journal 2013, Article ID 320704.

  • Mojzis, J., and F. Nistiar. 2001. Lead-induced changes of cation-osmotic hemolysis in rats. General Physiology and Biophysics 20: 315–319.

    CAS  PubMed  Google Scholar 

  • Mokken, F.C., M. Kedaria, C.P. Henny, M.R. Hardeman, and A.W. Gelb. 1992. The clinical importance of erythrocyte deformability, a hemorrheological parameter. Annals of Hematology 64: 113–122.

    Article  CAS  PubMed  Google Scholar 

  • Naidu, K.A. 2003. Vitamin C in human health and disease is still a mystery? An overview. Nutrition Journal 2: 7–16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ohyashiki, T., M. Kobayashi, and K. Mashi. 1991. Oxygen-radical-mediated lipid peroxidation and inhibition of ADP-induced platelet aggregation. Archives of Biochemistry and Biophysics 228: 282–286.

    Article  Google Scholar 

  • Onalja, A.O., and L. Claudio. 2000. Genetic susceptibility to lead poisoning. Environmental Health Perspective 108(1): 23–28.

    Article  Google Scholar 

  • Owolabi, J.O., E. Opoola, and E.A. Caxton-Martins. 2012. Healing and prophylactic effects of Moringa oleifera leaf extract on lead induced damage to haematological and bone marrow elements in adult Wistar rat models. Open Access Scientific Reports 1: 386. doi:10.4172/scientificreports.386.

    Google Scholar 

  • Paglia, D.E., W.N. Valentine, and J.G. Dahlgren. 1975. Effects of low-level lead exposure on pyrimidine 5′-nucleotidase and other erythrocyte enzymes. Possible role of pyrimidine 5′-nucleotidase in the pathogenesis of lead-induced anemia. The Journal of Clinical Investigation 56: 1164–1169.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Patrick, L. 2006. Lead toxicity, a review of the literature: Part I: Exposure, evaluation, and treatment. Alternative Medicine Review 11: 2–22.

    PubMed  Google Scholar 

  • Pattee, O.H., and D.J. Pain. 2003. Lead in the environment. In Handbook of ecotoxicology, 2nd ed, ed. D.J. Hoffman, B.A. Rattner, G.A. Burton Jr, and J. Cairns Jr, 373–408. New York, NY: Lewis Publishers.

    Google Scholar 

  • Piomelli, S., C. Seaman, D. Zullow, A. Curran, and B. Davidow. 1982. Threshold for lead damage to heme synthesis in urban children. Proceedings of National Academy of Sciences USA 79: 3335–3339.

    Article  CAS  Google Scholar 

  • Platt, S.R., K.E. Helmick, J. Graham, R.A. Bennett, L. Phillips, C.L. Chrisman, and P.E. Ginn. 1999. Peripheral neuropathy in a Turkey Vulture with lead toxicosis. Journal of the American Veterinary Medical Association 214: 1218–1220.

    CAS  PubMed  Google Scholar 

  • Pokras, M.A., and R. Chafel. 1992. Lead toxicosis from ingested fishing sinkers in adult Common Loons (Gavia immer) in New England. Journal of Zoo and Wildlife Medicine 23: 92–97.

    Google Scholar 

  • Pokras, M.A., and M.R. Kneeland. 2009. Understanding lead uptake and effects across species lines: A conservation medicine based approach. In Ingestion of lead from spent ammunition: implications for wildlife and humans, ed. R.T. Watson, M. Fuller, M. Pokras, and W.G. Hunt, 7–22. Boise, ID: The Peregrine Fund.

    Google Scholar 

  • Pounds, J.G. 1984. Effect of lead intoxication on calcium homeostasis and calcium-mediated cell function: A review. Neurotoxicology 5: 295–332.

    CAS  PubMed  Google Scholar 

  • Rabinowitz, M.B., A. Leviton, and H.L. Needleman. 1986. Occurrence of elevated protoporphyrin levels in relation to lead burden in infants. Environmental Research 39: 253–257.

    Article  CAS  PubMed  Google Scholar 

  • Ray, R.R., and N.K. Sarkar. 2013. Lead (Pb) induced anaemia in swiss mice-light and scanning electron microscopic studies. International Journal of Pharma and Bio Sciences 4(1B): 22–30.

    CAS  Google Scholar 

  • Roels, H.A., and R. Lauwerys. 1987. Evaluation of dose–effect and dose–response relationships for lead exposure in different Belgian population groups (fetus, child, adult men and women). Journal of Trace Elements in Medicine and Biology 4(2): 80–87.

    CAS  Google Scholar 

  • Romeo, R., C. Aprea, P. Boccalon, D. Orsi, B. Porcelli, and P. Sartorelli. 1996. Serum erythropoietin and blood lead concentrations. International Archives of Occupational and Environmental Health 69: 73–75.

    Article  CAS  PubMed  Google Scholar 

  • Rossi, E. 2008. Low level environmental lead exposure—A continuing challenge. Clinical and Biochemical Review 29: 63–70.

    Google Scholar 

  • Rous, P. 2000. The effect of heavy metals boundary contaminated soil on haematological and selected biochemical parameters in blood plasma of rabbits. Acta-Universitatis-Agriculturae-et-Silviculturae-Mendelianae-Brunensis 48(3): 93–99.

    CAS  Google Scholar 

  • Salawu, E.O. 2010. Lycopersicon esculentum (tomato) prevents adverse effects of lead on blood constituents. Malaysian Journal of Medical Science 17(3): 13–18.

    Google Scholar 

  • Scheuhammer, A.M., and S.L. Norris. 1995. A review of the environmental impacts of lead shotshell ammunition and lead fishing weights in Canada. Canadian Wildlife Service Occasional. Paper No. 88, Ottawa, Canada.

  • Schwartz, J., P.J. Landrigan, E.L. Baker, W.A. Orenstein, and I.H. von Lindern. 1990. Lead-induced anemia: Dose–response relationships and evidence for a threshold. American Journal of Public Health 80(2): 165–168.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sciarillo, W.G., G. Alexander, and K.P. Farrell. 1992. Lead exposure and child behavior. American Journal of Public Health 82: 1356–1360.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Selevan, S.G., D.C. Rice, K.A. Hogan, S.Y. Euling, A. Pfahles-Hutchens, and J. Bethel. 2003. Blood lead concentration and delayed puberty in girls. The New England Journal of Medicine 348(16): 1527–1536.

    Article  CAS  PubMed  Google Scholar 

  • Shah, S.L., and A. Altindog. 2005. Alteration in the immunological parameters Tench (Tinca tinca L. 1758) after acute and chronic exposure to lethal and sublethal treatments with mercury, cadmium and lead. Turkish Journal of Veterinary and Animal Sciences 29: 1163–1168.

    CAS  Google Scholar 

  • Sharma, R., K. Panwar, and S. Mogra. 2012. Effects of prenatal and neonatal exposure to lead on white blood cells in Swiss mice. Journal of Cell and Molecular Biology 10(1): 33–40.

    CAS  Google Scholar 

  • Sidor, I.F., M.A. Pokras, A.R. Major, R.H. Poppenga, K.M. Taylor, and R.M. Miconi. 2003. Mortality of common loons in New England, 1987–2000. Journal of Wildlife Diseases 39: 306–315.

    Article  PubMed  Google Scholar 

  • Sileo, L., and S.I. Fefer. 1987. Paint chip poisoning of Laysan Albatross at Midway Atoll. Journal of Wildlife Diseases 23: 432–437.

    Article  CAS  PubMed  Google Scholar 

  • Simons, T.J. 1993. Lead–calcium interactions in cellular lead toxicity. Neurotoxicology 14: 77–85.

    CAS  PubMed  Google Scholar 

  • Slobozhanina, E.I., N.M. Kozlova, L.M. Lukyanenko, O.B. Oleksiuk, R. Gabbianelli, D. Fedeli, G.C. Caulini, and G. Falcioni. 2005. Lead-induced changes in human erythrocytes and lymphocytes. Applied Toxicology 25(2): 109–114.

    Article  CAS  Google Scholar 

  • Stauber, E., N. Finch, P.A. Talcott, and J.M. Gay. 2010. Lead poisoning of bald (Haliaeetus leucocephalus) and golden (Aquila chrysaetos) eagles in the U.S. inland Pacific northwest region—An 18-year retrospective study: 1991–2008. Journal of Avian Medicine and Surgery 24(4): 279–287.

    Article  PubMed  Google Scholar 

  • Suradkar, S.G., D.J. Ghodasara, P. Vihol, J. Patel, V. Jaiswal, and K.S. Prajapati. 2009. Haemato-biochemical alterations induced by lead acetate toxicity in Wistar rats. Veterinary World 2(11): 429–431.

    Google Scholar 

  • Tanquerel des Planches, L. 1850. Lead diseases: A treatise. Boston, MA: Tappan, Whittemore and Mason.

    Google Scholar 

  • Terayama, K. 1993. Effects of lead on electrophoretic mobility, membrane sialic acid, deformability and survival of rat erythrocytes. Industrial Health 31: 113–126.

    Article  CAS  PubMed  Google Scholar 

  • Tola, S. 1975. Occupational lead exposure in Finland: IV. The polyvinyl chloride plastic industry. Scandinavian Journal of Work, Environment and Health 1: 173–177.

    Article  CAS  PubMed  Google Scholar 

  • Toscano, C.D., and T.R. Guilarte. 2005. Lead neurotoxicity: From exposure to molecular effects. Brain Research Reviews 49: 529–554.

    Article  CAS  PubMed  Google Scholar 

  • US Department of Health and Human Services. (2000). WHO Training Package for the Health Sector. http://ec.europa.eu/health/ph_projects/2003/action3/docs/2003_3_09_a11_en.pdf.

  • Valentine, W.N., D.E. Paglia, K. Fink, and G. Madokoro. 1976. Association with hemolytic anemia, basophilic stippling, erythrocyte pyrimidine 5′-nucleotidase deficiency, and intraerythrocytic accumulation of pyrimidinase. Journal of Clinical Investigation 58: 926–932.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valentine, J.L., R.W. Baloh, B.L. Browdy, H.C. Gonick, C.P. Brown, G.H. Spivey, and B.D. Culver. 1982. Subclinical effects of chronic increased lead absorption—A prospective study. Part IV. Evaluation of heme synthesis effects. Journal of Occupational Medicine 24: 120–125.

    CAS  PubMed  Google Scholar 

  • Vaziri, N.D., C.Y. Lin, F. Farmand, and R.K. Sindhu. 2003. Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension. Kidney International 63(1): 186–194.

    Article  CAS  PubMed  Google Scholar 

  • Wayland, M., and T. Bollinger. 1999. Lead exposure and poisoning in bald eagles and golden eagles in the Canadian Prairie Provinces. Environmental Pollution 104(3): 341–350.

    Article  CAS  Google Scholar 

  • Wibowo, M.D., H.J.A. Sallé, P. del Castilho, and R.L. Zielhuis. 1979. An effect of erythrocyte protoporphyrin on blood manganese in lead-exposed children and adults. International Archives of Occupational and Environmental Health 43(3): 177–182.

    Article  CAS  PubMed  Google Scholar 

  • Wildemann, T.M., N. Mirhosseini, S.D. Siciliano, and L.P. Weber. 2015. Cardiovascular responses to lead are biphasic, while methyl mercury, but not inorganic mercury, monotonically increases blood pressure in rats. Toxicology 328: 1–11.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, X., L. Yang, Y. Li, H. Li, W. Wang, and B. Ye. 2012. Impacts of lead/zinc mining and smelting on the environment and human health in China. Environmental Monitoring and Assessment 184: 2261–2273.

    Article  CAS  PubMed  Google Scholar 

  • Zook, B.C., J.L. Carpenter, and E.B. Leeds. 1969. Lead poisoning in dogs. Journal of American Veterinary Medical Association 155(8): 1329–1342.

    CAS  Google Scholar 

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  1. Department of Zoology, Bethune College, 181, Bidhan Sarani, Kolkata, 700 006, India

    Rina Rani Ray

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  1. Rina Rani Ray
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Correspondence to Rina Rani Ray.

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Ray, R.R. Haemotoxic Effect of Lead: A Review. Proc Zool Soc 69, 161–172 (2016). https://doi.org/10.1007/s12595-015-0160-9

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  • DOI: https://doi.org/10.1007/s12595-015-0160-9

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