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Hyaluronic Acid/Oxidized К-Carrageenan Electrospun Nanofibers Synthesis and Antibacterial Properties

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Abstract

The current examination is relating to building up a novel nanofiber wound dressing including hyaluronic acid (HA)/oxidized К-carrageenan (OKC) for biomedical application. Until now, electrospinning of К-carrageenan (КC) has fizzled, because of its high-hydrophilic nature, its shaping gel partiality. To beat this problem, KC is exposed to oxidation, by means of sodium periodate (NaIO4). The ideal conditions are NaIO4 to КC 0.5:1; temperature, 40 °C; time, 3 h; and pH 3. OКC was mixed with HA and polyvinyl alcohol (PVA) for delivering electrospun arrangement, which is at long last manufactured to frame nanofiber, utilizing electrospinning setup. The created nanofiber was evaluated by SEM and FTIR spectroscopy, and measuring antibacterial properties was likewise assessed. SEM pictures uncovered that the mixing proportion 2.5:2.5:5 of HA, OКC, and PVA individually accomplished uniform, normal, and globule-free nano-filaments. The outcomes showed likewise that all nano-filaments have antibacterial properties against Gram-positive and Gram-negative microbes, which is elevated to be utilized effectively in biomedical applications.

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Data Availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors acknowledge the National Research Center, Textile Research Division, Central Lab, for its technical support.

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  1. Pre-Treatment and Finishing of Cellulosic Based Fibers Department, Textile Industries Research Division, National Research Center, 33 El- Behooth St, Giza, 12311, Egypt

    A. Abou-Okeil, H. M. Fahmy, Moustafa M. G. Fouda, A. A. Aly & H. M. Ibrahim

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  1. A. Abou-Okeil
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Correspondence to A. Abou-Okeil.

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Abou-Okeil, A., Fahmy, H.M., Fouda, M.M.G. et al. Hyaluronic Acid/Oxidized К-Carrageenan Electrospun Nanofibers Synthesis and Antibacterial Properties. BioNanoSci. 11, 687–695 (2021). https://doi.org/10.1007/s12668-021-00884-9

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