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Review of experimental and clinical studies on Soyangin (少陽人) Yanggyeoksanhwa-tang (凉膈散火湯) in Korea since 2000

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Abstract

This paper was aimed to review experimental and clinical studies on Yanggyeoksanhwa-tang (YGSH; 凉膈散火湯), figuring out the recent tendency and suggesting the future prospects of YGSH-related studies. The articles published in 19 journals of Korean Medicine since 2000 were searched, screened, and classified into experimental or clinical studies. And we structured designs, methods and results of the included studies into each table for the experimental studies or the clinical studies. Especially tools to diagnose constitutions and patterns identified in clinical researches were also summarized in the tables. Thirty-five articles were finally included. Sixteen experimental studies were mostly in vivo designs to show the efficacy of YGSH in stroke patients. There were only two studies for the safety. The efficacy was measured physically and chemically depending on the target diseases. Seventeen case studies mostly targeted stroke, too. The pattern identified in the reports varied from Chest-Heat congested (Hyunggyeok-yeol) Symptomatology (胸膈熱病) to Stomach Heat-based Interior Heat (Wesuyeol-liyeol) Disease (胃受熱裏熱病) or Upper Wasting-Thirst (Sangso) Pattern (上消證) of Soyangin (少陽人). The evaluations of outcomes were carried out mostly with symptomatic change except for a few studies. A controlled clinical trial reported the effectiveness of YGSH in the patients with cerebral infarction, while a before & after study with diabetes. Well-designed randomized controlled trials should be performed in the future in order to obtain higher level of evidences for using YGSH.

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References

  • Bae EJ, Lee HC, Lee SW, Park SU, Yoon SW, Ko CN (2003) The case report of abtipsycotropic drug-induced extrapyramidal symptoms patient. Korean J Orient Int Med fal.:82–90

  • Bae YC, Park HS, Kim HS, Kim KW, Won KS (2002) Study on the relationship of change in EKG and Yangkyuksanhwa-tang. J Sasang Const Med 14(3):85–96

    Google Scholar 

  • Bae YC, Lee SM, Yoo GS, Joo JC, Baek DG (2004) A case of persistent hiccup healed by Soyangin herbal medicines. J Sasang Const Med 16(2):105–113

    Google Scholar 

  • Bae JG, Lee HE, Ahn TW (2009) Two cases of Soyangin dermatitis patients treated with Yangkyuksanhwa-tang. J Sasang Const Med 21(3):193–201

    Google Scholar 

  • Boo IG, Kim YS (2007) Immunohistochemical study of Yanggyuksanhwa-tang on focal cerebral ischemia of diabetic rats. J Korean Orient Physiol Pathol 21(3):741–747

    Google Scholar 

  • Cho SW, Park SS (2001) Effects of Yangkyuksanhwa-tang on the allergic contact dermatitis. J Sasang Const Med 13(3):89–101

    Google Scholar 

  • Choi JR, Bae HS, Han KS, Choi JY, Park SS (2002) A case study about paraplegia diagnosed as spinal cord infarction. J Sasang Const Med 14(2):160–168

    Google Scholar 

  • Choi AR, Ha JH, Lee JH, Jang WS, Goo DM (2008) A clinical study on strabismus patient of abducence nerve paralysis in Soyangin improved with Yangkyuksanhwa-tang. J Sasang Const Med 20(3):176–183

    Google Scholar 

  • Dept. of Sasang Constitutional Med. All Cols. of Korean Med. in Korea(compilation) (2012) The revised and enlarged Sasang Constitutional medicine. Jipmoondang, Seoul

    Google Scholar 

  • Dept. of Sasang Constitutional Med. College of Korean Med. Kyung-Hee Univ (2010) The clinical guide book for Sasang Constitutional medicine: The literature on Sasang Constitutional medicine, 2nd edn. Hanmi Medical Publishing, Seoul

    Google Scholar 

  • Ha HK, Jin SE, Shin HK (2012) In vitro inhibitory effects of Yangguksanhwa-tang and Taeumjowi-tang on CYP450 isozymes. Korean J Orient Prevent Med Soc 16(3):129–137

    Google Scholar 

  • Jeong YJ, Lim JN, Lee TG, Kim SB, Koh BH, Song IB (2003) A case of drug eruptions of Soyangin patient misrated with Taeumin. J Sasang Const Med 15 (1):118–122

  • Jun HJ, Lee JH, Nam SS, Kim YS (2001) A case of sequelae of septic arthritis treated by the therapy of oriental medicine. J Korean Acupunct Moxibustion Soc 18(5):204–212

    Google Scholar 

  • Jung SI, Kim JW (2002) Clinical study about the diabetes mellitus patients administration of Yangkyuksanwha-tang. J Korean Orient Physiol Pathol 16(6):1308–1313

    Google Scholar 

  • Jung DY, Ha HK, Lee HY, Lee J, Lee NH, Lee JK, Huang DS, Shin HK (2010) Stimulation of the immune response by Yanggyuksanhwa-tang. J Sasang Const Med 22(4):77–84

    Google Scholar 

  • Kim EJ, Kim YS (2007) Effects of Yanggyuksanhwa-tang on diabetic rats induced by streptozotocin. J Korean Orient Physiol Pathol 21(2):474–478

    Google Scholar 

  • Kim EJ, Kim YS (2008) Effects of Yanggyuksanhwa-tang on global cerebral ischemia of diabetic rats induced by streptozotocin. J Korean Orient Physiol Pathol 22(2):321–327

    Google Scholar 

  • Kim DJ, Park MY, Kim SM, Kwak MA, Kim JD, Choi HY (2001) A clinical report on the Byun-jo had grown worse after cerebral infarction of patient treated with Soyangin Yanggueksanwha-tang. Korean J Orient Int Med 22(4):749–754

    Google Scholar 

  • Kim H, Yang SM, Kim DL (2002a) A clinical study of the treatment prescibed Yanggyuksanhwa-tang for an insomnia concurred in Soyangin with stroke. J Sasang Const Med 14(3):167–173

    Google Scholar 

  • Kim HS, Park S-H, Bae YC, Ju JC (2002b) A case study about treatment of Soyangin patient diagnosed as ICH without operated. J Sasang Const Med 14(2):106–114

    Google Scholar 

  • Kim JY, Kim EJ, Kim YS, Bae HS, Lee KS (2002c) Two cases of chest fever with dysphoria in stroke patients treated with Yangkyuksanhoa-tang. Korean J Orient Int Med 23(2):292–297

    Google Scholar 

  • Kim SJ, Kim MS, Seo BI, Gu DM, Seo HG, An HD (2003a) One case report of urinary and bowel dysfunction treated with Yangkyuksanwha-tang in cerebrovascular accident patient. Korean J Herbology 18(3):1–8

    Google Scholar 

  • Kim SJ, Shin JW, Sohn YJ, Jung HS, Won R, Sohn NW (2003b) Effect of Yanggyuksanhwa-tang on c-fos and c-jun expression in ischemic damaged hippocampus of aged BCAO rats. Korean J Orient Int Med 24(2):337–347

    Google Scholar 

  • Kim SA, Eum HS, Jung WS, Seo UK, Kang YH (2004) Case report on a posterior cerebral artery infarction patient with visual and cognitive abnormalities. Korean J Orient Int Med 25(4–2):433–441

    Google Scholar 

  • Kweon DY, Kim KY (2000) Studies on the regulatory effect of cytokine production in patients with cerebral infarction by Yangkyuksanhwa-tang. J Sasang Const Med 12(2):153–161

    Google Scholar 

  • Lee JH, Shin MR (2011) The study of the hyperhidrosis patient treated with Yanggyuksanhwa-tang. J Sasang Const Med 23(4):526–532

    Google Scholar 

  • Lee HS, Kang TG, Kim JJ, Han KS, Bae HS, Park SS (2006) A case study of the Creutzfelt Jacob disease suspected patient. J Sasang Const Med 18(2):139–147

    Google Scholar 

  • Lee HS, Park SJ, Jung KS, Sohn YJ, Jung HS, Park DI, Sohn NW (2008a) Effect of Yanggyuksanhwa-tang on ischemic damage in organotypic hippocampal slice culture. Korean J Orient Int Med 29(1):231–242

    Google Scholar 

  • Lee SY, Choi AR, Ha JH, Lee JH, Kim PJ, Goo DM (2008b) An experimental study on the anti-stress effect by Soyangin Hyeongbangdojeok-san and Yanggyeoksanhwa-tang. J Sasang Const Med 20(3):151–163

    Google Scholar 

  • Lim MH, Lee TH, Oh YS, Choi WS, Kwak MA, Park MY, Kim SM, Park JH (2003) Two cases of cerebral infarction patients prescribed Yanggyeoksanhwa-tang show symptom's improvement alongside of tongue's figure changes. Korean J Orient Int Med spr.:142–153

  • Lo HS, Lee SM, Bae YC, Park SH, Lee JH, Song SY, Yoo KS, Joo JC (2004) The effect of Yangkyuksanhwa-tang on cytokine production in the patients with cerebral infarction. J Sasang Const Med 16 (1):120–129

  • Ma JY, Huang DS, Seo CS, Lee SW, Kim JY, Shin HK (2009) Acute toxicity study on Yangkyuksanhwa-tang in mice. J Sasang Const Med 21(3):131–137

    Google Scholar 

  • Oh KH, Lee WC (2006) Neuroprotective effect Yanggyuksanhwa-tang on cerebral infarction induced by MCAO in hyperlipidemic rats. Korean J Orient Int Med 27(4):915–926

    Google Scholar 

  • Park EK, Shin JW, Sohn YJ, Jung HS, Won R, Shon NW (2003) Effect of Yanggyuksanhwa-tang on pyramidal neuron and HSP72 expression in ischemic damaged hippocampus of aged BCAO rats. J Korean Orient Physiol Pathol 17(3):791–797

    Google Scholar 

  • Park BJ, Lee JH, Lee EJ, Koh BH (2011) The origin, changesm and compositive principles of Yanggyeoksanhwa-tang . J Sasang Const Med 23(2):184–193

  • Service HIRA (2013) DAMI & RoBANS ver 2.0 by HIRA(G000M51-2013-54). Health Insurance Review & Assessment Service, Seoul

    Google Scholar 

  • Sohn CH, Shin JW, Sohn YJ, Jung HS, Won R, Sohn NK (2003) Alteration of neural activity and effect of Yanggyuksanhwa-tang(Lianggesanhuo-tang) on cerebral ischemia of aged BCAO rats; [14C]2-Deoxyglucose autoradiography study. J Korean Orient Med 24(3):51–64

    Google Scholar 

  • Son SK, Shin MG, Song IB (2001) Effects of Yanggyuksanhwa-Tang on cerebral blood flow and ischemic brain damage in rats. J Sasang Const Med 13(2):165–176

    Google Scholar 

  • Yun BH, Park SS (2004) Yangkyuksanhwa-tang effected to atopic dermatitis. J Sasang Const Med 16(2):84–98

    Google Scholar 

Download references

Acknowledgments

This work was supported by a grant from Kyung Hee University in 2013 (KHU-20131087)

Conflict of Interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Sasang Constitutional Medicine, College of Korean Med., Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, 130-702, South Korea

    Seung Won Shin, Euiju Lee, Byung-Hee Koh & Junhee Lee

  2. Department of Science in Korean Medicine, Cancer Preventive Material Development Research Center, College of Korean Med., Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, 130-702, South Korea

    Seok-Geun Lee

  3. College of Korean Med., Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, 130-702, South Korea

    Kwang Seok Ahn

  4. Department of Biochem. College of Korean Med., Kyung Hee University, 1 Heogi-dong, Dongdaemun-gu, Seoul, 130-702, South Korea

    Hyeung-Jin Jang

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  1. Seung Won Shin
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  2. Seok-Geun Lee
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  3. Hyeung-Jin Jang
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  4. Kwang Seok Ahn
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  5. Euiju Lee
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  6. Byung-Hee Koh
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  7. Junhee Lee
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Correspondence to Junhee Lee.

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Shin, S.W., Lee, SG., Jang, HJ. et al. Review of experimental and clinical studies on Soyangin (少陽人) Yanggyeoksanhwa-tang (凉膈散火湯) in Korea since 2000. Orient Pharm Exp Med 14, 291–300 (2014). https://doi.org/10.1007/s13596-014-0155-5

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  • DOI: https://doi.org/10.1007/s13596-014-0155-5

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