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Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine

  • Review Article
  • Published:
Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

Background:

Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains hindered by detrimental responses in the host against such vectors (immunogenic responses, vector dissemination to nontarget locations). Combining viral gene therapy techniques with tissue engineering procedures may offer strong tools to improve the current systems for applications in vivo.

Methods:

The goal of this work is to provide an overview of the most recent systems exploiting biomaterial technologies and therapeutic viral gene transfer in human orthopaedic regenerative medicine.

Results:

Integration of tissue engineering platforms with viral gene vectors is an active area of research in orthopaedics as a means to overcome the obstacles precluding effective viral gene therapy.

Conclusions:

In light of promising preclinical data that may rapidly expand in a close future, biomaterial-guided viral gene therapy has a strong potential for translation in the field of human orthopaedic regenerative medicine.

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Acknowledgement

This work was supported by a Grant from the Deutsche Forschungsgemeinschaft (DFG VE 1099/1-1 to JKV and MC).

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  1. Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr, Bldg 37, 66421, Homburg/Saar, Germany

    Jagadeesh Kumar Venkatesan, Ana Rey-Rico & Magali Cucchiarini

  2. Cell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, Campus de A Coruña, 15071, A Coruña, Spain

    Ana Rey-Rico

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  1. Jagadeesh Kumar Venkatesan
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Venkatesan, J.K., Rey-Rico, A. & Cucchiarini, M. Current Trends in Viral Gene Therapy for Human Orthopaedic Regenerative Medicine. Tissue Eng Regen Med 16, 345–355 (2019). https://doi.org/10.1007/s13770-019-00179-x

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