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Role of Reactive Oxygen Species in Cancer Progression

  • Chemical and Molecular Toxicology (J Bolton, Section Editor)
  • Published:
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Abstract

Purpose of Review

Although there are significant improvements in diagnosis and therapeutics tools, cancer remained a major cause of deaths in developing and developed countries. Among others, endogenously or exogenously generating reactive oxygen species (ROSs) are considered a crucial cause for tumor initiation, development, and survival. Unhealthy lifestyle, exposure to various carcinogens, ionizing radiations, and chemotherapy drugs are the main factors for ROS production.

Recent Findings

Reactive oxygen species cause genetic instability due to DNA damage or mutation load. Exposer to ROS also modulates the expression of various transcription factors such as Sp1, AP1, and NF-κβ implicated in proliferation, metastasis, and cancer stem cell maintenance. It is suggested that ROSs are involved in various cancer-related process including apoptosis, angiogenesis, metastasis, and inflammation. Numerous data from several studies suggest ROS as one of the therapeutic targets for cancer prevention and cure.

Summary

The current review summarizing the interactions of ROSs with various cellular molecules involved in angiogenesis, metastasis, and inflammation.

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Acknowledgments

Author would like to acknowledge Department of Histopathology, Postgraduate Institute of Medical Education (PGIMER), Chandigarh, India, and MMDU, Mullana, India, for supporting this study.

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Authors and Affiliations

  1. Department of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab, 160012, India

    Dharambir Kashyap

  2. Department of Biotechnology, M.M. (Deemed to be University), Mulana, Ambala, Haryana, India

    Hardeep Singh Tuli, Sandeep Punia & Ashun Chaudhary

  3. NGO, Praeventio, Tartu, Estonia

    Katrin Sak

  4. Department of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab, 160012, India

    Vivek Kumar Garg

  5. Department of Information Technology, University Institute of Engineering and Technology, Panjab University, Chandigarh, 160014, India

    Neelam Goel

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  1. Dharambir Kashyap
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Correspondence to Hardeep Singh Tuli.

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Kashyap, D., Tuli, H.S., Sak, K. et al. Role of Reactive Oxygen Species in Cancer Progression. Curr Pharmacol Rep 5, 79–86 (2019). https://doi.org/10.1007/s40495-019-00171-y

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