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Exploring Hydrogen Bond in Biological Molecules

  • Review Article
  • Published:
Journal of the Indian Institute of Science Aims and scope

Abstract

Life makes extensive use of non-covalent interactions, as they are a convenient way to build complex structures that can be assembled or disassembled quickly, with a minimum energy consumption. Among the inter-molecular interactions, hydrogen bond plays a central role, and it is the main responsible of the structure of proteins, DNA, and several other superstructures in the cell. Characterization of hydrogen bond in biologic environment is not an easy task, and several complex and imaginative techniques have been developed to circumvent the technical challenges of such studies. We present here an overview of the field of mass-resolved laser spectroscopy applied to nucleobases, peptides, and monosaccharides to demonstrate that despite the different environment the molecules encounter in the jet, such experiments yield important structural information that helps understanding the role played by hydrogen bond in biology.

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Figure 1:

Adapted from Ref.16.

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Adapted from Ref.24.

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Adapted from Ref. 28.

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Adapted from Ref. 141.

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Acknowledgements

This work has received funds from MINECO/FEDER (CTQ2015-68148-C2-1-P), MICIU(PGC2018-098561-B-C21) and Basque Government (IT1162-19). Most of the results presented in this work have been possible thanks to the support of the computing infrastructure of the i2BASQUE academic network and the SGI/IZO-SGIker network. I would like to thank the technical support from the personnel from the UPV/EHU laser facility.

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  1. Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Barrio Sarriena s/n, 48940, Leioa, Spain

    José A. Fernández

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Fernández, J.A. Exploring Hydrogen Bond in Biological Molecules. J Indian Inst Sci 100, 135–154 (2020). https://doi.org/10.1007/s41745-019-00146-4

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