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3D-Printed Scaffolds with Reinforced Poly (Lactic Acid)/Carbon Nanotube Filaments Based on Melt Extrusion

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Abstract

Personalized medicine suitable for individual patients in tissue engineering is a significant challenge. Owing to the recent growth of 3D printing, various methods of building objects have been proposed. However, there is very little information about the mechanical properties of the pieces obtained by controlling the process variables using composite filaments. Fused deposition modeling (FDM) technology was used to fabricate new scaffolds with infill patterns, interconnected channel networks, controllable porosity, and size. Polylactic acid (PLA)/carbon nanotube (CNT) filaments were synthesized using the melt extrusion technique. An improvement in the mechanical properties was observed in composites compared with the pure polymer. Moreover, no toxicity was expressed by stem cells after 24 h of incubation in the presence of composite filaments for a high CNT concentration. Our results will aid in the scaffold design of composite filaments through the modeling of process parameters and mechanical properties.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (No. 2018R1A6A1A03025582) and the National Research Foundation of Korea (NRF-2016R1D1 A3B03932921).

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Author notes

  1. Hye-Been Kim and Dinesh K. Patel contributed equally to this work.

Authors and Affiliations

  1. Department of Biosystems Engineering, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea

    Hye-Been Kim, Yu-Ri Seo & Ki-Taek Lim

  2. The Institute of Forest Science, Kangwon National University, Chuncheon, 24341, Republic of Korea

    Dinesh K. Patel & Ki-Taek Lim

Authors
  1. Hye-Been Kim
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  2. Dinesh K. Patel
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  3. Yu-Ri Seo
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Corresponding author

Correspondence to Ki-Taek Lim.

Ethics declarations

All protocols for human tissue processing were developed in accordance with the legal regulatory guidelines for human tissues and organs in the experimental protocol approved by the Seoul National University (Seoul, South Korea) Institutional Review Board (IRB No. CRI05008)

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The authors declare that they have no conflict of interest.

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Kim, HB., Patel, D.K., Seo, YR. et al. 3D-Printed Scaffolds with Reinforced Poly (Lactic Acid)/Carbon Nanotube Filaments Based on Melt Extrusion. J. Biosyst. Eng. 44, 120–127 (2019). https://doi.org/10.1007/s42853-019-00011-3

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  • DOI: https://doi.org/10.1007/s42853-019-00011-3

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