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Effects of retinoids on the generation of neutrophil-derived reactive oxygen species studied by EPR spin trapping techniques

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Abstract.

Objective: To study the potential efficacy of retinoids on granulocytes with regard to their role in inflammatory dermatoses.¶Methods: We investigated the in vitro effect of acitretin and isotretinoin on the generation of reactive oxygen species (ROS) by stimulated human neutrophils using EPR spin trapping techniques.¶Results: The effects of the two retinoids on ROS generation by neutrophils were different. Acitretin increased the generation of hydroxyl radicals, whereas isotretinoin showed an antioxidant activity against the superoxide anion.¶Conclusions: Our study demonstrates retinoid type-dependent effects on ROS production by stimulated neutrophils.

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Bohne, M., Struy, H., Gerber, A. et al. Effects of retinoids on the generation of neutrophil-derived reactive oxygen species studied by EPR spin trapping techniques. Inflamm. res. 46, 423–424 (1997). https://doi.org/10.1007/s000110050216

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  • DOI: https://doi.org/10.1007/s000110050216

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