Abstract
Necrosis has long been considered as a passive event resulting from a cell extrinsic stimulus, such as pathogen infection. Recent advances have refined this view and it is now well established that necrosis is tightly regulated at the cell level. Regulated necrosis can occur in the context of host–pathogen interactions, and can either participate in the control of infection or favor it. Here, we review the two main pathways implicated so far in bacteria-associated regulated necrosis: caspase 1-dependent pyroptosis and RIPK1/RIPK3-dependent necroptosis. We present how these pathways are modulated in the context of infection by a series of model bacterial pathogens.
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Acknowledgments
We apologize to the many colleagues whose work has not been discussed. We thank the members of the Biology of Infection Unit for helpful discussions. Research in the Biology of Infection Unit is supported by Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Agence Nationale de la Recherche, LabEx IBEID, the Proantilis EU program and the European Research Council.
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Blériot, C., Lecuit, M. The interplay between regulated necrosis and bacterial infection. Cell. Mol. Life Sci. 73, 2369–2378 (2016). https://doi.org/10.1007/s00018-016-2206-1
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DOI: https://doi.org/10.1007/s00018-016-2206-1