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Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii)

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Abstract

Devil facial tumour disease (DFTD) comprises two genetically distinct transmissible cancers (DFT1 and DFT2) endangering the survival of the Tasmanian devil (Sarcophilus harrisii) in the wild. DFT1 first arose from a cell of the Schwann cell lineage; however, the tissue-of-origin of the recently discovered DFT2 cancer is unknown. In this study, we compared the transcriptome and proteome of DFT2 tumours to DFT1 and normal Tasmanian devil tissues to determine the tissue-of-origin of the DFT2 cancer. Our findings demonstrate that DFT2 expresses a range of Schwann cell markers and exhibits expression patterns consistent with a similar origin to the DFT1 cancer. Furthermore, DFT2 cells express genes associated with the repair response to peripheral nerve damage. These findings suggest that devils may be predisposed to transmissible cancers of Schwann cell origin. The combined effect of factors such as frequent nerve damage from biting, Schwann cell plasticity and low genetic diversity may allow these cancers to develop on rare occasions. The emergence of two independent transmissible cancers from the same tissue in the Tasmanian devil presents an unprecedented opportunity to gain insight into cancer development, evolution and immune evasion in mammalian species.

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Acknowledgements

The authors wish to thank Narelle Phillips for immunohistochemistry and Anne-Maree Pearse and Kate Swift of the DPIPWE for provision of the DFT1 cell line used in this manuscript. We also thank the Walter and Eliza Hall Institute for Medical Research computational biology division for their bioinformatics expertise and assistance, and Maximilian Stammnitz and Young Mi Kwon for useful discussion. Aspects of this research were conducted at the Australian Proteome Analysis Facility (APAF) under the Australian Government’s National Collaborative Research Infrastructure Scheme. Research support was provided by the Australian Research Council (DP180100520), the University of Tasmania Foundation through funds raised by the Save the Tasmanian Devil Appeal and a joint research initiative between the University of Tasmania and Bioplatforms Australia.

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Authors and Affiliations

  1. Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart, TAS, 7000, Australia

    Amanda L. Patchett, Jocelyn Darby, Ruth J. Pye, Andrew S. Flies, Gregory M. Woods & Cesar Tovar

  2. Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK

    Tim H. H. Coorens & Elizabeth P. Murchison

  3. Central Science Laboratory, University of Tasmania, Hobart, TAS, 7001, Australia

    Richard Wilson

  4. Australian Proteome Analysis Facility, Department of Molecular Sciences, Macquarie University, Sydney, NSW, 2109, Australia

    Matthew J. McKay & Karthik S. Kamath

  5. Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, 3000, Australia

    Alan Rubin, Matthew Wakefield, Lachlan Mcintosh, Stefano Mangiola, Lynn M. Corcoran & Anthony T. Papenfuss

  6. Department of Medical Biology, The University of Melbourne, Melbourne, VIC, 3000, Australia

    Alan Rubin, Matthew Wakefield, Lynn M. Corcoran & Anthony T. Papenfuss

  7. Department of Mathematics and Statistics, The University of Melbourne, Melbourne, VIC, 3000, Australia

    Lachlan Mcintosh

  8. Department of Surgery, The University of Melbourne, Melbourne, VIC, 3000, Australia

    Stefano Mangiola

  9. School of Medicine, University of Tasmania, Hobart, TAS, 7000, Australia

    A. Bruce Lyons

  10. Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia

    Anthony T. Papenfuss

  11. Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, 3000, Australia

    Anthony T. Papenfuss

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  1. Amanda L. Patchett
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Patchett, A.L., Coorens, T.H.H., Darby, J. et al. Two of a kind: transmissible Schwann cell cancers in the endangered Tasmanian devil (Sarcophilus harrisii). Cell. Mol. Life Sci. 77, 1847–1858 (2020). https://doi.org/10.1007/s00018-019-03259-2

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