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Cardiovascular disease in patients with chronic kidney disease

Kardiovaskuläre Erkrankungen bei Patienten mit chronischer Niereninsuffizienz

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Abstract

Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therapeutic challenges of heart failure, coronary artery disease, and atrial fibrillation.

Zusammenfassung

Patienten mit chronischer Nierenerkrankung („chronic kidney disease“, CKD) weisen ein erhöhtes Risiko für Nierenversagen, Herz-Kreislauf-Erkrankungen („cardiovascular disease“, CVD) und Tod auf. Die Wahrscheinlichkeit, durch eine CVD zu sterben, ist höher als die Wahrscheinlichkeit, aufgrund terminaler Niereninsuffizienz dialysepflichtig zu werden. Evidenzbasierte Therapien von Komorbiditäten wie CVD bleiben bei Patienten mit fortgeschrittener CKD eine Herausforderung, da diese Patienten üblicherweise aus randomisierten kontrollierten Studien ausgeschlossen werden. Diese Übersichtsarbeit fokussiert auf die Epidemiologie, Risikofaktoren und klinischen Manifestationen von CVD bei Patienten mit fortgeschrittener CKD. Speziell hervorgehobene Themen sind die diagnostischen und therapeutischen Herausforderungen bei Herzinsuffizienz, koronarer Herzkrankheit und Vorhofflimmern.

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  1. Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Germany

    Turgay Saritas & Jürgen Floege

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  1. Turgay Saritas
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  2. Jürgen Floege
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Correspondence to Turgay Saritas.

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T. Saritas and J. Floege declare that they have no competing interests.

For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.

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Saritas, T., Floege, J. Cardiovascular disease in patients with chronic kidney disease. Herz 45, 122–128 (2020). https://doi.org/10.1007/s00059-019-04884-0

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