Abstract
The acute, lethal potency of the 1,2,3,4-, 1,2,4,5- and 1,2,3,5-tetrachlorobenzene isomers was compared in the terrestrial and aquatic oligochaetes Eisenia andrei and Tubifex tubifex. 1,2,4,5-TeCB was neither lethal, nor produced any perceptible adverse effects, at lipid normalized concentrations predicted to be lethal according to the well-established critical body residue concept. If a narcotic is defined as a substance capable of inducing narcosis, rather than a substance displaying certain physical or chemical properties (e.g., log Kow), then we do not believe these findings challenge the critical body residue because by the former definition, 1,2,4,5-tetrachlorobenzene is not a narcotic.
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Hurdzan, C.M., Lanno, R.P. & Sovic, D.M. Differential Acute Toxicity of Tetrachlorobenzene Isomers to Oligochaetes in Soil and Water: Application of the Critical Body Residue Concept. Bull Environ Contam Toxicol 87, 209–214 (2011). https://doi.org/10.1007/s00128-011-0329-5
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DOI: https://doi.org/10.1007/s00128-011-0329-5