Skip to main content
Log in

Deltamethrin Induced Toxicity and Ameliorative Effect of Alpha-Tocopherol in Broilers

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

Abstract

Deltamethrin (DM) is a broad-spectrum insecticide mainly used to protect crops, fruit and vegetables from pests such as mites, ants, weevils and beetles. Birds, animals and human beings living in same ecosystem are directly or indirectly at the risk of exposure to this insecticide leading to substantial decrease in growth. Thus we studied DM induced toxicity and ameliorative effects of alpha-tocopherol in broiler birds. DM was estimated in liver, breast and leg muscles of chickens feeding with only DM or DM with alpha-tocopherol daily for 42 days. Birds exposed to DM showed a dose dependent decrease in body weight on 5th, 6th and 7th weeks as compared to controls, and alpha-tocopherol partially restored the reduction in body weight. DM residue was found higher in liver as compared to breast and leg muscles.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Akhtar MH, Hamilton RMG, Trenholm HL (1985) Metabolism, distribution, and excretion of deltamethrin by Leghorn hens. J Agric Food Chem 33:610–617

    Article  CAS  Google Scholar 

  • Akhtar MH, Danis C, Trenholm HL (1992) Deltamethrin residues in milk and tissues of lactating dairy cows. J Environ Sci Health B 2:235–253

    Google Scholar 

  • Boren B, Bond P (1996) Vitamin E and immunocompetence. Broiler Indus 11:26–33

    Google Scholar 

  • Chew BP (1995) Antioxidant vitamin affects food animal immunity and health. J Nutr 8(130):1910–1913

    Google Scholar 

  • El-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH (2004) Role of ∝-tochopherol and β-carotene in ameliorating the fenvalerate-induced changes in oxidative stress, hemato-biochemical parameters and semen quality of male rats. J Environ Sci Health B 39:443–459

    CAS  Google Scholar 

  • Gabbianelli R, Nasuti C, Falcioni G, Cantalamess F (2004) Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C. Toxicology 203:17–26

    Article  CAS  Google Scholar 

  • Giray B, Gurbay A, Hincal F (2001) Cypermethrin-induced oxidative stress in rat brain and liver is prevented by Vitamin E and allopurinol. Toxicol Lett 118:139–140

    Article  CAS  Google Scholar 

  • Hardman JG, Limbird LE, Hardman L, Goodman, Gilman S (2001). The pharmacological basis of therapeutics, 9th edn. Publ Mc Graw-Hill Health Professions Division 1651–1669

  • Hutson D, Stoydin G (1987) Excretion and residues of the pyrethroid insecticide cypermethrin in laying hens. Pestic Sci 18:157–168

    Article  CAS  Google Scholar 

  • Jayasree U, Gopala Reddy A, Reddy KS, Kalakumar B (2003) A study on the mechanism of toxicity of deltamethrin in poultry. Toxicol Int 10(2):111–114

    CAS  Google Scholar 

  • Johnson M, Luukinen B, Buhl K, Stone D (2010) Deltamethrin technical fact sheet; National Pesticide Information Center, Oregon State University Extension Services. http://npic.orst.edu/factsheets/Deltatech.pdf

  • Kale M, Rathore N, Jone S, Bhatnagar D (1999) Lipid peroxidative damage on pyrethroid exposure and alterations in antioxidant status in rat erythrocytes: a possible involvement of reactive oxygen species. Toxicol Lett 105:197–205

    Article  CAS  Google Scholar 

  • Leake LD, Buckley DS, Ford MG, Salt DW (1985) Comparative effects of pyrethroids on neurones of target and non-target organisms. Neurotoxicology 6(2):99–116

    CAS  Google Scholar 

  • Lu FC, Kacew S (2009) Lu’s basic toxicology: fundamentals, target organs and risk assessment, 5th edn. Informa Healthcare USA, NewYork

    Book  Google Scholar 

  • Maghraby El (2007) Metabolism of deltamethrin in rats. Biomed Environ Sci 20:212–216

    Google Scholar 

  • Mardones P, Rigotti A (2008) Cellular mechanisms of vitamin E uptake: relevance in α-tocopherol metabolism and potential implications for disease. J Nutr Biochem 15:252–260

    Article  Google Scholar 

  • Marie AE, Ruzo LO, Casida JE (1982) Analysis and persistence of permethrin, cypermethrin, deltamethrin and fenvalerate in the fat and brain of treated rats. J Agric Food Chem 30:558–562

    Article  Google Scholar 

  • Mishra S, Sharma LD, Ahmad AH (1996) Experimental deltamethrin toxicity in poultry. Indian J Vet Med 16(1):40–45

    Google Scholar 

  • Mohapatra M, Mallick PN (1998) Effect of deltamethrin on broilers. Recent advances in toxicology. XVII Annual Conference of Society of Toxicology, India, pp.41

  • Muccio AD, Pelosi P, Barbini DA (1997) Selective extraction of pyrethroid pesticide residues from milk by solid-matrix dispersion. J Chromatogr A 765:51–60

    Article  Google Scholar 

  • OECD (1981) Guideline for the testing of chemicals 411 subchronic dermal toxicity: a 90-day study. Organisation for Economic Cooperation and Development, Paris

    Book  Google Scholar 

  • Pattison MP, Mc Mullin PF, Bradbury JM, Alexander DJ (2008) Toxicant in poultry. Poultry diseases, 6th edn. Saunders Elsevier, Philadelphia, pp 553–554

    Google Scholar 

  • Ray DE, Fry JRA (2006) A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol Ther 111(1):174–193

    Article  CAS  Google Scholar 

  • Sondhia S (2008) Determination of imazosulfuron persistence in rice crop and soil. Environ Monit Assess 137:205–211

    Article  CAS  Google Scholar 

  • Sondhia S, Dubey RP (2006) Determination of terminal residues of butachlor and pendimethalin in onion. Pestic Res J 18:85–86

    CAS  Google Scholar 

  • Sondhia S, Singhai B (2008) Persistence of sulfosulfuron under wheat cropping system. Bull Environ Cont Toxicol 80(5):423–427

    Article  CAS  Google Scholar 

  • Tomlin CDS (2006) The pesticide manual: a world compendium, 14th edn. British Crop Protection Council, Farnham, pp 286–287

    Google Scholar 

  • Vegad JL (2008) Poultry diseases a guide for farmers and poultry professionals, II edn. International Book Distribution Co, Lucknow, p 461

    Google Scholar 

  • Walden BV De G (1982) Deltamethrin, monograph. Russel—Uclaf. France

  • Wollen BH (1993) Biological monitoring for pesticide absorption. Ann Occup Hyg 37:525–540

    Article  Google Scholar 

  • Wollen BH, Marsh JR, Laird WJD (1992) The metabolism of cypermethrin in man: differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 22:983–991

    Article  Google Scholar 

  • Yarkov D (2006) Long term exposure of live poultry to alphacypermethrin and its residue levels in poultry meat. Trakia J Sci 4(3):34–36

    Google Scholar 

  • Yousef MI, Abdallah GA, Kamel KI (2003) Effect of ascorbic acid and Vitamin E supplementation on semen quality and biochemical parameters of male rabbit. Anim Reprod Sci 76:99–111

    Article  CAS  Google Scholar 

  • Yousef MI, Awad TI, Mohamed EH (2006) Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Vitamin E. Toxicology 227(3):240–247

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shobha Sondhia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chandra, N., Jain, N.K., Sondhia, S. et al. Deltamethrin Induced Toxicity and Ameliorative Effect of Alpha-Tocopherol in Broilers. Bull Environ Contam Toxicol 90, 673–678 (2013). https://doi.org/10.1007/s00128-013-0981-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00128-013-0981-z

Keywords

Navigation