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Coupled plasma filtration adsorption

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Abstract

Background

Severe sepsis and septic shock are perhaps the major cause of morbidity and mortality in Intensive Care. Their pathogenesis is only partly understood. Circulating peptides and lipid-derived substances (so-called mediators), however, appear to participate in the development of organ dysfunction. It might be possible to treat plasma in such a way that the injurious effect of mediators can be attenuated.

Investigations

Several ex vivo studies have shown that it is technically possible to adsorb mediators by means of specially developed sorbents. The application of these sorbents to the treatment of plasma in animals with experimental sepsis has shown that several markers of inflammation can be attenuated and that animal survival can be increased. We have recently transferred such technology to the treatment of human septic shock using a technique called Coupled Plasma Filtration Adsorption (CPFA). CPFA was found to attenuate the hypotension of septic shock and to dramatically alter the immuno-paralytic toxicity of septic plasma. Monocytes of patients treated with CPFA underwent a major improvement in their ability to respond to endotoxin.

Conclusions

CPFA represents a promising new approach to blood purification in sepsis. The findings associated with its application to humans highlight the importance of continuing to investigate blood purification as a possible approach to the treatment of septic shock, the potential usefulness of the humoral theory of sepsis, and the dominant state of immunosuppression associated with established septic shock.

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Author information

Authors and Affiliations

  1. Department of Intensive Care, Austin & Repatriation Medical Centre, Studley Rd, 3084, Heidelberg, Victoria, Melbourne, Australia

    Rinaldo Bellomo

  2. Clinical and Laboratory Research Department at Bellco, Bellco, Mirandola, Italy

    Ciro Tetta

  3. Department of Nephrology, St Bortolo Hospital, Vicenza, Italy

    Claudio Ronco

Authors
  1. Rinaldo Bellomo
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  2. Ciro Tetta
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  3. Claudio Ronco
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Corresponding author

Correspondence to Rinaldo Bellomo.

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Bellomo, R., Tetta, C. & Ronco, C. Coupled plasma filtration adsorption. Intensive Care Med 29, 1222–1228 (2003). https://doi.org/10.1007/s00134-003-1796-x

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