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Monocyte distribution width as a biomarker of resistance to corticosteroids in patients with sepsis: the MOCORSEP observational study

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Fig. 1

Data availability

The complete deidentified patient data set will be shared with researchers whose proposed use of the data has been approved and will be made available with the publication of the manuscript. Proposals should be submitted to DA (djillali.annane@aphp.fr); to gain access, data requestors will need to sign a data access agreement.

Code availability

Code for statistical analysis plan will be shared with researchers whose proposed use of the data has been approved and will be made available with publication of the manuscript. Requests should be submitted to Prof. Sylvie Chevret (sylvie.chevret@u-paris.fr).

References

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Acknowledgements

The members of the MOCORSEP Study Group are: Djillali Annane, MD: Department of Intensive Care Hôpital Raymond Poincaré (APHP), Garches, France, Laboratory of Infection and Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University Paris Saclay, INSERM, Montigny-Le-Bretonneau, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France; Martin Rottman, MD: Laboratory of Infection and Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University Paris Saclay, INSERM, Montigny-Le-Bretonneau, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France, Innovative Biomarkers Platform, Hôpital Raymond Poincaré (APHP), Garches, France; Nicholas Heming, MD: Department of Intensive Care Hôpital Raymond Poincaré (APHP), Garches, France, Laboratory of Infection and Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University Paris Saclay, INSERM, Montigny-Le-Bretonneau, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France; Véronique Godot, PhD: Vaccine Research Institute, Créteil, France, Inserm U955, Equipe 16, Créteil, France, University Paris-Est Créteil, Créteil, France; Jérôme Fleuriet, PhD: Department of Intensive Care Hôpital Raymond Poincaré (APHP), Garches, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France; Jean Sébastien Blanchet, PhD: Medical and Scientific Affairs Beckman Coulter, Villepinte, France; Pierre Moine, MD: Department of Intensive Care Hôpital Raymond Poincaré (APHP), Garches, France, Laboratory of Infection and Inflammation _ U1173, School of Medicine Simone Veil, University Versailles Saint Quentin _ University Paris Saclay, INSERM, Montigny-Le-Bretonneau, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France; Lamiae Grimaldi, PharmD: FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis), Garches, France, Clinical Research Unit APHP Paris-Saclay, University Paris-Saclay, UVSQ, Inserm, Anti-infective evasion and pharmacoepidemiology, CESP, Montigny le Bretonneux, France; Sylvie Chevret, MD: Department of Biostatistics, hôpital Saint Louis (APHP), ECSTRRA Team, UMR1153, INSERM, Université de Paris. Collaborators include RHU RECORDS consortium and the FHU SEPSIS (Saclay and Paris Seine Nord Endeavour for Personalized Interventions for Sepsis). RECORDS collaborators: Annane Djillali, M.D., Ph.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Laboratory of Infection and Inflammation Unité 1173, Université Paris-Saclay, UVSQ, INSERM, Montigny-le-Bretonneux, France. Moine Pierre, M.D., Ph.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Heming Nicholas, M.D., Ph.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Maxime Virginie, M.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Clair Bernard, M.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Orlikowski David, M.D., Ph.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Bouneb Rania, M.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France ; Murg Eleonora, M.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Abdeladim Lilia, M.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Fayssoil Abdallah, M.D., Ph.D., Service de Médecine Intensive et Réanimation, Hôpital Raymond Poincaré, Garches, France; Blanchet Jean-Sébastien, Ph.D., Beckman Coulter France, Villepinte, France. Chevret Sylvie, M.D., Ph.D., Service de Biostatistique, Hôpital Saint-Louis (AP-HP), Université de Paris, INSERM UMR1153, France. Daniel Christel, M.D., Ph.D., AP-HP Information Systems Direction, Paris, France; Sorbonne University, University Paris 13, Sorbonne Paris Cité, INSERM UMR S 1142, LIMICS, Paris, France. Devillier Philippe, M.D., Ph.D., Laboratoire de Pharmacologie Respiratoire, V2I - UMR-0092, Université Paris-Saclay, UVSQ, Suresnes, France; Hôpital Foch, Exhalomics®, Département des maladies des voies respiratoires, Suresnes, France. Fleuriet Jérome, Ph.D., APHP, Hôpital Raymond Poincaré, Garches, France. François Bruno, M.D., Réanimation Polyvalente, INSERM Centre d'Investigation Clinique (CIC) 1435, Centre Hospitalier Universitaire (CHU) Dupuytren, INSERM Unité Mixte de Recherche (UMR) 1092, Faculté de Médecine, Université de Limoges, France. Garchon Henri-Jean, Ph.D., Université Paris-Saclay, UVSQ, Inserm, UMR 1173, Infection et inflammation, 78180, Montigny-Le-Bretonneux, France; INFLAMEX, Laboratoire d’Excellence, Université Paris, France; Genetics division, Hôpital Ambroise Paré, AP-HP, 9 avenue Charles de Gaulle, 92100 Boulogne-Billancourt, France. Godot Véronique, Ph.D., Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Equipe 16, Créteil 94000, France; Faculté de médecine, Université Paris Est, Créteil 94000, France; Vaccine Research Institute (VRI), Créteil 94000, France. Grassin-Delyle Stanislas, PharmD., Ph.D., Université Paris-Saclay, UVSQ, INSERM, UMR1173, Infection et Inflammation, 78180, Montigny-Le-Bretonneux, France; Hôpital Foch, Exhalomics®, Département des maladies des voies respiratoires, Suresnes, France. Grimaldi Lamiae, PharmD., Ph.D., Clinical Research Unit AP-HP Paris-Saclay, School of Medicine Simone Veil, University Versailles Saint Quentin – University Paris Saclay, INSERM, CESP Anti-Infective Evasion and Pharmacoepidemiology Team, F-78180, Montigny-Le-Bretonneux, France. Kedad Zoubida, Ph.D., Université Paris-Saclay, UVSQ, Données et Algorithmes pour une ville intelligente et durable, 78035, Versailles, France. Lassalle Philippe, Ph.D., INSERM U1019E13, Campus Pasteur Lille, 1 rue du Professeur Calmette, 59000, Lille. Richly Maximilian U, Ph.D., Lumedix SAS, Paris, France. Rottman Martin, M.D., Ph.D., Université Paris-Saclay, UVSQ , UMR 1173, UFR Simone Veil, Montigny-le-Bretonneux, France; Laboratoire de Microbiologie, Hôpital Raymond Poincaré (AP-HP), Garches, France. Roux Anne-Laure, M.D., Laboratoire de Microbiologie, Hôpital Ambroise Paré (AP-HP), Boulogne-Billancourt, France; UMR1173, UFR Simone Veil, Université Paris-Saclay, UVSQ, Montigny-le-Bretonneux, France. Talini Luc, Ph.D., Easy Life Science, Paris, France. - Zeitouni Karine, Ph.D., Université Paris-Saclay, UVSQ, Données et Algorithmes pour une ville intelligente et durable, 78035, Versailles, France. FHU Collaborators: Djillali Annane, Chef du service Réanimation médicale adulte, Hôpital Raymond-Poincaré. Valérie Bardet, Chef du service Hématologie-Immunologie, Hôpital Ambroise-Paré. Xavier Monnet, Service de Médecine intensive Réanimation, Hôpital Bicêtre. Lamiae Grimaldi, Responsable des Unités de Recherche Clinique AP-HP Paris Saclay. Sylvie Chevret, Chef du service de Biostatistique et information médicale, Hôpital Saint-Louis. Anne-Laure Roux, Service de Microbiologie et Hygiène, Hôpital Ambroise-Paré. Martin Rottman, Service de Microbiologie et Hygiène, Hôpital Raymond-Poincaré. Stanislas Grassin-Delyle, UVSQ/Inserm/Département des Maladies respiratoires, Hôpital Foch. Henri-Jean Garchon, UVSQ/Inserm. Xavier Monnet, Service de Médecine intensive Réanimation, Hôpital Bicêtre. Antoine Vieillard-Baron, Chef du Service Médecine intensive Réanimation, Hôpital Ambroise-Paré. Guillaume Géri, Service de Médecine Intensive Réanimation, Hôpital Ambroise-Paré. Ziad Massy, Chef du service Néphrologie, Hôpital Ambroise-Paré. Jean-Claude Alvarez, Chef du service Pharmacologie-Toxicologie, Hôpital Raymond-Poincaré. Marie Essig, Service Néphrologie, Hôpital Ambroise-Paré. Amine Larabi, Service Pharmacologie-Toxicologie, Hôpital Raymond-Poincaré. Valérie Bardet, Chef du service Hématologie-Immunologie, Hôpital Ambroise-Paré. Bruno Mégarbane, Chef du service Réanimation médicale et toxicologique, Hôpital Lariboisière. Nicholas Heming, Service Réanimation médicale adulte, Hôpital Raymond-Poincaré. Pierre Tissières, Chef du service Réanimation pédiatrique et Médecine néonatale, Hôpital Bicêtre. François Fay, Faculté de Pharmacie, Université Paris Saclay. Marie-Anne Rameix-Welti, Service de Microbiologie-Hygiène, Hôpital Ambroise Paré. Bruno Mégarbane, Chef du service Réanimation médicale et toxicologique, Hôpital Lariboisière. Pierre Moine, Service Réanimation médicale adulte, Hôpital Raymond-Poincaré. Karine Zeitouni, DAVID, UVSQ. Laurent Dumas, LMV, UVSQ. Zaineb Chelly, DAVID, UVSQ. Martin Rottman, Service de Microbiologie et Hygiène, Hôpital Raymond-Poincaré. Anne-Laure Roux, Service de Microbiologie et Hygiène, Hôpital Ambroise-Paré. Loïc Josseran, Chef du service Épidémiologie santé publique, Hôpital Raymond-Poincaré. Mahmoud Zureik, Directeur d’EPI-PHARE (ANSM-CNAM).

Funding

The study has received a public grant through the national program “programme d’Investissements d’avenir” under the reference ANR-18-RHUS-0004. This work is part of Federations Hospitalo-universitaires (FHU) Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis (SEPSIS). Beckmann and Coulter provided the DxH 900 analyzer and the reagents for the duration of the study.

Author information

Authors and Affiliations

    Consortia

    For The MOCORSEP Study Group

    • Djillali Annane
    • , Martin Rottman
    • , Nicholas Heming
    • , Véronique Godot
    • , Jérôme Fleuriet
    • , Jean Sébastien Blanchet
    • , Pierre Moine
    • , Lamiae Grimaldi
    • , Sylvie Chevret

    • RHU RECORDS consortium

      • Annane Djillali
      • , Moine Pierre
      • , Heming Nicholas
      • , Maxime Virginie
      • , Clair Bernard
      • , Orlikowski David
      • , Bouneb Rania
      • , Murg Eleonora
      • , Abdeladim Lilia
      • , Fayssoil Abdallah
      • , Blanchet Jean-Sébastien
      • , Chevret Sylvie
      • , Daniel Christel
      • , Devillier Philippe
      • , Fleuriet Jérome
      • , François Bruno
      • , Garchon Henri-Jean
      • , Godot Véronique
      • , Grassin-Delyle Stanislas
      • , Grimaldi Lamiae
      • , Kedad Zoubida
      • , Lassalle Philippe
      • , U. Richly Maximilian
      • , Rottman Martin
      • , Roux Anne-Laure
      • , Talini Luc
      •  & Zeitouni Karine

    • the FHU SEPSIS (Saclay and Paris Seine Nord Endeavour for Personalized Interventions for Sepsis)

      • Djillali Annane
      • , Valérie Bardet
      • , Xavier Monnet
      • , Lamiae Grimaldi
      • , Sylvie Chevret
      • , Anne-Laure Roux
      • , Martin Rottman
      • , Stanislas Grassin-Delyle
      • , Henri-Jean Garchon
      • , Xavier Monnet
      • , Antoine Vieillard-Baron
      • , Guillaume Géri
      • , Ziad Massy
      • , Jean-Claude Alvarez
      • , Marie Essig
      • , Amine Larabi
      • , Valérie Bardet
      • , Bruno Mégarbane
      • , Nicholas Heming
      • , Pierre Tissières
      • , François Fay
      • , Marie-Anne Rameix-Welti
      • , Bruno Mégarbane
      • , Pierre Moine
      • , Karine Zeitouni
      • , Laurent Dumas
      • , Zaineb Chelly
      • , Martin Rottman
      • , Anne-Laure Roux
      • , Loïc Josseran
      •  & Mahmoud Zureik

    Contributions

    The senior author (DA) and the statistician (SC) prepared the initial manuscript draft. All authors participated in the acquisition, analysis, or interpretation of data for the work, provided a critical review of the manuscript, and were responsible for final approval to submit for publication.

    Ethics declarations

    Conflicts of interest

    DA received grants from Programme d’Investissements d’Avenir during the conduct of the study (ANR-18-RHUS-0004). MR, none. NH received grants from the French Ministry of Health “Programme Hospitalier de Recherche Clinique (PHRC-19-0173)”. VG, none. JF, none. JSB is employee of Beckman Coulter, has stock option from Danaher. PM has received consultant fees from Pfizer and from Proverpharm. LG, none. SC, none.

    Ethical approval

    The study protocol was approved by the Ethics Committee of the French Intensive Care Society, and by the Commission Nationale de l’Informatique et des Libertés (CNIL), with a waiver of consent. Opt-out options were proposed to patients.

    Consent to participate

    Written informed consent was waived by the Ethics committee. Opt-out options were proposed to patients.

    Consent to publish

    Patients were informed that their deidentified data will be pooled with data from other participants for publication in a peer-review journal.

    Additional information

    Publisher's Note

    Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

    The members of The MOCORSEP Study Group, FHU SEPSIS and RECORDS collaborators are listed in Acknowledgements section.

    Supplementary Information

    Below is the link to the electronic supplementary material.

    Supplementary file1 (DOCX 4209 kb)

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    For The MOCORSEP Study Group. Monocyte distribution width as a biomarker of resistance to corticosteroids in patients with sepsis: the MOCORSEP observational study. Intensive Care Med 47, 1161–1164 (2021). https://doi.org/10.1007/s00134-021-06478-z

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    • DOI: https://doi.org/10.1007/s00134-021-06478-z

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