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Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail

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Abstract

Introduction and hypothesis

Dimethyl sulfoxide (DMSO) bladder instillation is a standard therapy for interstitial cystitis (IC); however, there are varying degrees of success. We hypothesize that first-line intravesical therapy with a DMSO cocktail will optimize treatment outcome.

Methods

Ninety women with newly diagnosed IC were enrolled consecutively for the treatment. The IC symptom and problem index was used as an outcome measure.

Results

Six (6.7%) patients dropped out of the treatment due to intolerable bladder irritation. Fifty-five (65.5%) of the remaining 84 patients, who completed the treatment, experienced ≧50% symptomatic improvement. After a regression analysis, three clinical variables were found to affect treatment adversely, i.e., the presence of advanced cystoscopic glomerulations, microscopic hematuria, and urodynamic detrusor underactivity, respectively.

Conclusions

Our results suggest bladder instillation with a DMSO cocktail may well be considered as first-line therapy for IC patients. However, there exists a subgroup of nonresponders who may have severe disease.

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Abbreviations

DMSO:

Dimethylsulfoxide

IC:

Interstitial cystitis

NIDDK:

The National Institute of Diabetes, Digestive and Kidney Diseases

ICDB:

Interstitial cystitis data base

PBS:

Painful bladder syndrome

BPS:

Bladder pain syndrome

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Road, Taichung, 40705, Taiwan

    Man-Jung Hung, Yi-Ting Chen, Shih-Tien Hsu & Esther Shih-Chu Ho

  2. Department of Statistics, Tung Hai University, Taichung, Taiwan

    Pao-Sheng Shen

  3. Department of Obstetrics and Gynecology, Chung Shan Medical University School of Medicine, Taichung, Taiwan

    Man-Jung Hung, Gin-Den Chen & Esther Shih-Chu Ho

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  1. Man-Jung Hung
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  2. Yi-Ting Chen
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  3. Pao-Sheng Shen
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  4. Shih-Tien Hsu
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  5. Gin-Den Chen
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  6. Esther Shih-Chu Ho
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Correspondence to Man-Jung Hung.

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Hung, MJ., Chen, YT., Shen, PS. et al. Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail. Int Urogynecol J 23, 1533–1539 (2012). https://doi.org/10.1007/s00192-012-1699-x

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  • DOI: https://doi.org/10.1007/s00192-012-1699-x

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