Abstract
We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the “Enhanced OECD Test Guideline 407” to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group.
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This work was supported by a grant from Ministry of Economical Trade and Industry.
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Miyata, K., Shiraishi, K., Houshuyama, S. et al. Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the “Enhanced OECD Test Guideline no. 407”. Arch Toxicol 80, 181–186 (2006). https://doi.org/10.1007/s00204-005-0030-8
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DOI: https://doi.org/10.1007/s00204-005-0030-8