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Differential effects of estrogen and testosterone on auditory sensory gating in rats

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Abstract

Rationale

Estrogen has been shown to have beneficial effects in patients with schizophrenia. However, the mechanisms involved in this protective effect are unclear. Schizophrenia is associated with deficits in sensory gating, a filtering mechanism which normally prevents sensory overload. In rodent models, acute treatment with drugs such as the dopamine D1/D2 receptor agonist, apomorphine; the dopamine releaser, amphetamine; and the glutamate NMDA receptor antagonists, phencyclidine or MK-801, can induce a phenotype similar to that seen in schizophrenia.

Objectives

Given the putative protective action of estrogen in schizophrenia, here we investigated the effect of ovariectomy (OVX) and estrogen replacement in female rats on drug-induced auditory gating deficits. For comparison, we also assessed the effects of castration (CAST) and dihydrotestosterone (DHT) replacement in male rats.

Methods

Rats were instrumented with cortical surface electrodes. Test sessions comprised of 150 presentations of paired clicks, 500 ms apart (S1 and S2).

Results

Administration of all drugs increased the ratio of responses to S2/S1 in sham-operated female and male rats. OVX reduced event-related potential amplitudes but did not alter S2/S1 ratio or drug effects. In OVX rats with 17β-estradiol implants, the effect of apomorphine was abolished, but there was no change in that of amphetamine and phencyclidine. There were no effects of CAST or DHT replacement in male rats.

Conclusions

Chronic estrogen replacement in OVX rats protected against sensory gating deficits caused by direct dopamine D1/D2 receptor stimulation. These data could indicate a possible mechanism by which estrogen exerts a protective action in schizophrenia.

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Authors and Affiliations

  1. Behavioural Neuroscience Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia

    Shane J. Thwaites, Maarten van den Buuse & Andrea Gogos

  2. Department of Pharmacology, University of Melbourne, Melbourne, Australia

    Shane J. Thwaites & Maarten van den Buuse

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  1. Shane J. Thwaites
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  2. Maarten van den Buuse
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  3. Andrea Gogos
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Correspondence to Maarten van den Buuse.

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All experiments were performed within Australia and comply with current laws.

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Thwaites, S.J., van den Buuse, M. & Gogos, A. Differential effects of estrogen and testosterone on auditory sensory gating in rats. Psychopharmacology 231, 243–256 (2014). https://doi.org/10.1007/s00213-013-3231-5

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  • DOI: https://doi.org/10.1007/s00213-013-3231-5

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