Abstract
A flow injection method is proposed for the determination of naftopidil based upon the oxidation by potassium permanganate in a sulfuric acid medium and sensitized by formaldehyde and formic acid. The optimum chemical conditions for the chemiluminescence emission were 0.25 mM potassium permanganate and 4.0 M sulfuric acid. Two manifolds were tested and instrumental parameters such as the length of the reactor, injection volume and flow rate were compared. When using the selected manifold in the presence of 0.4 M formaldehyde, naftopidil gives a second-order calibration graph over the concentration range 0.1–40.0 mg L−1 with a detection limit calculated (as proposed by IUPAC) of 92.5 ng mL−1 and a standard deviation of 0.12 mg mL−1 for ten samples of 10.0 mg L−1 naftopidil. In the presence of 1.15 M formic acid, naftopidil gives a second-order calibration graph over the concentration range 0.05–40.0 mg L−1 with a detection limit of 14.2 ng mL−1 and a standard deviation of 0.37 mg mL−1 for ten samples of 10.0 mg L−1 naftopidil. In both cases, the determination is free from interferences from common excipients such as sucrose, glucose, lactose, starch and citric acid.
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References
Seitz WR, Crit CRC (1981) Rev Anal Chem 13:1
Townshend A (1990) Analyst 115:495
Grayeski ML (1987) Anal Chem 59:1243A
Robards K, Worsfold P (1992) J Anal Chim Acta 266:147
Abbott RW, Townshend A, Gill R (1968) Analyst 111:635
Alwarthan AA, Townshend A (1986) Anal Chim Acta 185:329
Andrews ARJ, Townshend A (1989) Anal Chim Acta 227:65
Burguera JL, Townshend A (1980) Talanta 27:309
Faizullah AT, Townshend A (1985) Anal Proc 22:15
Nakagama T, Yamada M, Susuki S (1987) Anal Chim Acta 217:305
Al-Tamrah SA, Townshend A (1988) Anal Chim Acta 205:261
Koukli II, Calokerinos AC, Hadjiioannou TP (1989) Analyst 114:711
Townshend A, Murillo Pulgarín JA, Alañón Pardo MT (2003) Anal Chim Acta 488:81
Drugs of the future, vol 12 (1987) n°1
Borbe HO, Peter G (1990) Arzneim-Forsch 40:253
Niebch G, Borbe HO (1990) J Chromatogr Biomed Appl 534:247
Murillo Pulgarín JA, Alañón Molina A, Alañón Pardo MT (2001) Analyst 126:234
Murillo Pulgarín JA, Alañón Molina A, Alañón Pardo MT (2001) Fresenius J Anal Chem 371:903
Murillo Pulgarín JA, Alañón Molina A, Alañón Pardo MT (2002) Talanta 57:795
Barnett NW, Rolfe DG, Bowser TA, Paton TW (1993) Anal Chim Acta 282:551
Zhang ZD, Baeyens W, Zhang W, Van der Weken G (1996) J Pharm Biomed Anal 14:939
Koukli II, Sarantonis EG, Calokerinos AC (1990) Anal Lett 23:1167
Townshend A, Wheatley RA, Chisvert A, Salvador A (2002) Anal Chim Acta 462:209
IUPAC (1978) Nomenclature, symbols, units and their usage in spectrochemical analysis II. Spectrochim Acta B 33B:242
ACS Comittee on Environmental Improvement and Subcommitee on Environmental Analytical Chemistry (2242) Guidelines for data acquisition and data quality evaluation in environmental chemistry. Anal Chem 52:2242
Acknowledgements
The authors gratefully acknowledge financial support from the “Consejeríade Ciencia y Tecnología de la Junta de Comunidades de Castilla-La Mancha” (Project no. PBI-02-005) and “Fondo Social Europeo”. J.A. Murillo and M.T. Alañón also thank the Chemistry Department of the University of Hull for allowing this work to be carried out in its laboratories.
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Townshend, A., Pulgarín, J.M. & Pardo, M.A. Flow injection chemiluminescence determination of naftopidil based on potassium permanganate oxidation in the presence of formaldehyde or formic acid. Anal Bioanal Chem 381, 925–931 (2005). https://doi.org/10.1007/s00216-004-2998-y
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DOI: https://doi.org/10.1007/s00216-004-2998-y