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Recent advances in biosensing using magnetic glyconanoparticles

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Abstract

In this critical review we discuss the most recent advances in the field of biosensing applications of magnetic glyconanoparticles. We first give an overview of the main synthetic routes to obtain magnetic-nanoparticle–carbohydrate conjugates and then we highlight their most promising applications for magnetic relaxation switching sensing, cell and pathogen detection, cell targeting and magnetic resonance imaging. We end with a critical perspective of the field, identifying the main challenges to be overcome, but also the areas where the most promising developments are likely to happen in the coming decades.

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Acknowledgments

This work was funded by European Research Council Starting Grant 239931-NANOPUZZLE. J.M.F. acknowledges the SAF2014-54763-C2-2-R project (Spanish Government), European Regional and Social Development Funds, and the Aragón Autonomous Government (DGA) through Research Groups. R.M.F. acknowledges the University of Zaragoza and ARAID for financial support.

Conflict of interest

The authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Instituto de Nanociencia de Aragon, Universidad de Zaragoza, C/Mariano Esquillor s/n, 50018, Zaragoza, Spain

      Raluca M. Fratila & María Moros

    2. Fundación ARAID, C/María de Luna 11, Edificio CEEI Aragón, 50018, Zaragoza, Spain

      Raluca M. Fratila

    3. ICMA, CSIC/Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009, Zaragoza, Spain

      Jesús M. de la Fuente

    4. Institute of Nano Biomedicine and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education, Research Institute of Translation Medicine, Shanghai Jiao Tong University, Dongchuan Road 800, 200240, Shanghai, China

      Jesús M. de la Fuente

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    1. Raluca M. Fratila
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    Correspondence to Jesús M. de la Fuente.

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    Published in the topical collection Analytical Applications of Biomimetic Recognition Elements with guest editors Maria C. Moreno-Bondi and Elena Benito-Peña.

    Raluca M. Fratila and María Moros contributed equally to this work.

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    Fratila, R.M., Moros, M. & de la Fuente, J.M. Recent advances in biosensing using magnetic glyconanoparticles. Anal Bioanal Chem 408, 1783–1803 (2016). https://doi.org/10.1007/s00216-015-8953-2

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