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Mn2+-doped NaYF4:Yb/Er upconversion nanoparticle-based electrochemiluminescent aptasensor for bisphenol A

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Abstract

A novel aptasensor labeled with Mn2+-doped NaYF4:Yb/Er upconversion nanoparticles (NaYF4:Yb,Er/Mn UCNPs) was employed in electrogenerated chemiluminescence (ECL) for the sensitive detection of bisphenol A (BPA). The ECL aptasensor was assembled by immobilizing the thiolated aptamers of BPA covalently on a gold nanoparticle (AuNPs)-modified electrode and pairing with complementary DNA labeled with NaYF4:Yb,Er/Mn UCNPs. The ECL aptasensor can not only rapidly and accurately detect BPA concentrations from 0.05 to 100 ng/mL with a detection limit of 0.037 ng/mL but also provides a new platform for ECL applications based on the use of upconversion nanoparticles as a promising alternative material.

The NaYF4:Yb,Er/Mn UCNPs combining with the BPA aptamer serving as recognition elements create a ECL platform for the sensitive detection of bisphenol A. The change in ECL signals induced by aptamer-target interactions was measured and a significant decrease in intensity was found on interaction with BPA in the concentration range of 0.05 to 100 ng/mL.

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Acknowledgments

This work was partly supported by the National S&T Support Program of China (2015BAD17B02), NSFC (21375049, 31401576), JUSRP51309A, and Synergetic Innovation Center of Food Safety and Quality Control of Jiangsu Province.

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China

    Xiaofei Guo, Shijia Wu, Nuo Duan & Zhouping Wang

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  1. Xiaofei Guo
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  2. Shijia Wu
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  3. Nuo Duan
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  4. Zhouping Wang
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Correspondence to Zhouping Wang.

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Guo, X., Wu, S., Duan, N. et al. Mn2+-doped NaYF4:Yb/Er upconversion nanoparticle-based electrochemiluminescent aptasensor for bisphenol A. Anal Bioanal Chem 408, 3823–3831 (2016). https://doi.org/10.1007/s00216-016-9470-7

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  • DOI: https://doi.org/10.1007/s00216-016-9470-7

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