Skip to main content

Advertisement

SpringerLink
Log in

Effective CSF concentrations achieved with continuous-infusion flucloxacillin in a child

  • Letter to the Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Nau R, Sorgel F, Eiffert H (2010) Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev 23:858–883

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ (2004) Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 39:1267–1284

    Article  PubMed  Google Scholar 

  3. Autmizguine J, Moran C, Gonzalez D, Capparelli EV, Smith PB, Grant GA, Benjamin DK Jr, Cohen-Wolkowiez M, Watt KM (2014) Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections. Pediatr Infect Dis J 33:e270–e272

    Article  PubMed Central  PubMed  Google Scholar 

  4. McKamy S, Hernandez E, Jahng M, Moriwaki T, Deveikis A, Le J (2011) Incidence and risk factors influencing the development of vancomycin nephrotoxicity in children. J Pediatr 158:422–426

    Article  CAS  PubMed  Google Scholar 

  5. Villani P, Regazzi MB, Marubbi F, Viale P, Pagani L, Cristini F, Cadeo B, Carosi G, Bergomi R (2002) Cerebrospinal fluid linezolid concentrations in postneurosurgical central nervous system infections. Antimicrob Agents Chemother 46:936–937

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Grohs P, Kitzis MD, Gutmann L (2003) In vitro bactericidal activities of linezolid in combination with vancomycin, gentamicin, ciprofloxacin, fusidic acid, and rifampin against Staphylococcus aureus. Antimicrob Agents Chemother 47:418–420

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Nau R, Prange HW, Menck S, Kolenda H, Visser K, Seydel JK (1992) Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges. J Antimicrob Chemother 29:719–724

    Article  CAS  PubMed  Google Scholar 

  8. Drusano GL (2004) Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’. Nat Rev Microbiol 2:289–300

    Article  CAS  PubMed  Google Scholar 

  9. Lodise TP Jr, Lomaestro B, Drusano GL (2007) Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clin Infect Dis 44:357–363

    Article  CAS  PubMed  Google Scholar 

  10. Huang H, Huang S, Zhu P, Xi X (2014) Continuous versus intermittent infusion of cefepime in neurosurgical patients with post-operative intracranial infections. Int J Antimicrob Agents 43:68–72

    Article  CAS  PubMed  Google Scholar 

  11. Pullen J, de Rozario L, Stolk LM, Degraeuwe PL, van Tiel FH, Zimmermann LJ (2006) Population pharmacokinetics and dosing of flucloxacillin in preterm and term neonates. Ther Drug Monit 28:351–358

    Article  CAS  PubMed  Google Scholar 

  12. Abdul-Aziz MH, McDonald C, McWhinney B, Ungerer JP, Lipman J, Roberts JA (2014) Low flucloxacillin concentrations in a patient with central nervous system infection: the need for plasma and cerebrospinal fluid drug monitoring in the ICU. Ann Pharmacother 48:1380–1384

    Article  PubMed  Google Scholar 

Download references

Transparency declarations

None to declare.

Conflict of interest

The authors declare that they have no competing interests.

Funding

This study was carried out as part of our routine work.

Compliance with ethical standards

Consent was obtained from parents.

Contributions of author statement

AB and AG were responsible for the drafting of the manuscript. JC was responsible for the case report and figure. All authors contributed to the editing and final approval of the manuscript.

Author information

Authors and Affiliations

  1. Department of General Medicine, The Royal Children’s Hospital Melbourne, 50 Flemington Rd, Parkville, Victoria, 3052, Australia

    Alison Boast, Jeremy Carr, Nigel Curtis & Amanda Gwee

  2. Department of Paediatrics, The University of Melbourne, Parkville, 3010, Victoria, Australia

    Nigel Curtis & Amanda Gwee

  3. Murdoch Children’s Research Institute, 50 Flemington Rd, Parkville, 3052, Victoria, Australia

    Nigel Curtis & Amanda Gwee

  4. Department of Microbiology, The Royal Children’s Hospital Melbourne, 50 Flemington Rd, Parkville, 3052, Victoria, Australia

    Andrew J Daley

Authors
  1. Alison Boast
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jeremy Carr
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nigel Curtis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrew J Daley
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Amanda Gwee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Amanda Gwee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boast, A., Carr, J., Curtis, N. et al. Effective CSF concentrations achieved with continuous-infusion flucloxacillin in a child. Eur J Clin Pharmacol 71, 1535–1537 (2015). https://doi.org/10.1007/s00228-015-1928-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-015-1928-6

Keywords

Search

Navigation