Skip to main content

Advertisement

SpringerLink
Log in

The value of hypercalciuria in patients with osteopenia versus osteoporosis

  • Original Paper
  • Published:
Urolithiasis Aims and scope Submit manuscript

Abstract

The aim of this study was to analyze the presence of lithogenic metabolic factors in the blood and urine of patients with osteopenia versus osteoporosis. This is a cross-sectional study including 67 patients who were divided into two groups according to the presence of either osteopenia or osteoporosis as measured by bone densitometry: group 1—40 patients with osteopenia (22 men and 18 women) and group 2—27 patients with osteoporosis (13 men and 14 women). Metabolic studies were performed on the blood and urine; statistical analysis was performed comparing means and conducting linear correlation and multivariate analyses with SPSS. Statistical significance was considered to be p ≤ 0.05. The mean age of patients in group 1 was 52.9 ± 12.8 years versus 50.3 ± 11.4 in group 2; the difference was not statistically significant. In group 2, higher levels of osteocalcin, β-crosslaps, urinary calcium, fasting urine calcium/creatinine, 24 h urine calcium/creatinine and 24 h oxaluria were observed compared to group 1. In the multivariate analysis, only the β-crosslaps and urinary calcium were independently associated with osteoporosis. It would be advisable to determine the urinary calcium levels in patients with osteoporosis since altered levels may necessitate modifying the diagnostic and therapeutic approach to osteoporosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Olszynski WP, Shawn Davison K, Adachi JD, Brown JP, Cummings SR, Hanley DA, Harris SP, Hodsman AB, Kendler D, McClung MR, Miller PD, Yuen CK (2004) Osteoporosis in men: epidemiology, diagnosis, prevention, and treatment. Clin Ther 26:15–28

    Article  PubMed  Google Scholar 

  2. Gielen E, Vanderschueren D, Callewaert F, Boonen S (2011) Osteoporosis in men. Best Pract Res Clin Endocrinol Metab. 25:321–335

    Article  CAS  PubMed  Google Scholar 

  3. Painter SE, Kleerekoper M, Camacho PM (2006) Secondary osteoporosis: a review of the recent evidence. Endocr Pract. 12:436–445

    Article  PubMed  Google Scholar 

  4. Hudec SM, Camacho PM (2013) Secondary causes of osteoporosis. Endocr Pract 19:120–128

    Article  PubMed  Google Scholar 

  5. Polymeris A, Michalakis K, Sarantopoulou V (2013) Secondary osteoporosis—an endocrinological approach focusing on underlying mechanisms. Endocr Regul. 47:137–148

    Article  CAS  PubMed  Google Scholar 

  6. Arrabal Martín M, Fernández Rodríguez A, Arrabal Polo MA, Ruíz García MJ, Zuluaga Gómez A (2006) Study of the physical-chemical factors in patients with renal lithiasis. Arch Esp Urol 59:583–594

    PubMed  Google Scholar 

  7. Audran M, Legrand E (2000) Hypercalciuria. Joint Bone Spine. 67:509–515

    Article  CAS  PubMed  Google Scholar 

  8. Arrabal-Polo MA, del Carmen Cano-García M, Canales BK, Arrabal-Martín M (2014) Calcium nephrolithiasis and bone demineralization: pathophysiology, diagnosis, and medical management. Curr Opin Urol 24:633–638

    Article  PubMed  Google Scholar 

  9. Zerwekh JE (2010) Bone disease and hypercalciuria in children. Pediatr Nephrol 25:395–401

    Article  PubMed  Google Scholar 

  10. Skalova S, Palicka V, Kutilek S (2005) Bone mineral density and urinary N-acetyl-beta-D-glucosaminidase activity in paediatric patients with idiopathic hypercalciuria. Nephrology (Carlton) 10:99–102

    Article  CAS  Google Scholar 

  11. Penido MG, Lima EM, Marino VS, Tupinambá AL, França A, Souto MF (2003) Bone alterations in children with idiopathic hypercalciuria at the time of diagnosis. Pediatr Nephrol 18:133–139

    PubMed  Google Scholar 

  12. Ryan LE, Ing SW (2012) Idiopathic hypercalciuria and bone health. Curr Osteoporos Rep. 10:286–295

    Article  PubMed  Google Scholar 

  13. Bilić-Curcić I, Milas-Ahić J, Smolić M, Smolić R, Mihaljević I, Tucak-Zorić S (2009) Urolithiasis and osteoporosis: clinical relevance and therapeutic implications. Coll Antropol. 33(Suppl 2):189–192

    PubMed  Google Scholar 

  14. Ryan CS, Petkov VI, Adler RA (2011) Osteoporosis in men: the value of laboratory testing. Osteoporos Int 22:1845–1853

    Article  CAS  PubMed  Google Scholar 

  15. Cerdà D, Peris P, Monegal A, Albaladejo C, Martínez de Osaba MJ, Surís X, Guañabens N (2011) Increase of PTH in post-menopausal osteoporosis. Rev Clin Esp 211:338–343

    Article  PubMed  Google Scholar 

  16. Peris P, Ruiz-Esquide V, Monegal A, Alvarez L, Martínez de Osaba MJ, Martínez-Ferrer A, Reyes R, Guañabens N (2008) Idiopathic osteoporosis in premenopausal women. Clinical characteristics and bone remodelling abnormalities. Clin Exp Rheumatol 26:986–991

    CAS  PubMed  Google Scholar 

  17. Odabasi E, Turan M, Tekbas F, Kutlu M (2009) Evaluation of secondary causes that may lead to bone loss in women with osteoporosis: a retrospective study. Arch Gynecol Obstet 279:863–867

    Article  PubMed  Google Scholar 

  18. Carvalho M, Kulak CA, Borba VZ (2012) Prevalence of hypercalciuria in postmenopausal women with osteoporosis. Arq Bras Endocrinol Metabol. 56:1–5

    Article  PubMed  Google Scholar 

  19. Odvina CV, Poindexter JR, Peterson RD, Zerwekh JE, Pak CY (2008) Intestinal hyperabsorption of calcium and low bone turnover in hypercalciuric postmenopausal osteoporosis. Urol Res 36:233–239

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This article is a part of doctoral thesis by Maria Sierra Girón-Prieto in the Doctorado of Medicina Clinica and Salud Publica. Granada University. This investigation has been funded by Fundacion Progreso y Salud. Consejeria de Salud. Junta de Andalucia. Pi 0766/2013.

Author information

Authors and Affiliations

  1. Atención Primaria, Granada, Programa de doctorado de medicina clínica y salud pública, Universidad de Granada, Granada, Spain

    María Sierra Girón-Prieto

  2. UGC Urología intercentros, Hospital La Inmaculada, Huércal-Overa, Almeria, Spain

    María del Carmen Cano-García & Miguel Ángel Arrabal-Polo

  3. UGC Análisis Clínicos, Hospital Santa Ana, Motril, Granada, Spain

    Antonio Poyatos-Andújar

  4. Departamento de Medicina, Universidad de Granada, Granada, Spain

    Salvador Arias-Santiago

  5. UGC Análisis Clínicos intercentros, Hospital Universitario Granada, Granada, Spain

    Tomás de Haro-Muñoz

  6. UGC Urología intercentros, Hospital Universitario Granada, Granada, Spain

    Miguel Arrabal-Martín

Authors
  1. María Sierra Girón-Prieto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. María del Carmen Cano-García
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Antonio Poyatos-Andújar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Salvador Arias-Santiago
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tomás de Haro-Muñoz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Miguel Arrabal-Martín
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Miguel Ángel Arrabal-Polo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Miguel Ángel Arrabal-Polo.

Ethics declarations

Ethical statement

It is a low ethically responsible study in which the patients gave their informed consent after reading the Patient Information Sheet. The study was approved by the Hospital Ethics Committee.

Conflict of interest

The authors have no conflicts of interest to report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Girón-Prieto, M.S., del Carmen Cano-García, M., Poyatos-Andújar, A. et al. The value of hypercalciuria in patients with osteopenia versus osteoporosis. Urolithiasis 45, 279–283 (2017). https://doi.org/10.1007/s00240-016-0909-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00240-016-0909-2

Keywords

Search

Navigation