Abstract.
A whole blood prothrombin time/international normalized ratio (PT/INR) monitor (CoaguChek, Roche Diagnostics Corp., Indianapolis, IN) was assessed in children for its accuracy, reliability, safety, and acceptance by health care personnel and patient's families. The PT/INR values measured by the CoaguChek monitor showed an excellent correlation with PT/INR values measured by the Hospital for Sick Children (HSC) laboratory (r= 0.96) and Hamilton Civic Hospitals Research Centre (HCHRC) laboratory (r= 0.92) in clinic patients and a close correlation with PT/INR values measured by the HSC laboratory (r= 0.76) and HCHRC laboratory (r= 0.74) in patients at home. Reduced correlation in the home setting did not adversely affect clinical management. The whole blood PT/INR monitor is safe and accurate for children requiring oral anticoagulation therapy in either the outpatient clinic or home setting.
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Marzinotto, V., Monagle, P., Chan, A. et al. Capillary Whole Blood Monitoring of Oral Anticoagulants in Children in Outpatient Clinics and the Home Setting. Pediatr Cardiol 21, 347–352 (2000). https://doi.org/10.1007/s002460010078
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DOI: https://doi.org/10.1007/s002460010078