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Unraveling polyketide synthesis in members of the genus Aspergillus

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Abstract

Aspergillus species have the ability to produce a wide range of secondary metabolites including polyketides that are generated by multi-domain polyketide synthases (PKSs). Recent biochemical studies using dissected single or multiple domains from PKSs have provided deep insight into how these PKSs control the structural outcome. Moreover, the recent genome sequencing of several species has greatly facilitated the understanding of the biosynthetic pathways for these secondary metabolites. In this review, we will highlight the current knowledge regarding polyketide biosynthesis in Aspergillus based on the domain architecture of non-reducing, highly reducing, and partially reducing PKSs, and PKS-non-ribosomal peptide synthetases.

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Acknowledgments

The project described was supported by Grants Number PO1GM084077 and R01GM031837 from the National Institute of General Medical Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of General Medical Sciences or the National Institutes of Health.

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Authors and Affiliations

  1. Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan, Republic of China

    Yi-Ming Chiang

  2. Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, School of Pharmacy, 1985 Zonal Avenue, Los Angeles, CA, 90089, USA

    Yi-Ming Chiang & Clay C. C. Wang

  3. Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Ave, Lawrence, KS, 66045, USA

    Berl R. Oakley

  4. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, 53706, USA

    Nancy P. Keller

  5. Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, 53706, USA

    Nancy P. Keller

  6. Department of Chemistry, University of Southern California, College of Letters, Arts, and Sciences, Los Angeles, CA, 90089, USA

    Clay C. C. Wang

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  1. Yi-Ming Chiang
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  2. Berl R. Oakley
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  3. Nancy P. Keller
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  4. Clay C. C. Wang
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Correspondence to Clay C. C. Wang.

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Chiang, YM., Oakley, B.R., Keller, N.P. et al. Unraveling polyketide synthesis in members of the genus Aspergillus . Appl Microbiol Biotechnol 86, 1719–1736 (2010). https://doi.org/10.1007/s00253-010-2525-3

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