Skip to main content
Log in

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Slany RK (2005) When epigenetics kills: MLL fusion proteins in leukemia. Hematol Oncol 23:1–9

    Article  PubMed  CAS  Google Scholar 

  2. Sobulo OM, Borrow J, Tomek R et al (1997) MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proc Natl Acad Sci USA 94:8732–8737

    Article  PubMed  CAS  Google Scholar 

  3. Prince HM, Bishton MJ, Harrison SJ (2009) Clinical studies of histone deacetylase inhibitors. Clin Cancer Res 15:3958–3969

    Article  PubMed  CAS  Google Scholar 

  4. Prince HM, Bishton MJ, Johnstone RW (2009) Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors. Future Oncol 5:601–612

    Article  PubMed  CAS  Google Scholar 

  5. Neff T, Armstrong SA (2009) Chromatin maps, histone modifications and leukemia. Leukemia 23:1243–1251

    Article  PubMed  CAS  Google Scholar 

  6. Slany RK (2009) The molecular biology of mixed lineage leukemia. Haematologica 94:984–993

    Article  PubMed  CAS  Google Scholar 

  7. Dou Y, Hess JL (2008) Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia. Int J Hematol 87:10–18

    Article  PubMed  CAS  Google Scholar 

  8. Eklund EA (2007) The role of HOX genes in malignant myeloid disease. Curr Opin Hematol 14:85–89

    Article  PubMed  CAS  Google Scholar 

  9. Khobta A, Carlo-Stella C, Capranico G (2004) Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. Cancer Res 64:2656–2662

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kate L. Burbury.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Burbury, K.L., Bishton, M.J., Johnstone, R.W. et al. MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi). Ann Hematol 90, 847–849 (2011). https://doi.org/10.1007/s00277-010-1099-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-010-1099-6

Keywords

Navigation