References
Levine RL, Wadleigh M, Cools J et al (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7(4):387–397
Klampfl T, Gisslinger H, Harutyunyan AS et al (2013) Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med 369(25):2379–2390. doi:10.1056/NEJMoa1311347
Pikman Y, Lee BH, Mercher T et al (2006) MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med 3(7):e270
Kralovics R, Passamonti F, Buser AS et al (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352(17):1779–1790
Defour JP, Chachoua I, Pecquet C et al (2016) Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms. Leukemia 30:1214–1216
Chachoua I, Pecquet C, El-Khoury M et al (2016) Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood 127:1325–1335
Nangalia J, Massie CE, Baxter EJ et al (2013) Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med 369(25):2391–2405
Tefferi A, Pardanani A (2014) Genetics: CALR mutations and a new diagnostic algorithm for MPN. Nat Rev Clin Oncol 11(3):125–126. doi:10.1038/nrclinonc.2014.16
Tefferi A, Lasho TL, Finke CM et al (2014) CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons. Leukemia 28(7):1472–1477. doi:10.1038/leu.2014.3
Usseglio F, Beaufils N, Calleja A et al (2017) Detection of CALR and MPL mutations in low allelic burden JAK2 V617F essential thrombocythemia. J Mol Diagn 19(1):92–98. doi:10.1016/j.jmoldx.2016.08.006
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The authors like to thank Victoria Calvo for her technical assistance.
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Bernal, M., Jiménez, P., Puerta, J. et al. Co-mutated CALR and MPL driver genes in a patient with myeloproliferative neoplasm. Ann Hematol 96, 1399–1401 (2017). https://doi.org/10.1007/s00277-017-3023-9
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DOI: https://doi.org/10.1007/s00277-017-3023-9