Abstract
Objectives
To evaluate the temporal relationship between interval to biochemical recurrence (BCR) following radical prostatectomy (RP) and prostate cancer-specific mortality (PCSM).
Patients and methods
The study comprised of 2,116 men from the Victorian Radical Prostatectomy Register, a whole-of-population database of all RPs performed between 1995 and 2000 in Victoria, Australia. Follow-up prostate-specific antigen and death data were obtained via record linkage to pathology laboratories and the Victorian Registry of Births, Deaths and Marriages. Poisson regression models with PCSM as the outcome were fit to the data. Models included age at surgery, Gleason score and tumour stage as covariates.
Results
Median post-surgery and post-BCR follow-up was 10.3 and 7.5 years, respectively. 695 men (33 %) experienced BCR during follow-up, of which 82 % occurred within 5 years of RP; 66 men died from prostate cancer. Men with combined high Gleason sum (≥4 + 3) and extra-prostatic (≥pT3a) disease had substantially increased mortality rate with early BCR, while those experiencing BCR after a longer interval had significantly lower mortality. Men with combined low Gleason sum (≤3 + 4) and organ-confined disease (≤pT2c) risk disease were not at any substantial risk of death in this time frame regardless of timing of BCR following RP.
Conclusions
This study evaluates the temporal relationship between BCR and PCSM using a whole-of-population cohort of men treated with RP. Men with low-risk features of prostate cancer at time of RP have low mortality even if they experience early BCR. This subgroup may be counselled regarding their favourable long-term prognosis.
Similar content being viewed by others
References
Stamey TA, Yang N, Hay AR et al (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317:909–916
Han M, Partin AW, Zahurak M et al (2003) Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. J Urol 169:517–523
Porter CR, Kodama K, Gibbons RP et al (2006) 25-year prostate cancer control and survival outcomes: a 40-year radical prostatectomy single institution series. J Urol 176:569–574
Roehl KA, Han M, Ramos CG et al (2004) Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol 172:910–914
Boorjian SA, Karnes RJ, Crispen PL et al (2010) The impact of positive surgical margins on mortality following radical prostatectomy during the prostate specific antigen era. J Urol 183:1003–1009
Lodde M, Harel F, Lacombe L et al (2008) Substratification of high-risk localised prostate cancer treated by radical prostatectomy. World J Urol 26:225–229
Pound CR, Partin AW, Eisenberger MA et al (1999) Natural history of progression after PSA elevation following radical prostatectomy. JAMA 5(281):1591–1597
Ward JF, Blute ML, Slezak J (2003) The long-term clinical impact of biochemical recurrence of prostate cancer 5 or more years after radical prostatectomy. J Urol 170:1872–1876
Isbarn H, Wanner M, Salomon G et al (2010) Long-term data on the survival of patients with prostate cancer treated with radical prostatectomy in the prostate-specific antigen era. BJU Int 106:37–43
Stephenson AJ, Kattan MW, Eastham JA et al (2009) Prostate cancer-specific mortality after radical prostatectomy for patients treated in the prostate-specific antigen era. J Clin Oncol 10(27):4300–4305
Antonarakis ES, Feng Z, Trock BJ et al (2012) The natural history of metastatic progression in men with prostate-specific antigen recurrence after radical prostatectomy: long-term follow-up. BJU Int 109:32–39
Freedland SJ, Humphreys EB, Mangold LA et al (2005) Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy. JAMA 294:433–439
Freedland SJ, Humphreys EB, Mangold LA (2006) Time to prostate specific antigen recurrence after radical prostatectomy and risk of prostate cancer specific mortality. J Urol 176:1404–1408
Caire AA, Sun L, Ode O et al (2009) Delayed prostate-specific antigen recurrence after radical prostatectomy: how to identify and what are their clinical outcomes? Urology 74:643–647
Amling CL, Blute ML, Bergstralh EJ et al (2000) Long-term hazard of progression after radical prostatectomy for clinically localized prostate cancer: continued risk of biochemical failure after 5 years. J Urol 164:101–105
Loeb S, Feng Z, Ross A et al (2012) Can we stop prostate specific antigen testing 10 years after radical prostatectomy? J Urol 186:500–505
Albertsen PC, Hanley JA, Fine J (2005) 20-year outcomes following conservative management of clinically localized prostate cancer. JAMA 293:2095–2101
Johansson J-E, Andren O, Andersson SO et al (2004) Natural history of early, localized prostate cancer. JAMA 291:2713–2719
Bolton D, Severi G, Millar JL et al (2009) A whole of population-based series of radical prostatectomy in Victoria, 1995 to 2000. Aust N Z J Public Health 33:527–533
Trock BJ, Han M, Freedland SJ et al (2008) Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy. JAMA 18(299):2760–2769
Eggener SE, Scardino PT, Walsh PC et al (2011) Predicting 15-year prostate cancer specific mortality after radical prostatectomy. J Urol 185:869–875
Klotz L, Zhang L, Lam A et al (2010) Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer. J Clin Oncol 28:126–131
van den Bergh RCN, Vasarainen H, van der Poel HG et al (2010) Short-term outcomes of the prospective multicentre ‘Prostate Cancer Research International: Active Surveillance’ study. BJU Int 105:956–962
Walz J, Chun FKH, Klein EA et al (2009) Nomogram predicting the probability of early recurrence after radical prostatectomy for prostate cancer. J Urol 181:601–607 (discussion 7–8)
Mohler J, Bahnson RR, Boston B et al (2010) NCCN clinical practice guidelines in oncology: prostate cancer. J Natl Compr Canc Netw 8:162–200
Heidenreich A, Bellmunt J, Bolla M et al (2011) EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and treatment of clinically localised disease. Eur Urol 59:61–71
Ahove DA, Hoffman KE, Hu JC et al (2009) Which patients with undetectable PSA levels 5 years after radical prostatectomy are still at risk of recurrence?—implications for a risk-adapted follow-up strategy. Urology 76:1201–1205
Tollefson MK, Blute ML, Rangel LJ et al (2011) Lifelong yearly prostate specific antigen surveillance is not necessary for low risk prostate cancer treated with radical prostatectomy. J Urol 184:925–929
Acknowledgments
We want to thank participating urologists for their valuable contribution to the VRPR. Initial funding for this project was obtained from a grant in aid from Esso Australia. Ongoing support and infrastructure has been provided by The Cancer Council of Victoria and by the Whitten Foundation.
Conflict of interest
No member of the authorship group has, or did have at any time, any conflict of interest regarding the accrual or publication of the data obtained as part of this ongoing study.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bolton, D.M., Ta, A., Bagnato, M. et al. Interval to biochemical recurrence following radical prostatectomy does not affect survival in men with low-risk prostate cancer. World J Urol 32, 431–435 (2014). https://doi.org/10.1007/s00345-013-1125-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00345-013-1125-0