Skip to main content
Log in

Pseudophakes zystoides Makulaödem

Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenärzte Deutschlands. Stand 22.10.2022

Pseudophakic cystoid macular edema

Statement of the German Society of Ophthalmology, the German Retina Society and the German Professional Association of Ophthalmologists. Status 22 October 2022

  • Leitlinien, Stellungnahmen und Empfehlungen
  • Published:
Die Ophthalmologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Bertelmann T, Witteborn M, Mennel S (2012) Das pseudophakiebedingte zystoide Makulaodem. Klin Monbl Augenheilkd 229:798–811

    Article  CAS  PubMed  Google Scholar 

  2. Guo S, Patel S, Baumrind B et al (2015) Management of pseudophakic cystoid macular edema. Surv Ophthalmol 60:123–137

    Article  PubMed  Google Scholar 

  3. Han JV, Patel DV, Squirrell D et al (2019) Cystoid macular oedema following cataract surgery: a review. Clin Exp Ophthalmol 47:346–356

    Article  PubMed  Google Scholar 

  4. Radeck V, Marker D, Prahs P et al (2020) Pseudophakes zystoides Makulaödem. Ophthalmologe 117:579–590

    Article  PubMed  Google Scholar 

  5. Gass JD, Norton EW (1966) Cystoid macular edema and papilledema following cataract extraction. A fluorescein fundoscopic and angiographic study. Arch Ophthalmol 76:646–661

    Article  CAS  PubMed  Google Scholar 

  6. Chu CJ, Johnston RL, Buscombe C et al (2016) Risk factors and incidence of macular edema after cataract surgery: a database study of 81984 eyes. Ophthalmology 123:316–323

    Article  PubMed  Google Scholar 

  7. Tu KL, Kaye SB, Sidaras G et al (2007) Effect of intraocular surgery and ketamine on aqueous and serum cytokines. Mol Vis 13:1130–1137

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Chung YR, Kim YH, Lee SY et al (2019) Insights into the pathogenesis of cystoid macular edema: leukostasis and related cytokines. Int J Ophthalmol 12:1202–1208

    Article  PubMed  PubMed Central  Google Scholar 

  9. McCafferty S, Harris A, Kew C et al (2017) Pseudophakic cystoid macular edema prevention and risk factors; prospective study with adjunctive once daily topical nepafenac 0.3 % versus placebo. BMC Ophthalmol 17:16

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hollo G, Aung T, Cantor LB et al (2020) Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: mechanism, diagnosis, and management. Surv Ophthalmol 65:496–512

    Article  PubMed  Google Scholar 

  11. Miyake K, Ota I, Ibaraki N et al (2001) Enhanced disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema by topical timolol and its preservative in early postoperative pseudophakia. Arch Ophthalmol 119:387–394

    Article  CAS  PubMed  Google Scholar 

  12. Taipale C, Holmstrom EJ, Ilveskoski L et al (2019) Incidence of pseudophakic cystoid macular edema in eyes with and without pupil expansion device. Acta Ophthalmol 97:688–694

    Article  PubMed  Google Scholar 

  13. Blouin MC, Blouin J, Perreault S et al (2007) Intraoperative floppy-iris syndrome associated with alpha1-adrenoreceptors: comparison of tamsulosin and alfuzosin. J Cataract Refract Surg 33:1227–1234

    Article  PubMed  Google Scholar 

  14. Bradford JD, Wilkinson CP, Bradford RH Jr. (1988) Cystoid macular edema following extracapsular cataract extraction and posterior chamber intraocular lens implantation. Retina 8:161–164

    Article  CAS  PubMed  Google Scholar 

  15. Hunter AA, Modjtahedi SP, Long K et al (2014) Improving visual outcomes by preserving outer retina morphology in eyes with resolved pseudophakic cystoid macular edema. J Cataract Refract Surg 40:626–631

    Article  PubMed  Google Scholar 

  16. Kessel L, Tendal B, Jorgensen KJ et al (2014) Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: a systematic review. Ophthalmology 121:1915–1924

    Article  PubMed  Google Scholar 

  17. Lim BX, Lim CH, Lim DK et al (2016) Prophylactic non-steroidal anti-inflammatory drugs for the prevention of macular oedema after cataract surgery. Cochrane Database Syst Rev 11:CD6683

    PubMed  Google Scholar 

  18. Wielders LH, Lambermont VA, Schouten JS et al (2015) Prevention of cystoid macular edema after cataract surgery in nondiabetic and diabetic patients: a systematic review and meta-analysis. Am J Ophthalmol 160:968–981.e33

    Article  PubMed  Google Scholar 

  19. Wielders LHP, Schouten J, Winkens B et al (2018) European multicenter trial of the prevention of cystoid macular edema after cataract surgery in nondiabetics: ESCRS PREMED study report 1. J Cataract Refract Surg 44:429–439

    Article  PubMed  Google Scholar 

  20. Donnenfeld ED, Perry HD, Wittpenn JR et al (2006) Preoperative ketorolac tromethamine 0.4 % in phacoemulsification outcomes: pharmacokinetic-response curve. J Cataract Refract Surg 32:1474–1482

    Article  PubMed  Google Scholar 

  21. Yavas GF, Ozturk F, Kusbeci T (2007) Preoperative topical indomethacin to prevent pseudophakic cystoid macular edema. J Cataract Refract Surg 33:804–807

    Article  PubMed  Google Scholar 

  22. Grzybowski A, Sikorski BL, Ascaso FJ et al (2016) Pseudophakic cystoid macular edema: update 2016. Clin Interv Aging 11:1221–1229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Guidera AC, Luchs JI, Udell IJ (2001) Keratitis, ulceration, and perforation associated with topical nonsteroidal anti-inflammatory drugs. Ophthalmology 108:936–944

    Article  CAS  PubMed  Google Scholar 

  24. Miller KM, Oetting TA, Tweeten JP et al (2022) Cataract in the adult eye preferred practice pattern. Ophthalmology 129:P1–P126

    Article  PubMed  Google Scholar 

  25. NICE Cataracts in adults. https://www.nice.org.uk/guidance/ng77. Zugegriffen: 2022-08-28

  26. Wielders LHP, Schouten J, Winkens B et al (2018) Randomized controlled European multicenter trial on the prevention of cystoid macular edema after cataract surgery in diabetics: ESCRS PREMED study report 2. J Cataract Refract Surg 44:836–847

    Article  PubMed  Google Scholar 

  27. Schilling H, Pauleikhoff D, Schrenk M et al (1993) Therapie zystoider und diffuser Makulaodeme nach Uveitis und Katarakt-Chirurgie mit dem Carboanhydrase-Hemmer Acetazolamid (Diamox). Klin Monbl Augenheilkd 202:206–211

    Article  CAS  PubMed  Google Scholar 

  28. Pepple KL, Nguyen MH, Pakzad-Vaezi K et al (2019) Response of inflammatory cystoid macular edema to treatment using oral acetazolamide. Retina 39:948–955

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kuley B, Storey PP, Wibbelsman TD et al (2021) Resolution of pseudophakic cystoid macular edema: 2 mg Intravitreal triamcinolone acetonide versus 40 mg posterior sub-tenon triamcinolone acetonide. Curr Eye Res 46:824–830

    Article  CAS  PubMed  Google Scholar 

  30. Orski M, Gawecki M (2021) Current management options in Irvine-Gass syndrome: a systemized review. J Clin Med. https://doi.org/10.3390/jcm10194375

    Article  PubMed  PubMed Central  Google Scholar 

  31. Tariq F, Wang Y, Ma B et al (2022) Efficacy of intravitreal injection of filtered modified low-dose triamcinolone acetonide and ranibizumab on pseudophakic cystoid macular edema. Front Med (Lausanne) 9:777549

    Article  PubMed  PubMed Central  Google Scholar 

  32. Bellocq D, Pierre-Kahn V, Matonti F et al (2017) Effectiveness and safety of dexamethasone implants for postsurgical macular oedema including Irvine-Gass syndrome: the EPISODIC-2 study. Br J Ophthalmol 101:333–341

    PubMed  Google Scholar 

  33. Spitzer MS, Ziemssen F, Yoeruek E et al (2008) Efficacy of intravitreal bevacizumab in treating postoperative pseudophakic cystoid macular edema. J Cataract Refract Surg 34:70–75

    Article  PubMed  Google Scholar 

  34. Staurenghi G, Lai TYY, Mitchell P et al (2018) Efficacy and safety of ranibizumab 0.5 mg for the treatment of macular edema resulting from uncommon causes: twelve-month findings from PROMETHEUS. Ophthalmology 125:850–862

    Article  PubMed  Google Scholar 

Download references

Redaktionskomitee

Klaus Dieter Lemmen (federführend); Bernd Bertram; Norbert Bornfeld; Horst Helbig; Hans Hoerauf; Carsten Heinz; Uwe Pleyer; Daniela Claessens (Literaturrecherche)

Author information

Authors and Affiliations

Consortia

Ethics declarations

Interessenkonflikt

Siehe Tab. 1 im Anhang.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Additional information

Diese Leitlinie erscheint ebenfalls in der Zeitschrift Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag, Stuttgart.

Das Redaktionskomitee dieser Stellungnahme wird am Beitragsende gelistet.

figure qr

QR-Code scannen & Beitrag online lesen

Anhang

Anhang

Im Folgenden sind die Interessenerklärungen als tabellarische Zusammenfassung dargestellt sowie die Ergebnisse der Interessenkonfliktbewertung und Maßnahmen, die nach Diskussion der Sachverhalte von der LL-Gruppe beschlossen und im Rahmen der Konsensuskonferenz umgesetzt wurden.

  • Leitlinienkoordination: Bertram, Bernd

  • Leitlinie: Pseudophakes zystoides Makulaödem (PZMÖ) nach Kataraktoperation

  • Registernummer: Stellungnahme

Tab. 1 Erklärung von Interessen und Umgang mit Interessenkonflikten

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Deutsche Ophthalmologische Gesellschaft (DOG)., Retinologische Gesellschaft e. V. (RG). & Berufsverband der Augenärzte Deutschlands e. V. (BVA). Pseudophakes zystoides Makulaödem. Ophthalmologie 120, 276–284 (2023). https://doi.org/10.1007/s00347-022-01771-8

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-022-01771-8

Navigation