Skip to main content
Log in

Successful acute and long-term management of electrical storm in Brugada syndrome using orciprenaline and quinine/quinidine

  • Clinical Correspondence
  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Brugada P, Brugada J (1992) Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 20:1391–1396

    Article  CAS  PubMed  Google Scholar 

  2. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A (2005) Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 111:659–670

    Article  PubMed  Google Scholar 

  3. Antzelevitch C (2006) Brugada syndrome. Pacin Clin Electrophysiol 29:1130–1159

    Article  Google Scholar 

  4. Nägele H, Behrens S, Castel A (2008) Ventricular tachycardia and aggravation of Brugada ECG pattern in a patient with coronary artery disease and combined amiodarone and betablocker therapy. Clin Res Cardiol 97:56–60

    Article  PubMed  Google Scholar 

  5. Veltmann C, Kuschyk J, Schimpf R, Streitner F, Schoene N, Borggrefe M, Wolpert C (2010) Prevention of inappropriate ICD shocks in patients with Brugada syndrome. Clin Res Cardiol 99:37–44

    Article  PubMed  Google Scholar 

  6. Wolpert C, Echternach C, Veltmann C, Antzelevitch C, Thomas GP, Spehl S, Streitner F, Kuschyk J, Schimpf R, Haase KK, Borggrefe M (2005) Intravenous drug challenge using flecainide and ajmaline in patients with Brugada syndrome. Heart Rhythm 2:254–260

    Article  PubMed  Google Scholar 

  7. Antz M, Berodt K, Bänsch D, Ernst S, Chun KJ, Satomi K, Schmidt B, Boczor S, Ouyang F, Kuck KH (2008) Catheter-ablation of ventricular tachycardia in patients with coronary artery disease: influence of the endocardial substrate size on clinical outcome. Clin Res Cardiol 97:110–117

    Article  PubMed  Google Scholar 

  8. Kettering K, Kampmann C, Mollnau H, Kreitner KF, Münzel T, Weiss C (2009) Catheter ablation of an incessant ventricular tachycardia originating from the left aortic sinus cusp in an adolescent with subacute myocarditis. Clin Res Cardiol 98:66–70

    Article  PubMed  Google Scholar 

  9. Lenz C, Dietze T, Möller M, Schöbel W, Wicke J, Kellner HJ, Gradaus R, Neuzner J (2009) Incessant ventricular tachycardia, refractory to catheter ablation, in an ICD patient terminated by ICD lead extraction: a case report. Clin Res Cardiol 98:803–805

    Article  PubMed  Google Scholar 

  10. Letsas KP, Efremidis M, Kounas SP, Pappas LK, Gavrielatos G, Alexanian IP, Dimopoulos NP, Filippatos GS, Sideris A, Kardaras F (2009) Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors. Clin Res Cardiol 98:208–212

    Article  PubMed  Google Scholar 

  11. Chalvidan T, Deharo JC, Dieuzaide P, Defaye P, Djiane P (2000) Near fatal electrical storm in a patient equipped with an implantable cardioverter defibrillator for Brugada syndrome. Pacing Clin Electrophysiol 23:410–412

    Article  CAS  PubMed  Google Scholar 

  12. Dinckal MH, Davutoglu V, Akdemir I, Soydinc S, Kirilmaz A, Aksoy M (2003) Incessant monomorphic ventricular tachycardia during febrile illness in a patient with Brugada syndrome: fatal electrical storm. Europace 5:257–261

    Article  CAS  PubMed  Google Scholar 

  13. Maury P, Hocini M, Haissaguerre M (2005) Electrical storms in Brugada syndrome: review of pharmacologic and ablative therapeutic options. Indian Pacing Electrophysiol J 5:25–34

    CAS  PubMed  Google Scholar 

  14. Ayerza MR, De Zutter M, Goethals M, Wellens F, Geelen P, Brugada P (2002) Heart transplantation as last resort against Brugada syndrome. J Cardiovasc Electrophysiol 13:943–944

    Article  PubMed  Google Scholar 

  15. Nakagawa E, Takagi M, Tatsumi H, Yoshiyama M (2008) Successful radiofrequency ablation for electrical storm of ventricular fibrillation in a patient with Brugada syndrome. Circ J 72:1025–1029

    Article  PubMed  Google Scholar 

  16. Voss F, Bauer A, Witte S, Katus HA, Becker R (2008) Can noncontact mapping distinguish between endo- and epicardial foci? Clin Res Cardiol 97:734–741

    Article  PubMed  Google Scholar 

  17. Pagel PS, Lilly RE, Nicolosi AC (2009) Use of ECMO to temporize circulatory instability during severe Brugada electrical storm. Ann Thorac Surg 88:982–983

    Article  PubMed  Google Scholar 

  18. Maury P, Couderec P, Delay M, Boveda S, Brugada J (2004) Electrical storm in Brugada syndrome successfully treated using isoprenaline. Europace 6:130–133

    Article  CAS  PubMed  Google Scholar 

  19. Shah M, Akar FG, Tomaselli GF (2005) Molecular basis of arrhythmias. Circulation 112:2517–2529

    Article  PubMed  Google Scholar 

  20. Jongman JK, Jepkes-Bruin N, Ramdat Misier AR, Beukema WP, Delnoy PPHM, Oude Luttikhuis H, Dambrink JHE, Hoorntje JCA, Elvan A (2007) Electrical storms in Brugada syndrome successfully treated with isoproterenol infusion and quinidine orally. Neth Heart J 15:151–154

    CAS  PubMed  Google Scholar 

  21. Joshi S, Raiszadeh F, Pierce W, Steinberg JS (2007) Antiarrhythmic induced electrical storm in Brugada syndrome: a case report. Ann Noninvasive Electrocardiol 12:274–278

    Article  PubMed  Google Scholar 

  22. Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S, Ohe T, Shimizu W (2007) Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm 4:701–702

    Article  Google Scholar 

  23. Kyriazis K, Bahlmann E, van der Schalk H, Kuck KH (2009) Electrical storm in Brugada syndrome successfully treated with orciprenaline; effect of low-dose quinidine on the electrocardiogram. Europace 11:665–666

    Article  PubMed  Google Scholar 

  24. Belhassen B, Glick A, Viskin S (2004) Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 110:1731–1737

    Article  PubMed  Google Scholar 

  25. Mok NS, Chan NY, Chiu ACS (2004) Successful use of quinidine in treatment of electrical storm in Brugada syndrome. Pacing Clin Electrophysiol 27:821–823

    Article  PubMed  Google Scholar 

  26. Michel D, Wegener JW, Nawrath H (2002) Effects of quinine and quinidine on the transient outward and on the L-type Ca2+ current in rat ventricular cardiomyocytes. Pharmacology 65:187–192

    Article  CAS  PubMed  Google Scholar 

  27. Viskin S, Antzelevitch C, Marquez MF, Belhassen B (2007) Quinidine: a valuable medication joins the list of “endangered species”. Europace 9:1105–1106

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported in part by grants from the University of Heidelberg (FRONTIERS program), from the ADUMED-Foundation, and from the Max Planck Society (TANDEM program).

Conflict of interest statement

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dierk Thomas.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schweizer, P.A., Becker, R., Katus, H.A. et al. Successful acute and long-term management of electrical storm in Brugada syndrome using orciprenaline and quinine/quinidine. Clin Res Cardiol 99, 467–470 (2010). https://doi.org/10.1007/s00392-010-0145-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-010-0145-7

Keywords

Navigation