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Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer

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European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

The main objective of this study was to test the therapeutic potential of hydroxytyrosol and its combination with paclitaxel in breast cancer on oxidative stress status.

Methods

Impact on proliferation rates of different chemotherapy administration patterns was assayed in MCF-7 and MDA-MB-231 breast cancer cell lines. Breast tumor-bearing rats were randomly assigned to Control, Hydroxytyrosol, Paclitaxel and Paclitaxel plus hydroxytyrosol groups, for 6 weeks. Tumor volume, cell proliferation and several systemic oxidative stress parameters were measured. Anti-proliferative activity in vitro experiments was correlated with in vivo experiments.

Results

Combination group did significantly reduce tumor volume when compared with paclitaxel alone. Additionally, the combination improved the antioxidant status without compromising the antitumor activity of standard chemotherapy.

Conclusion

These findings reveal for the first time that hydroxytyrosol is an active partner in combined therapies with paclitaxel against breast cancer. Combination with hydroxytyrosol would also ensure a less oxidative impact of chemotherapeutic drugs that could potentially improve patient wellness.

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Acknowledgements

This research was supported by Grants from Excelentísima Diputación de Jaén, CEAS Foundation 30.C0.244500 and Junta de Andalucía PI-0210/2007.

Author information

Authors and Affiliations

  1. “José Mataix” Institute of Nutrition and Food Technology, Biomedical Research Centre, Health Sciences Technological Park, University of Granada, 18016, Armilla, Granada, Spain

    Nuri El-azem, Mario Pulido-Moran, Jose L. Quiles, Sergio Granados-Principal & MCarmen Ramirez-Tortosa

  2. Department of Biochemistry and Molecular Biology II, University of Granada, 18016, Armilla, Granada, Spain

    Mario Pulido-Moran & MCarmen Ramirez-Tortosa

  3. Department of Pathological Anatomy, Hospital Complex of Jaén, Jaén, Spain

    Cesar L. Ramirez-Tortosa

  4. Department of Physiology, University of Granada, Granada, Spain

    Jose L. Quiles

  5. Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA

    Francisca E. Cara

  6. Oncology Service, Jaen City Hospital, Jaén, Spain

    Pedro Sanchez-Rovira

  7. Methodist Cancer Center, Houston Methodist Hospital, Houston, TX, USA

    Sergio Granados-Principal

Authors
  1. Nuri El-azem
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  2. Mario Pulido-Moran
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  4. Jose L. Quiles
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  6. Pedro Sanchez-Rovira
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  8. MCarmen Ramirez-Tortosa
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Correspondence to MCarmen Ramirez-Tortosa.

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Manuscript submitted for publication has been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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El-azem, N., Pulido-Moran, M., Ramirez-Tortosa, C.L. et al. Modulation by hydroxytyrosol of oxidative stress and antitumor activities of paclitaxel in breast cancer. Eur J Nutr 58, 1203–1211 (2019). https://doi.org/10.1007/s00394-018-1638-9

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  • DOI: https://doi.org/10.1007/s00394-018-1638-9

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