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Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

  • Original Contribution
  • Published:
European Journal of Nutrition Aims and scope Submit manuscript

Abstract

Purpose

Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study.

Methods

The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires.

Results

During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases.

Conclusions

In this large prospective study, coffee and tea consumptions were not associated with TC risk.

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Data Availability

For information on how to submit an application for gaining access to EPIC data and/or biospecimens, please follow the instructions at http://epic.iarc.fr/access/index.php.

Abbreviations

24-HDR:

24-h dietary recall

BMI:

Body mass index

CI:

Confidence interval

EPIC:

European Prospective Investigation into Cancer and Nutrition

HR:

Hazard ratio

IARC:

International Agency for Research on Cancer

NOS:

Not otherwise specified

TC:

Thyroid cancer

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Acknowledgements

We thank Mr. Bertrand Hémon for his valuable help with the EPIC database. The authors also thank all participants in the EPIC cohorts for their invaluable contribution to the study.

Funding

This study was supported by the Institute of Health Carlos III, Spain (CP15/00100), and cofounded by the European Regional Development Fund (ERDF) “A way to build Europe”. The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, AGAUR, Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds (RD12/0036/0018) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom). RZ-R would like to thank the “Miguel Servet” program (CP15/00100) from the Institute of Health Carlos III (Spain) and the European Social Fund (ESF).

Author information

Authors and Affiliations

  1. Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Av Gran Via 199-203, 08908, L’Hospitalet de Llobregat, Spain

    Raul Zamora-Ros, Muath A. Alghamdi, Valerie Cayssials & Antonio Agudo

  2. College of Medicine, Al Imam Mohammed Ibn Saud Islamic University, Riyadh, Saudi Arabia

    Muath A. Alghamdi

  3. Epidemiology Unit, Aviano Cancer Center, Milan, Italy

    Silvia Franceschi

  4. Department of Surgery, Skåne University Hospital Malmö, Lund University, Lund, Sweden

    Martin Almquist & Jonas Manjer

  5. Malmö Diet and Cancer Study, University Hospital Malmö, Malmö, Sweden

    Martin Almquist

  6. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden

    Joakim Hennings

  7. Department for Radiation Sciences, Umeå University, Umeå, Sweden

    Maria Sandström

  8. Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece

    Konstantinos K. Tsilidis

  9. School of Public Health, Imperial College London, London, UK

    Konstantinos K. Tsilidis, H. Bas Bueno-de-Mesquita & Dagfinn Aune

  10. Department of Community Medicine, Faculty of Health Sciences, UiT, The Arctic University of Tromsø, Tromsö, Norway

    Elisabete Weiderpass, Guri Skeie & Tonje Braaten

  11. Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway

    Elisabete Weiderpass

  12. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

    Elisabete Weiderpass

  13. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland

    Elisabete Weiderpass

  14. CESP, Université Paris-Sud, UVSQ, INSERM, Université Paris-Saclay, Villejuif, France

    Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh & Fabrice Bonnet

  15. Institut Gustave Roussy, Villejuif, France

    Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh & Fabrice Bonnet

  16. Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

    Bodil Hammer Bech & Kim Overvad

  17. Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark

    Anne Tjønneland & Kristina E. N. Petersen

  18. CHU Rennes, Université de Rennes 1, Rennes, France

    Fabrice Bonnet

  19. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany

    Tilman Kühn & Renée T. Fortner

  20. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

    Heiner Boeing

  21. Hellenic Health Foundation, Athens, Greece

    Antonia Trichopoulou, Christina Bamia & Georgia Martimianaki

  22. Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Nutrition and Health, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

    Antonia Trichopoulou & Christina Bamia

  23. Cancer Risk Factors and Life-Style Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy

    Giovanna Masala

  24. Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Sara Grioni

  25. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

    Salvatore Panico

  26. Cancer Registry and Histopathology Unit, “Civic M.P. Arezzo” Hospital, ASP Ragusa, Ragusa, Italy

    Rosario Tumino

  27. Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and University of Turin, Turin, Italy

    Francesca Fasanelli

  28. Department of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain

    Cristina Lasheras

  29. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain

    Elena Salamanca-Fernández

  30. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

    Elena Salamanca-Fernández, Pilar Amiano, Maria-Dolores Chirlaque & Aurelio Barricarte

  31. Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia, Spain

    Pilar Amiano

  32. Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain

    Maria-Dolores Chirlaque

  33. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain

    Maria-Dolores Chirlaque

  34. Navarra Public Health Institute, Pamplona, Spain

    Aurelio Barricarte

  35. Navarra Institute for Health Research (IdiSNA), Pamplona, Spain

    Aurelio Barricarte

  36. Nutrition Epidemiology Research Group, Department of Clinical Sciences, Lund University, Malmö, Sweden

    Peter Wallström

  37. Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands

    H. Bas Bueno-de-Mesquita

  38. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands

    H. Bas Bueno-de-Mesquita

  39. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

    H. Bas Bueno-de-Mesquita

  40. Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Petra H. Peeters

  41. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

    Kay-Thee Khaw

  42. MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK

    Nicholas J. Wareham

  43. Cancer Epidemiology Unit, University of Oxford, Oxford, UK

    Julie A. Schmidt

  44. International Agency for Research on Cancer (IARC), Lyon, France

    Graham Byrnes, Augustin Scalbert & Sabina Rinaldi

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  1. Raul Zamora-Ros
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  2. Muath A. Alghamdi
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  3. Valerie Cayssials
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  4. Silvia Franceschi
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  5. Martin Almquist
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  7. Maria Sandström
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  8. Konstantinos K. Tsilidis
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  9. Elisabete Weiderpass
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  10. Marie-Christine Boutron-Ruault
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  11. Bodil Hammer Bech
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  14. Kristina E. N. Petersen
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  18. Tilman Kühn
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  21. Antonia Trichopoulou
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  24. Giovanna Masala
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  25. Sara Grioni
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  26. Salvatore Panico
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  27. Rosario Tumino
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  28. Francesca Fasanelli
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  29. Guri Skeie
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  30. Tonje Braaten
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  31. Cristina Lasheras
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  32. Elena Salamanca-Fernández
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  33. Pilar Amiano
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  34. Maria-Dolores Chirlaque
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  35. Aurelio Barricarte
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  36. Jonas Manjer
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  37. Peter Wallström
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  38. H. Bas Bueno-de-Mesquita
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  42. Julie A. Schmidt
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Contributions

RZ-R, SF, and SR designed the research; RZ-R, MAA, and VC performed the statistical analyses; RZ-R and MAA drafted the manuscript; SF, MA, JH, MS, KKT, EW, M-CB-R, GB, AS, AA, and SR contributed to the discussion. All authors reviewed, edited, and approved the final manuscript.

Corresponding author

Correspondence to Raul Zamora-Ros.

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Conflict of interest

Zamora-Ros R, Alghamdi MA, Cayssials V, Franceschi S, Almquist M, Hennings J, Sandström M, Tsilidis KK, Weiderpass E, Boutron-Ruault M-C, Hammer Bech B, Overvad K, Tjønneland A, Petersen KEN, Mancini FR, Mahamat-Saleh Y, Bonnet F, Kühn T, Fortner RT, Boeing H, Trichopoulou A, Bamia C, Martimianaki G, Masala G, Grioni S, Panico S, Tumino R, Fasanelli F, Skeie G, Braaten T, Lasheras C, Salamanca-Fernández E, Amiano P, Chirlaque M-D, Barricarte A, Manjer J, Wallström P, Bueno-de-Mesquita HB, Peeters PH, Khaw K-T, Wareham NJ, Schmidt JA, Aune D, Byrnes G, Scalbert A, Agudo A, and Rinaldi S have no conflict of interest.

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Zamora-Ros, R., Alghamdi, M.A., Cayssials, V. et al. Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr 58, 3303–3312 (2019). https://doi.org/10.1007/s00394-018-1874-z

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  • DOI: https://doi.org/10.1007/s00394-018-1874-z

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