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Modeling of the effect of fluorocarbon gases on the properties of phospholipid monolayers and the adsorption dynamics of their aqueous solutions or dispersions

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Abstract

An equation of state for insoluble monolayers was applied to describe the isotherms of phospholipids measured in presence of a fluorocarbon in the gas phase. The observed co-adsorption mechanism of dipalmitoylphosphatidylcholine (DPPC) and the fluorocarbon molecules manifests itself in remarkable differences of the cohesion surface pressure Π coh. Due to the interaction of the adsorbed fluorocarbon molecules with DPPC, the mutual interaction energy between DPPC molecules is reduced, leading to a very effective fluidization of the monolayer. Equilibrium and dynamic surface tension data taken from literature for phospholipids adsorbed from an aqueous solution or dispersion, in absence and presence of perfluorohexane (PFH) in the adjacent vapor phase, have been analyzed by the proposed theory. It was found that the adsorption equilibrium constant for dioctanoylphosphatidylcholine (di-C8PC) is increased in the presence of PFH and the intermolecular interaction between the components is strong. The dynamic surface tensions of the given systems are described by a diffusion-controlled adsorption mechanism.

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Acknowledgments

The work was financially supported by a project of the European Space Agency (FASES MAP and PASTA), by the COST actions CM1101 and MP1106, and by the French National Research Agency (ANR-14-CE35-0028-01).

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Authors and Affiliations

  1. Institut Charles Sadron, CNRS, University of Strasbourg, Strasbourg, France

    Marie Pierre Krafft

  2. Donetsk Medical University, Donetsk, Ukraine

    Valentin B. Fainerman

  3. MPI of Colloids and Interfaces, Potsdam, Germany

    Reinhard Miller

Authors
  1. Marie Pierre Krafft
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  2. Valentin B. Fainerman
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  3. Reinhard Miller
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Correspondence to Reinhard Miller.

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Krafft, M.P., Fainerman, V.B. & Miller, R. Modeling of the effect of fluorocarbon gases on the properties of phospholipid monolayers and the adsorption dynamics of their aqueous solutions or dispersions. Colloid Polym Sci 293, 3091–3097 (2015). https://doi.org/10.1007/s00396-015-3622-8

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  • DOI: https://doi.org/10.1007/s00396-015-3622-8

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