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Magnetic hyperthermia with magnetite nanoparticles: electrostatic and polymeric stabilization

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Abstract

In this work, magnetic hyperthermia, i.e., heating induced by an alternating magnetic field acting on a magnetic suspension, is considered in three main aspects. The first one regards the implementation of a simple device for producing AC magnetic fields. The second contribution concerns the comparison of the hyperthermia response (measured by the specific absorption rate (SAR)) of magnetite nanoparticles of two different sizes and of raw particles vs. polyelectrolyte-coated ones. An improvement is observed of the SAR values when the pH is fixed away from the isoelectric point or when the ionic strength is kept at low values. The addition of a polymer enhances significantly the stability of the suspensions and so does with the SAR values. Finally, we describe the implementation of a sort of magnetic hyperthermia applicator, avoiding the necessity of placing the magnetic sample inside the coil and making it of more practical use.

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Acknowledgments

Financial support for this work from Junta de Andalucía, Spain (project PE2012-FQM-0694), University of Granada-CEI Biotic (BS27.2015), MICINN, Spain (project FIS2013-47666-C03-01-R), FEDER Funds, EU, and RYC-2014-16901 (MINECO) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Applied Physics, University of Granada, 18071, Granada, Spain

    G. Iglesias & A.V. Delgado

  2. Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, Poland

    M. Kujda

  3. Department of Physics, University of Jaén, 23700, Linares, Spain

    M.M. Ramos-Tejada

  4. Departamento de Física Aplicada, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain

    A.V. Delgado

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  1. G. Iglesias
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  2. A.V. Delgado
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  4. M.M. Ramos-Tejada
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Correspondence to A.V. Delgado.

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Iglesias, G., Delgado, A., Kujda, M. et al. Magnetic hyperthermia with magnetite nanoparticles: electrostatic and polymeric stabilization. Colloid Polym Sci 294, 1541–1550 (2016). https://doi.org/10.1007/s00396-016-3918-3

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