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Intrasellar malignant lymphoma developing within pituitary adenoma

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Acta Neuropathologica Aims and scope Submit manuscript

Abstract

A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogenetic pathways for intra-adenomatous lymphoma development include monoclonal expansion of T cell infiltrates, expression of adhesion molecules specific for adenoma endothelium, and production of mitogenic pituitary hormones.

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Authors and Affiliations

  1. Department of Neuropathology, University of Erlangen, Erlangen, Germany, , , , , , DE

    Dorothee Kuhn & Werner Paulus

  2. Department of Neurosurgery, University of Erlangen, Erlangen, Germany, , , , , , DE

    Michael Buchfelder

  3. Department of Pathology, University of Erlangen, Erlangen, Germany, , , , , , DE

    Thomas Brabletz

Authors
  1. Dorothee Kuhn
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  2. Michael Buchfelder
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  3. Thomas Brabletz
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  4. Werner Paulus
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Additional information

Received: 4 August 1998 / Revised: 29 August 1998 / Accepted: 14 September 1998

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Kuhn, D., Buchfelder, M., Brabletz, T. et al. Intrasellar malignant lymphoma developing within pituitary adenoma. Acta Neuropathol 97, 311–316 (1999). https://doi.org/10.1007/s004010050990

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  • DOI: https://doi.org/10.1007/s004010050990

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