Skip to main content

Advertisement

SpringerLink
Log in

LncRNA–miRNA–mRNA regulatory axes in endometrial cancer: a comprehensive overview

  • Review
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

Recent research on tumorigenesis and progression has opened up an array of novel molecular mechanisms in the form of interactions between cellular non-coding RNAs (long non-coding RNA[lncRNA]/microRNA [miRNA]) and coding transcripts that regulate health and disease. Endometrial cancer (EC) is a prominent gynecological malignancy with a high incidence rate and poorly known etiology and prognostic factors that hinder the success of disease management. The emerging role of lncRNA–miRNA–mRNA interactions and their dysregulation in the pathophysiology of EC has been elucidated in many recent studies.

Methods

A thorough literature review was conducted to explore information about lncRNA–miRNA–mRNA axes in EC.

Results

Several lncRNAs act as molecular sponges that sequester various tumor suppressor miRNAs to inhibit their function, leading to the dysregulation of their target mRNA transcripts that contribute to the EC regulation.

Conclusions

This review summarizes these networks of molecular mechanisms and their contribution to different aspects of endometrial carcinogenesis, leading to a better conceptualization of the molecular pathways that underlie the disease and helping establish novel diagnostic biomarkers and therapeutic intervention points to aid the curative intent of EC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Grillone K, Riillo C, Scionti F, Rocca R, Tradigo G, Guzzi PH, Alcaro S, Di Martino MT, Tagliaferri P, Tassone P (2020) Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter.” J Exp Clin Cancer Res 39:1–19

    Article  Google Scholar 

  2. Romano G, Veneziano D, Acunzo M, Croce CM (2017) Small non-coding RNA and cancer. Carcinogenesis 38:485–491

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wang W-T, Han C, Sun Y-M, Chen T-Q, Chen Y-Q (2019) Noncoding RNAs in cancer therapy resistance and targeted drug development. J Hematol Oncol 12:1–15

    Article  Google Scholar 

  4. Talhouk A, McAlpine JN (2016) New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care. Gynecol Oncol Res Pract 3:1–12

    Article  Google Scholar 

  5. Urick ME, Bell DW (2019) Clinical actionability of molecular targets in endometrial cancer. Nat Rev Cancer 19:510–521

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Remmerie M, Janssens V (2018) Targeted therapies in type II endometrial cancers: too little, but not too late. Int J Mol Sci 19:2380

    Article  PubMed Central  Google Scholar 

  7. Liu H, Wan J, Chu J (2019) Long non-coding RNAs and endometrial cancer. Biomed Pharmacother 119:109396

    Article  CAS  PubMed  Google Scholar 

  8. Vallone C, Rigon G, Gulia C, Baffa A, Votino R, Morosetti G, Zaami S, Briganti V, Catania F, Gaffi M (2018) Non-coding RNAs and endometrial cancer. Genes 9:187

    Article  PubMed Central  Google Scholar 

  9. La Ferlita A, Battaglia R, Andronico F, Caruso S, Cianci A, Purrello M, Di Pietro C (2018) Non-coding RNAs in endometrial physiopathology. Int J Mol Sci 19:2120

    Article  PubMed Central  Google Scholar 

  10. Piergentili R, Zaami S, Cavaliere AF, Signore F, Scambia G, Mattei A, Marinelli E, Gulia C, Perelli F (2021) Non-Coding RNAs as prognostic markers for endometrial cancer. Int J Mol Sci 22:3151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Takenaka K, Chen BJ, Modesitt SC, Byrne FL, Hoehn KL, Janitz M (2016) The emerging role of long non-coding RNAs in endometrial cancer. Cancer Genet 209:445–455

    Article  CAS  PubMed  Google Scholar 

  12. Chu C-Y, Rana TM (2007) Small RNAs: regulators and guardians of the genome. J Cell Physiol 213:412–419

    Article  CAS  PubMed  Google Scholar 

  13. Alberti C, Cochella L (2017) A framework for understanding the roles of miRNAs in animal development. Development 144:2548–2559

    Article  CAS  PubMed  Google Scholar 

  14. Peng Y, Croce CM (2016) The role of MicroRNAs in human cancer. Signal Transduct Target Ther 1:1–9

    Article  Google Scholar 

  15. Wang KC, Chang HY (2011) Molecular mechanisms of long noncoding RNAs. Mol Cell 43:904–914

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. López-Urrutia E, Bustamante Montes LP, Ladrón de Guevara Cervantes D, Pérez-Plasencia C, Campos-Parra AD (2019) Crosstalk between long non-coding RNAs, micro-RNAs and mRNAs: deciphering molecular mechanisms of master regulators in cancer. Front Oncol 9:669

    Article  PubMed  PubMed Central  Google Scholar 

  17. Ma L, Bajic VB, Zhang Z (2013) On the classification of long non-coding RNAs. RNA Biol 10:924–933

    Article  CAS  PubMed Central  Google Scholar 

  18. Yang C, Yang L, Zhou M, Xie H, Zhang C, Wang MD, Zhu H (2018) LncADeep: an ab initio lncRNA identification and functional annotation tool based on deep learning. Bioinformatics 34:3825–3834

    Article  CAS  PubMed  Google Scholar 

  19. Papait R, Kunderfranco P, Stirparo GG, Latronico MV, Condorelli G (2013) Long noncoding RNA: a new player of heart failure? J Cardiovasc Transl Res 6:876–883

    Article  PubMed  PubMed Central  Google Scholar 

  20. Pandey RR, Mondal T, Mohammad F, Enroth S, Redrup L, Komorowski J, Nagano T, Mancini-DiNardo D, Kanduri C (2008) Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell 32:232–246

    Article  CAS  PubMed  Google Scholar 

  21. Mohammad F, Mondal T, Kanduri C (2009) Epigenetics of imprinted long non-coding RNAs. Epigenetics 4:277–286

    Article  CAS  PubMed  Google Scholar 

  22. Wang T-H, Lin Y-S, Chen Y, Yeh C-T, Huang Y, Hsieh T-H, Shieh T-M, Hsueh C, Chen T-C (2015) Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. Oncotarget 6:23342

    Article  PubMed  PubMed Central  Google Scholar 

  23. Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P (2011) Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 43:621–629

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Fan J, Xing Y, Wen X, Jia R, Ni H, He J, Ding X, Pan H, Qian G, Ge S (2015) Long non-coding RNA ROR decoys gene-specific histone methylation to promote tumorigenesis. Genome Biol 16:1–17

    Google Scholar 

  25. Zhang W, Liu Y, Fu Y, Han W, Xu H, Wen L, Deng Y, Liu K (2020) Long non-coding RNA LINC00160 functions as a decoy of microRNA-132 to mediate autophagy and drug resistance in hepatocellular carcinoma via inhibition of PIK3R3. Cancer Lett 478:22–33

    Article  CAS  PubMed  Google Scholar 

  26. Balas MM, Johnson AM (2018) Exploring the mechanisms behind long noncoding RNAs and cancer. Non-Coding RNA Res 3:108–117

    Article  CAS  Google Scholar 

  27. Wu Y, Zhang LI, Zhang L, Wang Y, Li H, Ren X, Wei F, Yu W, Liu T, Wang X (2015) Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol 46:2586–2594

    Article  CAS  PubMed  Google Scholar 

  28. Dai Q, Zhang T, Pan J, Li C (2020) LncRNA UCA1 promotes cisplatin resistance in gastric cancer via recruiting EZH2 and activating PI3K/AKT pathway. J Cancer 11:3882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Jin L, Pan Y-L, Zhang J, Cao P-G (2021) LncRNA HOTAIR recruits SNAIL to inhibit the transcription of HNF4α and promote the viability, migration, invasion and EMT of colorectal cancer. Transl Oncol 14:101036

    Article  PubMed  PubMed Central  Google Scholar 

  30. Zappulla DC, Cech TR (2004) Yeast telomerase RNA: a flexible scaffold for protein subunits. Proc Natl Acad Sci 101:10024–10029

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Zhang C, Ge S, Gong W, Xu J, Guo Z, Liu Z, Gao X, Wei X, Ge S (2020) LncRNA ANRIL acts as a modular scaffold of WDR5 and HDAC3 complexes and promotes alteration of the vascular smooth muscle cell phenotype. Cell Death Dis 11:1–13

    Article  PubMed  PubMed Central  Google Scholar 

  32. Ma M, Zhang Y, Weng M, Hu Y, Xuan Y, Hu Y, Lv K (2018) lncRNA GCAWKR promotes gastric cancer development by scaffolding the chromatin modification factors WDR5 and KAT2A. Mol Ther 26:2658–2668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Xiao J, Lin L, Luo D, Shi L, Chen W, Fan H, Li Z, Ma X, Ni P, Yang L (2020) Long noncoding RNA TRPM2-AS acts as a microRNA sponge of miR-612 to promote gastric cancer progression and radioresistance. Oncogenesis 9:1–15

    Article  Google Scholar 

  34. Zhu S, Chen C-Y, Hao Y (2021) LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146. J Mol Histol 52:479–490

    Article  CAS  PubMed  Google Scholar 

  35. Wu F, Sui Y, Wang Y, Xu T, Fan L, Zhu H (2020) Long noncoding RNA SNHG7, a molecular sponge for microRNA-485, promotes the aggressive behavior of cervical cancer by regulating PAK4. OncoTargets Ther 13:685

    Article  CAS  Google Scholar 

  36. Wang Y, Pang W-J, Wei N, Xiong Y, Wu W-J, Zhao C-Z, Shen Q-W, Yang G-S (2014) Identification, stability and expression of Sirt1 antisense long non-coding RNA. Gene 539:117–124

    Article  CAS  PubMed  Google Scholar 

  37. Kimura T, Jiang S, Nishizawa M, Yoshigai E, Hashimoto I, Nishikawa M, Okumura T, Yamada H (2013) Stabilization of human interferon-α1 mRNA by its antisense RNA. Cell Mol Life Sci 70:1451–1467

    Article  CAS  PubMed  Google Scholar 

  38. Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W (2012) The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r. Nat Cell Biol 14:659–665

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Lu L, Luo F, Liu Y, Liu X, Shi L, Lu X, Liu Q (2015) Posttranscriptional silencing of the lncRNA MALAT1 by miR-217 inhibits the epithelial–mesenchymal transition via enhancer of zeste homolog 2 in the malignant transformation of HBE cells induced by cigarette smoke extract. Toxicol Appl Pharmacol 289:276–285

    Article  CAS  PubMed  Google Scholar 

  40. Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V, Chang I, Tanaka Y, Enokida H, Nakagawa M (2014) Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem 289:12550–12565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Yu Y, Nangia-Makker P, Farhana L, Majumdar AP (2017) A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells. Mol Cancer 16:1–11

    Article  Google Scholar 

  42. Mao Y, Liu R, Zhou H, Yin S, Zhao Q, Ding X, Wang H (2017) Transcriptome analysis of miRNA–lncRNA–mRNA interactions in the malignant transformation process of gastric cancer initiation. Cancer Gene Ther 24:267–275

    Article  CAS  PubMed  Google Scholar 

  43. Yeh I, Liu K-T, Shen J-H, Wu Y-H, Liu Y-H, Yen M-C, Kuo P-L (2020) Identification of the potential prognostic markers from the miRNA-lncRNA-mRNA interactions for metastatic renal cancer via next-generation sequencing and bioinformatics. Diagnostics 10:228

    Article  CAS  PubMed Central  Google Scholar 

  44. Xiao B, Zhang W, Chen L, Hang J, Wang L, Zhang R, Liao Y, Chen J, Ma Q, Sun Z (2018) Analysis of the miRNA–mRNA–lncRNA network in human estrogen receptor-positive and estrogen receptor-negative breast cancer based on TCGA data. Gene 658:28–35

    Article  CAS  PubMed  Google Scholar 

  45. Wang Y, Huang T, Sun X, Wang Y (2019) Identification of a potential prognostic lncRNA-miRNA-mRNA signature in endometrial cancer based on the competing endogenous RNA network. J Cell Biochem 120:18845–18853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Zhang X, Hamblin MH, Yin K-J (2017) The long noncoding RNA Malat1: its physiological and pathophysiological functions. RNA Biol 14:1705–1714

    Article  PubMed  PubMed Central  Google Scholar 

  47. Zhao Z, Chen C, Liu Y, Wu C (2014) 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochem Biophys Res Commun 445:388–393

    Article  CAS  PubMed  Google Scholar 

  48. Jiang Y, Li Y, Fang S, Jiang B, Qin C, Xie P, Zhou G, Li G (2014) The role of MALAT1 correlates with HPV in cervical cancer. Oncol Lett 7:2135–2141

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Zhao Y, Yang Y, Trovik J, Sun K, Zhou L, Jiang P, Lau T-S, Hoivik EA, Salvesen HB, Sun H (2014) A novel wnt regulatory axis in endometrioid endometrial cancer. Cancer Res 74:5103–5117

    Article  CAS  PubMed  Google Scholar 

  50. Zou A, Liu R, Wu X (2016) Long non-coding RNA MALAT1 is up-regulated in ovarian cancer tissue and promotes SK-OV-3 cell proliferation and invasion. Neoplasma 63:865–872

    Article  CAS  PubMed  Google Scholar 

  51. Zheng H-T, Shi D-B, Wang Y-W, Li X-X, Xu Y, Tripathi P, Gu W-L, Cai G-X, Cai S-J (2014) High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int J Clin Exp Pathol 7:3174

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Li Z-X, Zhu Q-N, Zhang H-B, Hu Y, Wang G, Zhu Y-S (2018) MALAT1: a potential biomarker in cancer. Cancer Manag Res 10:6757–6768. https://doi.org/10.2147/CMAR.S169406

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Li Q, Zhang C, Chen R, Xiong H, Qiu F, Liu S, Zhang M, Wang F, Wang Y, Zhou X (2016) Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma. Cancer Lett 383:28–40

    Article  CAS  PubMed  Google Scholar 

  54. Du Y, Zhang Z, Xiong W, Li N, Liu H, He H, Li Q, Liu Y, Zhang L (2019) Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function. Reproduction 157:179–188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Li Y-H, Hu Y-Q, Wang S-C, Li Y, Chen D-M (2020) LncRNA SNHG5: a new budding star in human cancers. Gene 749:144724

    Article  CAS  PubMed  Google Scholar 

  56. Damas ND, Marcatti M, Côme C, Christensen LL, Nielsen MM, Baumgartner R, Gylling HM, Maglieri G, Rundsten CF, Seemann SE (2016) SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization. Nat Commun 7:1–14

    Article  Google Scholar 

  57. Zhao L, Han T, Li Y, Sun J, Zhang S, Liu Y, Shan B, Zheng D, Shi J (2017) The lncRNA SNHG5/miR-32 axis regulates gastric cancer cell proliferation and migration by targeting KLF4, FASEB. J Off Publ Fed Am Soc Exp Biol 31:893–903. https://doi.org/10.1096/fj.201600994R

    Article  CAS  Google Scholar 

  58. Lin H, Shen L, Lin Q, Dong C, Maswela B, Illahi GS, Wu X (2020) SNHG5 enhances Paclitaxel sensitivity of ovarian cancer cells through sponging miR-23a. Biomed Pharmacother Biomedecine Pharmacother 123:109711. https://doi.org/10.1016/j.biopha.2019.109711

    Article  CAS  Google Scholar 

  59. Zhang L, Wu X, Li Y, Teng X, Zou L, Yu B (2021) LncRNA SNHG5 promotes cervical cancer progression by regulating the miR-132/SOX4 pathway. Autoimmunity 54:88–96. https://doi.org/10.1080/08916934.2020.1864731

    Article  CAS  PubMed  Google Scholar 

  60. Gong J, Cui Z, Li L, Ma Q, Wang Q, Gao Y, Sun H (2015) MicroRNA-25 promotes gastric cancer proliferation, invasion, and migration by directly targeting F-box and WD-40 Domain Protein 7, FBXW7. Tumor Biol 36:7831–7840

    Article  CAS  Google Scholar 

  61. Zoni E, van der Horst G, van de Merbel AF, Chen L, Rane JK, Pelger RC, Collins AT, Visakorpi T, Snaar-Jagalska BE, Maitland NJ (2015) miR-25 modulates invasiveness and dissemination of human prostate cancer cells via regulation of αv-and α6-integrin expression. Cancer Res 75:2326–2336

    Article  CAS  PubMed  Google Scholar 

  62. Li D, Zhang T, Lai J, Zhang J, Wang T, Ling Y, He S, Hu Z (2019) MicroRNA-25/ATXN3 interaction regulates human colon cancer cell growth and migration. Mol Med Rep 19:4213–4221

    PubMed  PubMed Central  Google Scholar 

  63. Feng S, Pan W, Jin Y, Zheng J (2014) MiR-25 promotes ovarian cancer proliferation and motility by targeting LATS2. Tumor Biol 35:12339–12344

    Article  CAS  Google Scholar 

  64. Chen H, Pan H, Qian Y, Zhou W, Liu X (2018) MiR-25-3p promotes the proliferation of triple negative breast cancer by targeting BTG2. Mol Cancer 17:1–11

    Article  Google Scholar 

  65. Li S, Shan Y, Li X, Zhang C, Wei S, Dai S, Zhao R, Zhao X, Zhao L, Shan B (2019) lncRNA SNHG5 modulates endometrial cancer progression via the miR-25–3p/BTG2 axis. J Oncol. https://doi.org/10.1155/2019/7024675

    Article  PubMed  PubMed Central  Google Scholar 

  66. Shen L, Wu Y, Li A, Li L, Shen L, Jiang Q, Li Q, Wu Z, Yu L, Zhang X (2020) LncRNA TTN-AS1 promotes endometrial cancer by sponging miR-376a-3p. Oncol Rep 44:1343–1354

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Chen P, Wang R, Yue Q, Hao M (2018) Long non-coding RNA TTN-AS1 promotes cell growth and metastasis in cervical cancer via miR-573/E2F3. Biochem Biophys Res Commun 503:2956–2962

    Article  CAS  PubMed  Google Scholar 

  68. Wang Y, Jiang F, Xiong Y, Cheng X, Qiu Z, Song R (2020) LncRNA TTN-AS1 sponges miR-376a-3p to promote colorectal cancer progression via upregulating KLF15. Life Sci 244:116936

    Article  CAS  PubMed  Google Scholar 

  69. Fu D, Lu C, Qu X, Li P, Chen K, Shan L, Zhu X (2019) LncRNA TTN-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. Aging 11:8374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Zhang C, Liang Y, Ma M-H, Wu K-Z, Zhang C-D, Dai D-Q (2018) Downregulation of microRNA-376a in gastric cancer and association with poor prognosis. Cell Physiol Biochem 51:2010–2018

    Article  CAS  PubMed  Google Scholar 

  71. Fellenberg J, Lehner B, Saehr H, Schenker A, Kunz P (2019) Tumor suppressor function of miR-127–3p and miR-376a-3p in osteosarcoma cells. Cancers. https://doi.org/10.3390/cancers11122019

    Article  PubMed  PubMed Central  Google Scholar 

  72. Chen X, Li LQ, Qiu X, Wu H (2019) Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis. Neoplasma 66:386–396

    Article  CAS  PubMed  Google Scholar 

  73. Chen R, Zhang X, Wang C (2020) LncRNA HOXB-AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1. J Cell Biochem 121:4043–4051

    Article  CAS  PubMed  Google Scholar 

  74. He Y, Yu D, Zhu L, Zhong S, Zhao J, Tang J (2018) miR-149 in human cancer: a systemic review. J Cancer 9:375

    Article  PubMed  PubMed Central  Google Scholar 

  75. Liu D, Qiu M, Jiang L, Liu K (2020) Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b. Technol Cancer Res Treat 19:1533033820967462

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Dong P, Xiong Y, Yue J, Hanley SJ, Kobayashi N, Todo Y, Watari H (2018) Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors. Front Genet 9:471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Liu Y, Wang Y, Fu X, Lu Z (2018) Long non-coding RNA NEAT 1 promoted ovarian cancer cells’ metastasis through regulation of miR-382-3p/ROCK 1 axial. Cancer Sci 109:2188–2198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Luo Y, Chen J-J, Lv Q, Qin J, Huang Y-Z, Yu M-H, Zhong M (2019) Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/β-catenin signaling pathway. Cancer Lett 440:11–22

    Article  PubMed  Google Scholar 

  79. Jiang Y, Jin S, Tan S, Xue Y, Cao X (2020) Long noncoding RNA NEAT1 regulates radio-sensitivity via microRNA-27b-3p in gastric cancer. Cancer Cell Int 20:1–12

    Article  CAS  Google Scholar 

  80. Zhen L, Yun-Hui L, Hong-Yu D, Jun M, Yi-Long Y (2016) Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p/c-Met axis. Tumor Biol 37:673–683

    Article  Google Scholar 

  81. Jiang X, Zhou Y, Sun A-J, Xue J-L (2018) NEAT1 contributes to breast cancer progression through modulating miR-448 and ZEB1. J Cell Physiol 233:8558–8566

    Article  CAS  PubMed  Google Scholar 

  82. Xu D, Dong P, Xiong Y, Yue J, Ihira K, Konno Y, Kobayashi N, Todo Y, Watari H (2019) MicroRNA-361: A multifaceted player regulating tumor aggressiveness and tumor microenvironment formation. Cancers 11:1130

    Article  CAS  PubMed Central  Google Scholar 

  83. Dong P, Xiong Y, Yue J, Xu D, Ihira K, Konno Y, Kobayashi N, Todo Y, Watari H (2019) Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment-related genes. J Exp Clin Cancer Res 38:1–15

    Article  CAS  Google Scholar 

  84. Kooshkaki O, Rezaei Z, Rahmati M, Vahedi P, Derakhshani A, Brunetti O, Baghbanzadeh A, Mansoori B, Silvestris N, Baradaran B (2020) MiR-144: A new possible therapeutic target and diagnostic/prognostic tool in cancers. Int J Mol Sci 21:2578

    Article  CAS  PubMed Central  Google Scholar 

  85. Wang W, Ge L, Xu X-J, Yang T, Yuan Y, Ma X-L, Zhang X-H (2019) LncRNA NEAT1 promotes endometrial cancer cell proliferation, migration and invasion by regulating the miR-144-3p/EZH2 axis. Radiol Oncol 53:434–442

    Article  PubMed  PubMed Central  Google Scholar 

  86. Penna E, Orso F, Taverna D (2015) miR-214 as a key hub that controls cancer networks: small player, multiple functions. J Invest Dermatol 135:960–969

    Article  CAS  PubMed  Google Scholar 

  87. Wang J, Zhao X, Guo Z, Ma X, Song Y, Guo Y (2017) Regulation of NEAT1/miR-214-3p on the growth, migration and invasion of endometrial carcinoma cells. Arch Gynecol Obstet 295:1469–1475

    Article  CAS  PubMed  Google Scholar 

  88. Mozdarani H, Ezzatizadeh V, Rahbar Parvaneh R (2020) The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment. J Transl Med 18:1–15

    Article  Google Scholar 

  89. Cantile M, Di Bonito M, Tracey De Bellis M, Botti G (2021) Functional interaction among lncRNA HOTAIR and microRNAs in cancer and other human diseases. Cancers 13:570

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Zhang P, Tang WM, Zhang H, Li YQ, Peng Y, Wang J, Liu GN, Huang XT, Zhao JJ, Li G (2017) MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. Br J Cancer 117:525–534

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Darvishi N, Rahimi K, Mansouri K, Fathi F, Menbari M-N, Mohammadi G, Abdi M (2020) MiR-646 prevents proliferation and progression of human breast cancer cell lines by suppressing HDAC2 expression. Mol Cell Probes 53:101649

    Article  CAS  PubMed  Google Scholar 

  92. Zhou Y, Wang C, Mao L, Wang Y, Xia L, Zhao W, Shen J, Chen J (2018) Long noncoding RNA HOTAIR mediates the estrogen-induced metastasis of endometrial cancer cells via the miR-646/NPM1 axis. Am J Physiol Cell Physiol 314:C690–C701

    Article  CAS  PubMed  Google Scholar 

  93. Zhang C, Wu W, Ye X, Ma R, Luo J, Zhu H, Chang X (2019) Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis. Eur J Obstet Gynecol Reprod Biol 236:177–182

    Article  CAS  PubMed  Google Scholar 

  94. Yokoi A (2018) Integrated extracellular microRNA profiling for ovarian cancer screening. Nat Commun 9:4319

    Article  PubMed  PubMed Central  Google Scholar 

  95. Shi Y, Zha J, Zuo M, Yan Q, Song H (2020) Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer. J Cell Biochem 121:2655–2663

    Article  CAS  PubMed  Google Scholar 

  96. Liu Y, He A, Liu B, Huang Z, Mei H (2019) Potential role of lncRNA H19 as a cancer biomarker in human cancers detection and diagnosis: a pooled analysis based on 1585 subjects. BioMed Res Int. https://doi.org/10.1155/2019/9056458

    Article  PubMed  PubMed Central  Google Scholar 

  97. Zhou X, Ye F, Yin C, Zhuang Y, Yue G, Zhang G (2015) The interaction between MiR-141 and lncRNA-H19 in regulating cell proliferation and migration in gastric cancer. Cell Physiol Biochem 36:1440–1452

    Article  PubMed  Google Scholar 

  98. Zhong M-E, Chen Y, Zhang G, Xu L, Ge W, Wu B (2019) LncRNA H19 regulates PI3K–Akt signal pathway by functioning as a ceRNA and predicts poor prognosis in colorectal cancer: integrative analysis of dysregulated ncRNA-associated ceRNA network. Cancer Cell Int 19:1–13

    Article  Google Scholar 

  99. Liu M, Chen Y, Huang B, Mao S, Cai K, Wang L, Yao X (2018) Tumor-suppressing effects of microRNA-612 in bladder cancer cells by targeting malic enzyme 1 expression. Int J Oncol 52:1923–1933

    CAS  PubMed  PubMed Central  Google Scholar 

  100. Zhu Y, Zhang H, Wang Q, Chen M, Liu L (2018) Overexpression of microRNA-612 restrains the growth, invasion, and tumorigenesis of melanoma cells by targeting espin. Mol Cells 41:119

    CAS  PubMed  PubMed Central  Google Scholar 

  101. Liu Y, Lu L-L, Wen D, Liu D-L, Dong L-L, Gao D-M, Bian X-Y, Zhou J, Fan J, Wu W-Z (2020) MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming. J Hematol Oncol 13:12

    Article  PubMed  PubMed Central  Google Scholar 

  102. Yu H, Xu Y, Zhang D, Liu G (2018) Long noncoding RNA LUCAT1 promotes malignancy of ovarian cancer through regulation of miR-612/HOXA13 pathway. Biochem Biophys Res Commun 503:2095–2100

    Article  CAS  PubMed  Google Scholar 

  103. Zhang L, Wang DL, Yu P (2018) LncRNA H19 regulates the expression of its target gene HOXA10 in endometrial carcinoma through competing with miR-612. Eur Rev Med Pharmacol Sci 22:4820–4827

    CAS  PubMed  Google Scholar 

  104. Yan L, Zhou J, Gao Y, Ghazal S, Lu L, Bellone S, Yang Y, Liu N, Zhao X, Santin AD, Taylor H, Huang Y (2015) Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation. Oncogene 34:3076–3084. https://doi.org/10.1038/onc.2014.236

    Article  CAS  PubMed  Google Scholar 

  105. Li S, Zheng K, Pei Y, Wang W, Zhang X (2019) Long noncoding RNA NR2F1-AS1 enhances the malignant properties of osteosarcoma by increasing forkhead box A1 expression via sponging of microRNA-483-3p. Aging 11:11609

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  106. Guo F, Fu Q, Wang Y, Sui G (2019) Long non-coding RNA NR2F1-AS1 promoted proliferation and migration yet suppressed apoptosis of thyroid cancer cells through regulating miRNA-338-3p/CCND1 axis. J Cell Mol Med 23:5907–5919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Huang H, Chen J, Ding C-M, Jin X, Jia Z-M, Peng J (2018) Lnc RNA NR 2F1-AS 1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC 1 via miR-363. J Cell Mol Med 22:3238–3245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Sanchez Calle A, Yamamoto T, Kawamura Y, Hironaka-Mitsuhashi A, Ono M, Tsuda H, Shimomura A, Tamura K, Takeshita F, Ochiya T (2020) Long non-coding NR2F1-AS1 is associated with tumor recurrence in estrogen receptor-positive breast cancers. Mol Oncol 14:2271–2287

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. He F, Fang L, Yin Q (2019) miR-363 acts as a tumor suppressor in osteosarcoma cells by inhibiting PDZD2. Oncol Rep 41:2729–2738

    CAS  PubMed  PubMed Central  Google Scholar 

  110. Ye J, Zhang W, Liu S, Liu Y, Liu K (2017) miR-363 inhibits the growth, migration and invasion of hepatocellular carcinoma cells by regulating E2F3. Oncol Rep 38:3677–3684

    CAS  PubMed  Google Scholar 

  111. Lin Y, Xu T, Zhou S, Cui M (2017) MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1. Oncotarget. 8:101649

    Article  PubMed  PubMed Central  Google Scholar 

  112. Wang L, Zhao S, Mingxin YU (2019) LncRNA NR2F1-AS1 is involved in the progression of endometrial cancer by sponging miR-363 to target SOX4. Pharm Int J Pharm Sci 74:295–300

    CAS  Google Scholar 

  113. Yu Y, Hann SS (2019) Novel tumor suppressor lncRNA growth arrest-specific 5 (GAS5) in human cancer. OncoTargets Ther 12:8421

    Article  CAS  Google Scholar 

  114. Geng L, Sun B, Gao B, Wang Z, Quan C, Wei F, Fang X-D (2014) MicroRNA-103 promotes colorectal cancer by targeting tumor suppressor DICER and PTEN. Int J Mol Sci 15:8458–8472

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Yu D, Zhou H, Xun Q, Xu X, Ling J, Hu Y (2012) microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3. Oncol Lett 3:1221–1226

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Zheng J, Liu Y, Qiao Y, Zhang L, Lu S (2017) miR-103 promotes proliferation and metastasis by targeting KLF4 in gastric cancer. Int J Mol Sci 18:910

    Article  PubMed Central  Google Scholar 

  117. Guo C, Song W, Sun P, Jin L, Dai H (2015) LncRNA-GAS5 induces PTEN expression through inhibiting miR-103 in endometrial cancer cells. J Biomed Sci 22:1–9

    Article  CAS  Google Scholar 

  118. Zhang L, Li C, Su X (2020) Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers. J Exp Clin Cancer Res 39:1–12

    Article  CAS  Google Scholar 

  119. Jin Y, Chen Q, Xu K, Ren H, Bao X, Ma Y, Wei Y, Bing Ma H (2016) Involvement of microRNA-141–3p in 5-fluorouracil and oxaliplatin chemo-resistance in esophageal cancer cells via regulation of PTEN. Mol Cell Biochem 422:161–170

    Article  CAS  PubMed  Google Scholar 

  120. Li J, Li J, Wang H, Li X, Wen B, Wang Y (2017) MiR-141-3p promotes prostate cancer cell proliferation through inhibiting kruppel-like factor-9 expression. Biochem Biophys Res Commun 482:1381–1386

    Article  CAS  PubMed  Google Scholar 

  121. Liang Z, Li X, Liu S, Li C, Wang X, Xing J (2019) MiR-141–3p inhibits cell proliferation, migration and invasion by targeting TRAF5 in colorectal cancer. Biochem Biophys Res Commun 514:699–705

    Article  CAS  PubMed  Google Scholar 

  122. Wang M, Hu M, Li Z, Qian D, Wang B, Liu DX (2017) miR-141-3p functions as a tumor suppressor modulating activating transcription factor 5 in glioma. Biochem Biophys Res Commun 490:1260–1267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  123. Cui Z, An X, Li J, Liu Q, Liu W (2018) LncRNA MIR22HG negatively regulates miR-141-3p to enhance DAPK1 expression and inhibits endometrial carcinoma cells proliferation. Biomed Pharmacother 104:223–228

    Article  CAS  PubMed  Google Scholar 

  124. Zhang P, Li S, Chen Z, Lu Y, Zhang H (2020) LncRNA SNHG8 promotes proliferation and invasion of gastric cancer cells by targeting the miR-491/PDGFRA axis. Hum Cell 33:123–130

    Article  PubMed  Google Scholar 

  125. Dong J, Teng F, Guo W, Yang J, Ding G, Fu Z (2018) lncRNA SNHG8 promotes the tumorigenesis and metastasis by sponging miR-149-5p and predicts tumor recurrence in hepatocellular carcinoma. Cell Physiol Biochem 51:2262–2274

    Article  CAS  PubMed  Google Scholar 

  126. Zhen Y, Ye Y, Wang H, Xia Z, Wang B, Yi W, Deng X (2019) Knockdown of SNHG8 repressed the growth, migration, and invasion of colorectal cancer cells by directly sponging with miR-663. Biomed Pharmacother. 116:109000

    Article  CAS  PubMed  Google Scholar 

  127. Xu X, Xie Q, Xie M, Zeng Y, Liu Q (2021) LncRNA SNHG8 Serves as an Oncogene in Breast Cancer Through miR-634/ZBTB20 Axis. Cancer Manag Res 13:3017

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Liu X, Li J, Qin F, Dai S (2016) miR-152 as a tumor suppressor microRNA: Target recognition and regulation in cancer. Oncol Lett 11:3911–3916

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  129. Yang CH, Zhang XY, Zhou LN, Wan Y, Song LL, Gu WL, Liu R, Ma YN, Meng HR, Tian YL (2018) LncRNA SNHG8 participates in the development of endometrial carcinoma through regulating c-MET expression by miR-152. Eur Rev Med Pharmacol Sci 22:1629–1637

    PubMed  Google Scholar 

  130. Xin W, Gao X, Zhao S, Zhao P, Yu H, Wu Q, Hua K (2020) LncRNA RP11–395G23. 3 suppresses the endometrial cancer progression via regulating microRNA-205–5p/PTEN axis. Am. J. Transl. Res. 12:4422

    CAS  PubMed  PubMed Central  Google Scholar 

  131. Xin W, Zhao S, Han X, Zhao P, Yu H, Gao X, Li P, Wu Q, Ding J, Hua K (2020) lncRNA LA16c-313D11. 11 modulates the development of endometrial cancer by binding to and inhibiting microRNA-205–5p function and indirectly increasing PTEN activity. Int J Oncol 57:355–363

    PubMed  Google Scholar 

Download references

Acknowledgements

We apologize to many scientists whose research studies were not included in this review due to the page/word limit.

Funding

PSS thank Faculty seed research grant of National Institute of Technology, Calicut and Department of Biotechnology (BT/PR16307/MED/30/1729/2016) Govt of India and Department of Science and Technology-Science engineering research board (YSS/2014/000020), for the support.

Author information

Authors and Affiliations

  1. Department of Biosciences, Mangalore University, Mangalagangothri, Mangalore, 574 199, Karnataka, India

    Abhishek Shetty

  2. Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, 671316, Kerala, India

    Thejaswini Venkatesh

  3. Department of Cell and Molecular Biology, School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Shama Prasada Kabbekodu

  4. Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, 770-8503, Japan

    Rie Tsutsumi

  5. School of Biotechnology, National Institute of Technology, Calicut, 673601, Kerala, India

    Padmanaban S. Suresh

Authors
  1. Abhishek Shetty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thejaswini Venkatesh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shama Prasada Kabbekodu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rie Tsutsumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Padmanaban S. Suresh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Padmanaban S. Suresh.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethics approval

Not applicable (review article); Consent to participate, publication, and availability of data and materials: not applicable as it is review article. Conceptualization; supervision; funding acquisition, Writing Original manuscript: PSS; Writing Original manuscript: AS; Reviewing and editing: TV, SPK, RT and PSS.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shetty, A., Venkatesh, T., Kabbekodu, S.P. et al. LncRNA–miRNA–mRNA regulatory axes in endometrial cancer: a comprehensive overview. Arch Gynecol Obstet 306, 1431–1447 (2022). https://doi.org/10.1007/s00404-022-06423-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-022-06423-5

Keywords

Search

Navigation