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Effects of oral intake of cetirizine HCl and desloratadine molecules on the middle ear mucosa: an experimental animal study

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Abstract

We have planned to demonstrate histopathologic effects of mid- or long-term oral use of desloratadine and cetirizine HCl molecules on middle ear mucosa of rats. Thirty-six rats were randomized equally into six groups. Desloratadine groups received once daily doses of 1 mg/ml desloratadine for 30 (D30 Group) or 60 (D60 Group) days. The Cetirizine study groups were given once daily doses of 1 mg/ml cetirizine for 30 (S30 Group) or 60 (S60 Group) days. Control groups were given 2 cc physiologic saline using orogastric gavage method through a 12 G gavage catheter for 30 (K30 Group) or 60 (K60) days. At the end of 30 days, D30, S30 and K30 Groups were sacrificed. Tissue samples harvested from groups were evaluated between 1 and 4 Grades for histological characteristics of middle ear canal, eardrum, middle ear epithelium and connective tissue, edema, vascular congestion and inflammatory cells. In the control group no pathological finding was encountered in rats sacrificed on 30 and 60 days. No statistical difference was observed when groups were compared on external ear epithelial tissue, external ear sebaceous gland, middle ear inflammation, and middle ear capillary dilatation both on 30 and 60 days. Tympanic membrane collagen was more evident in D30 and D60 groups when compared with C30 and C60 groups. Comparison of histopathological grading results between 30 and 60 days revealed no significant changes. In conclusion, oral intake of cetirizine and desloratadine preparations has effects of tympanic membrane collagen, degrees of edema and vascular congestion being more prominent with desloratadine molecule.

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Acknowledgments

The English in this document has been checked by a professional editor, native speaker of English.

Conflict of interest

The authors declare no competing interest. No financial support was received for this paper. Authors indicate that they do not have a financial relationship with the organization that sponsored the research.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Atatürk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey

    Murat Songu, Yilmaz Ozkul, Seyithan Kirtay, Secil Arslanoglu & Kazim Onal

  2. Department of Histology and Embriology, Celal Bayar University Medical Faculty, Manisa, Turkey

    Mahmut Ozkut & Sevinc Inan

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  1. Murat Songu
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  2. Yilmaz Ozkul
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  3. Seyithan Kirtay
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  5. Mahmut Ozkut
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  6. Sevinc Inan
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  7. Kazim Onal
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Correspondence to Murat Songu.

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Songu, M., Ozkul, Y., Kirtay, S. et al. Effects of oral intake of cetirizine HCl and desloratadine molecules on the middle ear mucosa: an experimental animal study. Eur Arch Otorhinolaryngol 271, 833–838 (2014). https://doi.org/10.1007/s00405-014-2928-3

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  • DOI: https://doi.org/10.1007/s00405-014-2928-3

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