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Recent approaches to psychological interventions for people at risk of psychosis

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Abstract

With the emerging global focus on early psychosis, indicated prevention in schizophrenia has increasingly become a focus of psychiatric research interests. It has been argued that CBT may have some advantages compared with antipsychotics regarding this issue. According to MEDLINE, EMBASE and Psycinfo two completed randomised controlled trials (RCTs; PACE, Melbourne, Australia; EDIE, Manchester, United Kingdom) and one ongoing RCT with only preliminary results published so far (FETZ, Cologne/Bonn, Germany) on indicated prevention in schizophrenia including manualised and standardised psychological treatment can be identified. The aims of the present paper are to present and discuss the three approaches with regard to (I) inclusion, exclusion and exit criteria, (II) characteristics of interventions and (III) evaluations. All interventions use intake, exclusion and exit criteria, which have been evaluated in prospective follow-along studies. The approaches are based on the general structure and principles of cognitive behavioural therapy which have been developed, applied and evaluated in a wide range of mental health problems. Despite several methodological limitations, the first evaluations indicate some effects with regard to three possible aims of early intervention: (1) improvement of present possible pre-psychotic symptoms, (2) prevention of social decline/stagnation and (3) prevention or delay of progression to psychosis. Even though the first results are promising, we conclude that several ethical issues have to be taken into consideration and further predictive and therapeutic research is needed to judge whether psychological intervention is a realistic option for the treatment of people at risk of psychosis.

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Authors and Affiliations

  1. Early Recognition and Intervention, Centre for mental crises (FETZ), Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany

    Andreas Bechdolf M. D., Verena Veith & Joachim Klosterkötter

  2. Personal Assessment and Crisis Evaluation (PACE) Clinic, ORYGEN Youth Health, Melbourne, Australia

    Lisa J. Phillips, Shona M. Francey, Steven Leicester & Patrick D. McGorry

  3. Early Detection and Intervention Evaluation (EDIE) Department of Psychology, University of Manchester, UK

    Anthony P. Morrison

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  1. Andreas Bechdolf M. D.
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  2. Lisa J. Phillips
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  3. Shona M. Francey
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  4. Steven Leicester
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  5. Anthony P. Morrison
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  6. Verena Veith
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  7. Joachim Klosterkötter
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  8. Patrick D. McGorry
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Correspondence to Andreas Bechdolf M. D..

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Bechdolf, A., Phillips, L.J., Francey, S.M. et al. Recent approaches to psychological interventions for people at risk of psychosis. Eur Arch Psychiatry Clin Neurosci 256, 159–173 (2006). https://doi.org/10.1007/s00406-006-0623-0

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