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Now a Nobel gas: oxygen

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Abstract

The recent bestowal of the Nobel Prize 2019 in Physiology or Medicine to Gregg L. Semenza, Sir Peter J. Ratcliffe, and William G. Kaelin Jr. celebrates a series of remarkable discoveries that span from the physiological research question on how oxygen deficiency (hypoxia) induces the red blood cell forming hormone erythropoietin (Epo) to the first clinical application of a novel family of Epo-inducing drugs to treat patients suffering from renal anemia. This review looks back at the most important findings made by the three Nobel laureates, highlights current research trends, and sheds an eye on future perspectives of hypoxia research, including emerging and potential clinical applications.

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Funding

RHW was supported by the National Centre of Competence in Research “Kidney.CH” and the Swiss National Science Foundation (310030_184813); and JS received funding from the German Research Foundation (387509280-SFB 1350 C5).

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Authors and Affiliations

  1. Institute of Physiology, University of Duisburg-Essen, 45122, Essen, Germany

    Joachim Fandrey

  2. Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nuremberg, 91054, Erlangen, Germany

    Johannes Schödel

  3. Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany

    Kai-Uwe Eckardt

  4. Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, 37073, Göttingen, Germany

    Dörthe M. Katschinski

  5. Institute of Physiology and National Center of Competence in Research “Kidney.CH”, University of Zürich, CH-8057, Zürich, Switzerland

    Roland H. Wenger

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Fandrey, J., Schödel, J., Eckardt, KU. et al. Now a Nobel gas: oxygen. Pflugers Arch - Eur J Physiol 471, 1343–1358 (2019). https://doi.org/10.1007/s00424-019-02334-8

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