Abstract
This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.
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21 February 2020
This erratum is meant to address the error in which the names of one of the authors of the manuscript, was incorrect. Author assumes full responsibility for this error.
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The authors would like to acknowledge all workshop participants for their case submissions and for grant permission for the use of images in this review and Dr. Feldman for kindly testing a subset of cases for STAT3-JAK2 fusion by FISH.
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All authors conceived and designed the review; all authors participated into the collection, discussion, and the final diagnostic workup of the submitted cases. SMM and MC wrote the first draft of the manuscript that was edited and reviewed by the others. All authors gave their final approval for publication.
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The original version of this article was revised: The names of one of the authors of the manuscript, was incorrect. Author assumes full responsibility for this error.
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Montes-Moreno, S., King, R.L., Oschlies, I. et al. Update on lymphoproliferative disorders of the gastrointestinal tract: disease spectrum from indolent lymphoproliferations to aggressive lymphomas. Virchows Arch 476, 667–681 (2020). https://doi.org/10.1007/s00428-019-02704-8
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DOI: https://doi.org/10.1007/s00428-019-02704-8